Office of Environmental Health Hazard Assessment

Air Toxicology and Epidemiology

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All Chronic Reference Exposure Levels (cRELs)
 

Substance
(CAS #)

Listed in CAPCOA

(1993)

Chronic
Inhalation REL
(µg/m3)

Hazard Index
Target(s)

Human Data

1 Acetaldehyde*
(75-07-0)

yes

9

Respiratory system

 

2

Acrolein
(107-02-8)

yes

0.06

Respiratory system; eyes  
3 Acrylonitrile
(107-13-1)

yes

5

Respiratory system  

4

Ammonia
(7664-41-7)

yes

200

Respiratory system

yes

5

Arsenic
(7440-38-2) & arsenic compounds

yes

0.03

Development; Cardiovascular system; Nervous system

 

6

Benzene
(71-43-2)

yes

60

Hematopoietic system; development; nervous system

yes

7

Beryllium
(7440-41-7)
and beryllium compounds

yes

0.007

Respiratory system; immune system

yes

8

Butadiene
(106-99-0)
  20 Reproductive system  

9

Cadmium
(7440-43-9) & cadmium compounds

yes

0.02

Kidney; respiratory system

yes

10

Carbon tetrachloride
(56-23-5)

yes

40

Alimentary system; development; nervous system  
11 Carbon disulfide
(75-15-0)
 

800

Nervous system; reproductive system

yes

12

Chlorinated dioxins
(1746-01-6) & dibenzofurans
(5120-73-19)

yes

0.00004

Alimentary system (liver); reproductive system; development; endocrine system; respiratory system; hematopoietic system

 

13

Chlorine
(7782-50-5)

yes

0.2

Respiratory system

 

14

Chlorine dioxide(10049-04-4)  

0.6

Respiratory system  

15

Chlorobenzene
(108-90-7)

yes

1000

Alimentary system; kidney; reproductive system  

16

Chloroform
(67-66-3)

yes

300

Alimentary system; kidney; development

 

17

Chloropicrin
(76-06-2)

yes

0.4 Respiratory system  

18

Chromium hexavalent: soluble except chromic trioxide

yes

0.2

Respiratory system  

19

Chromic trioxide (as chromic acid mist)

yes

0.002

Respiratory system

yes

20

Cresol mixtures (1319-77-3)

yes

600

Nervous system  

21

Dichlorobenzene (1,4-)
(106-46-7)

yes

800

Nervous system; respiratory system; alimentary system; kidney  

22

Dichloroethylene (1,1) (75-35-4)

yes

70

Alimentary system  

23

Diesel Exhaust*  

5

Respiratory system  

24

Diethanolamine
(111-42-2)
 

3

Cardiovascular system; nervous system  

25

Dimethylformamide (N,N-)
(68-12-2)
 

80

Alimentary system ; respiratory system

yes

26

Dioxane (1,4-)
(123-91-1)

yes

3,000

Alimentary system; kidney; cardiovascular system

 

27

Epichlorohydrin
(106-89-8)

yes

3

Respiratory system; eyes  

28

Epoxybutane (1,2-) (106-88-7)  

20

Respiratory system; cardiovascular system  

29

Ethylbenzene
(100-41-4)

 

2,000

Development; alimentary system (liver); kidney; endocrine system

 

30

Ethyl chloride
(75-00-3)

yes

30,000

Development; alimentary system

 

31

Ethylene dibromide
(106-93-4)

yes

0.8

Reproductive system

yes

32

Ethylene dichloride (107-06-2)

yes

400

Alimentary system (liver)  

33

Ethylene glycol
(107-21-1)

 

400

Respiratory system; kidney; development

yes

34

Ethylene glycol monoethyl ether (110-80-5)

yes

70

Reproductive system; hematopoietic system

 

35

Ethylene glycol monoethyl ether acetate
(111-15-9)

yes

300

Development

 

36

Ethylene glycol monomethyl ether
(109-86-4)

yes

60

Reproductive system

 

37

Ethylene glycol monomethyl ether acetate (110-49-6)

yes

90

Reproductive system

 

38

Ethylene oxide
(75-21-8)

yes

30

Nervous system  

39

Fluoride including Hydrogen Fluoride  

13 F

14 HF

Bone and teeth; respiratory system

yes

40

Formaldehyde
(50-00-0)

yes

3

Respiratory system; eyes

yes

41

Glutaraldehyde (111-30-8)

yes

0.08 Respiratory system  
42

Hexane (n-)
(110-54-3)

 

7000

Nervous system

 

43

Hydrazine
(302-01-2)

yes

0.2 Alimentary system; endocrine system  

44

Hydrogen chloride
(7647-01-0)

yes

9

Respiratory system

 
45

Hydrogen cyanide
(74-90-8)

yes

9

Nervous system; endocrine system; cardiovascular system

yes

46

Hydrogen sulfide
(7783-06-4)

yes

10

Respiratory system

 
47 Isophorone
(78-59-1)
  2000 Development; liver  

48

Isopropanol
(67-63-0)

 

7,000

Kidney; development

 
49 Maleic anhydride
(108-31-6)

yes

0.7 Respiratory system  
50

Manganese & manganese compounds

yes

0.2

Nervous system

yes

51

Mercury & mercury compounds (inorganic)

yes

0.09

Nervous system

yes

52

Methanol
(67-56-1)

yes

4,000

Development

 

53

Methyl bromide
(74-83-9)

yes

5

Respiratory system; nervous system; development

 

54

Methyl chloroform
(71-55-6)

yes

1,000

Nervous system

 
55 Methyl isocyanate
(624-83-9)
  1 Respiratory system; reproductive system  

56

Methyl t-butyl ether
(1634-04-4)

 

8,000

Kidney; eyes; alimentary system (liver)

 

57

Methylene chloride
(75-09-2)

yes

400

Cardiovascular system; nervous system

yes

58 Methylene dianiline (4,4'-) (101-77-9)

yes

20 Eyes; alimentary system (hepatotoxicity)  

59

Methylene Diphenyl Isocyanate (101-68-8)   0.7 Respiratory system  
60

Naphthalene
(91-20-3)

yes

9

Respiratory system

 

61

Nickel & compounds

(except nickel oxide)

yes

0.05

Respiratory system; hematopoietic system

 
62

 

Nickel oxide
(1313-99-1)

 

0.1

Respiratory system; hematopoietic system

 
63

Phenol
(108-95-2)

yes

200

Alimentary system; cardiovascular system; kidney; nervous system

 
64 Phosphine
(7803-51-2)

yes

0.8

Respiratory system; alimentary system; nervous system; kidney; hematopoietic system  

65

Phosphoric acid
(7664-38-2)

 

7

Respiratory system

 

66

Phthalic anhydride (85-44-9)

yes

20

Respiratory system

yes

67

Propylene
(115-07-1)

 

3,000

Respiratory system

 

68

Propylene glycol monomethyl ether
(107-98-2)

 

7,000

Alimentary system (liver)

 

69

Propylene oxide
(75-56-9)

yes

30

Respiratory system

 
70 Selenium and selenium compounds (other than hydrogen selenide)

yes

20 Alimentary system; cardiovascular system; nervous system

yes

71 Silica (crystalline, respirable)   3 Respiratory system

yes

72

Styrene
(100-42-5)

yes

900

Nervous system

yes

73 Sulfuric acid
(7664-93-9)
  1 Respiratory system  
74 Tetrachloroethylene*
(perchloroethylene)
(127-18-4)

yes

35 Kidney; alimentary system (liver)  
75

Toluene
(108-88-3)

yes

300

Nervous system; respiratory system; development

 

76

Toluene diisocyanates (2,4-&2,6-)

yes

0.07 Respiratory system

yes

77

Trichloroethylene
(79-01-6)

yes

600

Nervous system; eyes

yes

78 Triethylamine
(121-44-8)
  200 Eyes  
79 Vinyl acetate
(108-05-4)
  200 Respiratory system  

80

Xylenes
(m-, o-, p-)

yes

700

Nervous system; respiratory system

yes

*These peer-reviewed values were developed under the Toxic Air Contaminant (TAC) Program mandated by AB1807.

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