STATE OF CALIFORNIA
ENVIRONMENTAL PROTECTION AGENCY
OFFICE OF ENVIRONMENTAL HEALTH HAZARD ASSESSMENT
SAFE DRINKING WATER AND TOXIC ENFORCEMENT ACT OF 1986
CHEMICALS KNOWN TO THE STATE TO CAUSE
CANCER OR REPRODUCTIVE TOXICITY
June 28, 2002
The Safe Drinking Water and Toxic Enforcement Act of 1986 requires that the Governor revise and republish at least once per year the list of chemicals known to the State to cause cancer or reproductive toxicity. The identification number indicated in the following list is the Chemical Abstracts Service (CAS) Registry Number. No CAS number is given when several substances are presented as a single listing. The date refers to the initial appearance of the chemical on the list. For easy reference, chemicals which are shown underlined are newly added. Chemicals which are shown with a strikeout are chemicals recommended for removal from the list by the “state’s qualified experts.”
CHEMICALS KNOWN TO THE STATE TO CAUSE CANCER
|
Chemical |
CAS Number |
Date |
|
A-alpha-C (2-Amino-9H-pyrido[2,3-b]indole) |
26148685 |
January 1, 1990 |
|
Acetaldehyde |
75070 |
April 1, 1988 |
|
Acetamide |
60355 |
January 1, 1990 |
|
Acetochlor |
34256821 |
January 1, 1989 |
|
2-Acetylaminofluorene |
53963 |
July 1, 1987 |
|
Acifluorfen |
62476599 |
January 1, 1990 |
|
Acrylamide |
79061 |
January 1, 1990 |
|
Acrylonitrile |
107131 |
July 1, 1987 |
|
Actinomycin D |
50760 |
October 1, 1989 |
|
Adriamycin (Doxorubicin hydrochloride) |
23214928 |
July 1, 1987 |
|
AF-2;[2-(2-furyl)-3-(5-nitro-2-furyl)]acrylamide |
3688537 |
July 1, 1987 |
|
Aflatoxins |
--- |
January 1, 1988 |
|
Alachlor |
15972608 |
January 1, 1989 |
|
Alcoholic beverages, when associated with alcohol abuse |
--- |
July 1, 1988 |
|
Aldrin |
309002 |
July 1, 1988 |
|
|
|
|
|
2-Aminoanthraquinone |
117793 |
October 1, 1989 |
|
p-Aminoazobenzene |
60093 |
January 1, 1990 |
|
ortho-Aminoazotoluene |
97563 |
July 1, 1987 |
|
4-Aminobiphenyl (4-aminodiphenyl) |
92671 |
February 27, 1987 |
|
1-Amino-2,4-dibromoanthraquinone |
81492 |
August 26, 1997 |
|
3-Amino-9-ethylcarbazole hydrochloride |
6109973 |
July 1, 1989 |
|
2-Aminofluorene |
153786 |
January 29, 1999 |
|
1-Amino-2-methylanthraquinone |
82280 |
October 1, 1989 |
|
2-Amino-5-(5-nitro-2-furyl)-1,3,4-thiadiazole |
712685 |
July 1, 1987 |
|
4-Amino-2-nitrophenol |
119346 |
January 29, 1999 |
|
Amitrole |
61825 |
July 1, 1987 |
|
Analgesic mixtures containing phenacetin |
--- |
February 27, 1987 |
|
Aniline |
62533 |
January 1, 1990 |
|
Aniline hydrochloride |
142041 |
May 15, 1998 |
|
ortho-Anisidine |
90040 |
July 1, 1987 |
|
ortho-Anisidine hydrochloride |
134292 |
July 1, 1987 |
|
Antimony oxide (Antimony trioxide) |
1309644 |
October 1, 1990 |
|
Aramite |
140578 |
July 1, 1987 |
|
Arsenic (inorganic arsenic compounds) |
--- |
February 27, 1987 |
|
Asbestos |
1332214 |
February 27, 1987 |
|
Auramine |
492808 |
July 1, 1987 |
|
Azacitidine |
320672 |
January 1, 1992 |
|
Azaserine |
115026 |
July 1, 1987 |
|
Azathioprine |
446866 |
February 27, 1987 |
|
Azobenzene |
103333 |
January 1, 1990 |
|
Benz[a]anthracene |
56553 |
July 1, 1987 |
|
Benzene |
71432 |
February 27, 1987 |
|
Benzidine [and its salts] |
92875 |
February 27, 1987 |
|
Benzidine-based dyes |
--- |
October 1, 1992 |
|
Benzo[b]fluoranthene |
205992 |
July 1, 1987 |
|
Benzo[j]fluoranthene |
205823 |
July 1, 1987 |
|
Benzo[k]fluoranthene |
207089 |
July 1, 1987 |
|
Benzofuran |
271896 |
October 1, 1990 |
|
Benzo[a]pyrene |
50328 |
July 1, 1987 |
|
Benzotrichloride |
98077 |
July 1, 1987 |
|
Benzyl chloride |
100447 |
January 1, 1990 |
|
Benzyl violet 4B |
1694093 |
July 1, 1987 |
|
Beryllium and beryllium compounds |
--- |
October 1, 1987 |
|
Betel quid with tobacco |
--- |
January 1, 1990 |
|
2,2-Bis(bromomethyl)-1,3-propanediol |
3296900 |
May 1, 1996 |
|
Bis(2-chloroethyl)ether |
111444 |
April 1, 1988 |
|
N,N-Bis(2-chloroethyl)-2-naphthylamine (Chlornapazine) |
494031 |
February 27, 1987 |
|
Bischloroethyl nitrosourea (BCNU) (Carmustine) |
154938 |
July 1, 1987 |
|
Bis(chloromethyl)ether |
542881 |
February 27, 1987 |
|
Bis(2-chloro-1-methylethyl)ether, technical grade |
--- |
October 29, 1999 |
|
Bitumens, extracts of steam-refined and air refined |
--- |
January 1, 1990 |
|
Bracken fern |
--- |
January 1, 1990 |
| Bromate | 15541454 | May 31, 2002 |
|
Bromodichloromethane |
75274 |
January 1, 1990 |
|
Bromoethane |
74964 |
December 22, 2000 |
|
Bromoform |
75252 |
April 1, 1991 |
|
1,3-Butadiene |
106990 |
April 1, 1988 |
|
1,4-Butanediol dimethanesulfonate (Busulfan) |
55981 |
February 27, 1987 |
|
Butylated hydroxyanisole |
25013165 |
January 1, 1990 |
|
beta-Butyrolactone |
3068880 |
July 1, 1987 |
|
Cacodylic acid |
75605 |
May 1, 1996 |
|
Cadmium and cadmium compounds |
--- |
October 1, 1987 |
|
Caffeic acid |
331395 |
October 1, 1994 |
|
Captafol |
2425061 |
October 1, 1988 |
|
Captan |
133062 |
January 1, 1990 |
|
Carbazole |
86748 |
May 1, 1996 |
|
Carbon tetrachloride |
56235 |
October 1, 1987 |
|
Carbon-black extracts |
--- |
January 1, 1990 |
|
Ceramic fibers (airborne particles of respirable size) |
--- |
July 1, 1990 |
|
Certain combined chemotherapy for lymphomas |
--- |
February 27, 1987 |
|
Chlorambucil |
305033 |
February 27, 1987 |
|
Chloramphenicol |
56757 |
October 1, 1989 |
|
Chlordane |
57749 |
July 1, 1988 |
|
Chlordecone (Kepone) |
143500 |
January 1, 1988 |
|
Chlordimeform |
6164983 |
January 1, 1989 |
|
Chlorendic acid |
115286 |
July 1, 1989 |
|
Chlorinated paraffins (Average chain length, C12; approximately 60 percent chlorine by weight) |
108171262 |
July 1, 1989 |
|
p-Chloroaniline |
106478 |
October 1, 1994 |
|
p-Chloroaniline hydrochloride |
20265967 |
May 15, 1998 |
|
|
|
|
|
Chloroethane (Ethyl chloride) |
75003 |
July 1, 1990 |
|
1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) (Lomustine) |
13010474 |
January 1, 1988 |
|
1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1- nitrosourea (Methyl-CCNU) |
13909096 |
October 1, 1988 |
|
Chloroform |
67663 |
October 1, 1987 |
|
Chloromethyl methyl ether (technical grade) |
107302 |
February 27, 1987 |
|
3-Chloro-2-methylpropene |
563473 |
July 1, 1989 |
|
1-Chloro-4-nitrobenzene |
100005 |
October 29, 1999 |
|
4-Chloro-ortho-phenylenediamine |
95830 |
January 1, 1988 |
|
p-Chloro-o-toluidine |
95692 |
January 1, 1990 |
|
p-Chloro-o-toluidine, strong acid salts of |
--- |
May 15, 1998 |
|
5-Chloro-o-toluidine and its strong acid salts |
--- |
October 24, 1997 |
|
Chloroprene |
126998 |
June 2, 2000 |
|
Chlorothalonil |
1897456 |
January 1, 1989 |
|
Chlorotrianisene |
569573 |
September 1, 1996 |
|
Chlorozotocin |
54749905 |
January 1, 1992 |
|
Chromium (hexavalent compounds) |
--- |
February 27, 1987 |
|
Chrysene |
218019 |
January 1, 1990 |
|
C.I. Acid Red 114 |
6459945 |
July 1, 1992 |
|
C.I. Basic Red 9 monohydrochloride |
569619 |
July 1, 1989 |
|
C.I. Direct Blue 15 |
2429745 |
August 26, 1997 |
|
C.I. Direct Blue 218 |
28407376 |
August 26, 1997 |
|
C.I. Solvent Yellow 14 |
842079 |
May 15, 1998 |
|
Ciclosporin (Cyclosporin A; Cyclosporine) |
59865133 79217600 |
January 1, 1992 |
|
Cidofovir |
113852372 |
January 29, 1999 |
|
Cinnamyl anthranilate |
87296 |
July 1, 1989 |
|
Cisplatin |
15663271 |
October 1, 1988 |
|
Citrus Red No. 2 |
6358538 |
October 1, 1989 |
|
Clofibrate |
637070 |
September 1, 1996 |
|
Cobalt metal powder |
7440484 |
July 1, 1992 |
|
Cobalt [II] oxide |
1307966 |
July 1, 1992 |
| Cobalt sulfate heptahydrate |
10026241 |
June 2, 2000 |
|
Coke oven emissions |
--- |
February 27, 1987 |
|
Conjugated estrogens |
--- |
February 27, 1987 |
|
Creosotes |
--- |
October 1, 1988 |
|
para-Cresidine |
120718 |
January 1, 1988 |
|
Cupferron |
135206 |
January 1, 1988 |
|
Cycasin |
14901087 |
January 1, 1988 |
|
Cyclophosphamide (anhydrous) |
50180 |
February 27, 1987 |
|
Cyclophosphamide (hydrated) |
6055192 |
February 27, 1987 |
|
Cytembena |
21739913 |
May 15, 1998 |
|
D&C Orange No. 17 |
3468631 |
July 1, 1990 |
|
D&C Red No. 8 |
2092560 |
October 1, 1990 |
|
D&C Red No. 9 |
5160021 |
July 1, 1990 |
|
D&C Red No. 19 |
81889 |
July 1, 1990 |
|
Dacarbazine |
4342034 |
January 1, 1988 |
|
Daminozide |
1596845 |
January 1, 1990 |
|
Dantron (Chrysazin; 1,8-Dihydroxyanthraquinone) |
117102 |
January 1, 1992 |
|
Daunomycin |
20830813 |
January 1, 1988 |
|
DDD (Dichlorodiphenyldichloroethane) |
72548 |
January 1, 1989 |
|
DDE (Dichlorodiphenyldichloroethylene) |
72559 |
January 1, 1989 |
|
DDT (Dichlorodiphenyltrichloroethane) |
50293 |
October 1, 1987 |
|
DDVP (Dichlorvos) |
62737 |
January 1, 1989 |
|
N,N'-Diacetylbenzidine |
613354 |
October 1, 1989 |
|
2,4-Diaminoanisole |
615054 |
October 1, 1990 |
|
2,4-Diaminoanisole sulfate |
39156417 |
January 1, 1988 |
|
4,4'-Diaminodiphenyl ether (4,4'-Oxydianiline) |
101804 |
January 1, 1988 |
|
2,4-Diaminotoluene |
95807 |
January 1, 1988 |
|
Diaminotoluene (mixed) |
--- |
January 1, 1990 |
|
Dibenz[a,h]acridine |
226368 |
January 1, 1988 |
|
Dibenz[a,j]acridine |
224420 |
January 1, 1988 |
|
Dibenz[a,h]anthracene |
53703 |
January 1, 1988 |
|
7H-Dibenzo[c,g]carbazole |
194592 |
January 1, 1988 |
|
Dibenzo[a,e]pyrene |
192654 |
January 1, 1988 |
|
Dibenzo[a,h]pyrene |
189640 |
January 1, 1988 |
|
Dibenzo[a,i]pyrene |
189559 |
January 1, 1988 |
|
Dibenzo[a,l]pyrene |
191300 |
January 1, 1988 |
|
1,2-Dibromo-3-chloropropane (DBCP) |
96128 |
July 1, 1987 |
|
2,3-Dibromo-1-propanol |
96139 |
October 1, 1994 |
|
Dichloroacetic acid |
79436 |
May 1, 1996 |
|
p-Dichlorobenzene |
106467 |
January 1, 1989 |
|
3,3'-Dichlorobenzidine |
91941 |
October 1, 1987 |
|
3,3'-Dichlorobenzidine dihydrochloride |
612839 |
May 15, 1998 |
|
1,4-Dichloro-2-butene |
764410 |
January 1, 1990 |
|
3,3'-Dichloro-4,4'-diaminodiphenyl ether |
28434868 |
January 1, 1988 |
|
1,1-Dichloroethane |
75343 |
January 1, 1990 |
|
Dichloromethane (Methylene chloride) |
75092 |
April 1, 1988 |
|
1,2-Dichloropropane |
78875 |
January 1, 1990 |
|
1,3-Dichloropropene |
542756 |
January 1, 1989 |
|
Dieldrin |
60571 |
July 1, 1988 |
|
Dienestrol |
84173 |
January 1, 1990 |
|
Diepoxybutane |
1464535 |
January 1, 1988 |
|
Diesel engine exhaust |
--- |
October 1, 1990 |
|
Di(2-ethylhexyl)phthalate |
117817 |
January 1, 1988 |
|
1,2-Diethylhydrazine |
1615801 |
January 1, 1988 |
|
Diethyl sulfate |
64675 |
January 1, 1988 |
|
Diethylstilbestrol (DES) |
56531 |
February 27, 1987 |
|
Diglycidyl resorcinol ether (DGRE) |
101906 |
July 1, 1989 |
|
Dihydrosafrole |
94586 |
January 1, 1988 |
|
Diisopropyl sulfate |
2973106 |
April 1, 1993 |
|
3,3'-Dimethoxybenzidine (ortho-Dianisidine) |
119904 |
January 1, 1988 |
|
3,3'-Dimethoxybenzidine dihydrochloride (ortho-Dianisidine dihydrochloride) |
20325400 |
October 1, 1990 |
|
Dimethyl sulfate |
77781 |
January 1, 1988 |
|
4-Dimethylaminoazobenzene |
60117 |
January 1, 1988 |
|
trans-2-[(Dimethylamino)methylimino]-5-[2-(5-nitro-2- furyl)vinyl]-1,3,4-oxadiazole |
55738540 |
January 1, 1988 |
|
7,12-Dimethylbenz(a)anthracene |
57976 |
January 1, 1990 |
|
3,3'-Dimethylbenzidine (ortho-Tolidine) |
119937 |
January 1, 1988 |
|
3,3'-Dimethylbenzidine dihydrochloride |
612828 |
April 1, 1992 |
|
Dimethylcarbamoyl chloride |
79447 |
January 1, 1988 |
|
1,1-Dimethylhydrazine (UDMH) |
57147 |
October 1, 1989 |
|
1,2-Dimethylhydrazine |
540738 |
January 1, 1988 |
|
Dimethylvinylchloride |
513371 |
July 1, 1989 |
|
3,7-Dinitrofluoranthene |
105735715 |
August 26, 1997 |
|
3,9-Dinitrofluoranthene |
22506532 |
August 26, 1997 |
|
1,6-Dinitropyrene |
42397648 |
October 1, 1990 |
|
1,8-Dinitropyrene |
42397659 |
October 1, 1990 |
|
Dinitrotoluene mixture, 2,4-/2,6- |
--- |
May 1, 1996 |
|
2,4-Dinitrotoluene |
121142 |
July 1, 1988 |
|
2,6-Dinitrotoluene |
606202 |
July 1, 1995 |
|
Di-n-propyl isocinchomeronate (MGK Repellent 326) |
136458 |
May 1, 1996 |
|
1,4-Dioxane |
123911 |
January 1, 1988 |
|
Diphenylhydantoin (Phenytoin) |
57410 |
January 1, 1988 |
|
Diphenylhydantoin (Phenytoin), sodium salt |
630933 |
January 1, 1988 |
|
Direct Black 38 (technical grade) |
1937377 |
January 1, 1988 |
|
Direct Blue 6 (technical grade) |
2602462 |
January 1, 1988 |
|
Direct Brown 95 (technical grade) |
16071866 |
October 1, 1988 |
|
Disperse Blue 1 |
2475458 |
October 1, 1990 |
| Diuron | 330541 | May 31, 2002 |
|
Epichlorohydrin |
106898 |
October 1, 1987 |
|
Erionite |
12510428 |
October 1, 1988 |
|
Estradiol 17B |
50282 |
January 1, 1988 |
|
Estragole |
140670 |
October 29, 1999 |
|
Estrone |
53167 |
January 1, 1988 |
|
Estropipate |
7280377 |
August 26, 1997 |
|
Ethinylestradiol |
57636 |
January 1, 1988 |
|
Ethoprop |
13194484 |
February 27, 2001 |
|
Ethyl acrylate |
140885 |
July 1, 1989 |
|
Ethyl methanesulfonate |
62500 |
January 1, 1988 |
|
Ethyl-4,4'-dichlorobenzilate |
510156 |
January 1, 1990 |
|
Ethylene dibromide |
106934 |
July 1, 1987 |
|
Ethylene dichloride (1,2-Dichloroethane) |
107062 |
October 1, 1987 |
|
Ethylene oxide |
75218 |
July 1, 1987 |
|
Ethylene thiourea |
96457 |
January 1, 1988 |
|
Ethyleneimine |
151564 |
January 1, 1988 |
| Fenoxycarb |
72490018 |
June 2, 2000 |
|
Folpet |
133073 |
January 1, 1989 |
|
Formaldehyde (gas) |
50000 |
January 1, 1988 |
|
2-(2-Formylhydrazino)-4-(5-nitro-2-furyl)thiazole |
3570750 |
January 1, 1988 |
|
Furan |
110009 |
October 1, 1993 |
|
Furazolidone |
67458 |
January 1, 1990 |
|
Furmecyclox |
60568050 |
January 1, 1990 |
|
Fusarin C |
79748815 |
July 1, 1995 |
|
Ganciclovir sodium |
82410320 |
August 26, 1997 |
|
Gasoline engine exhaust (condensates/extracts) |
--- |
October 1, 1990 |
|
Gemfibrozil |
25812300 |
December 22, 2000 |
|
Glasswool fibers (airborne particles of respirable size) |
--- |
July 1, 1990 |
|
Glu-P-1 (2-Amino-6-methyldipyrido[1,2- a:3',2'-d]imidazole) |
67730114 |
January 1, 1990 |
|
Glu-P-2 (2-Aminodipyrido[1,2-a:3',2'-d]imidazole) |
67730103 |
January 1, 1990 |
|
Glycidaldehyde |
765344 |
January 1, 1988 |
|
Glycidol |
556525 |
July 1, 1990 |
|
Griseofulvin |
126078 |
January 1, 1990 |
|
Gyromitrin (Acetaldehyde methylformylhydrazone) |
16568028 |
January 1, 1988 |
|
HC Blue 1 |
2784943 |
July 1, 1989 |
|
Heptachlor |
76448 |
July 1, 1988 |
|
Heptachlor epoxide |
1024573 |
July 1, 1988 |
|
Hexachlorobenzene |
118741 |
October 1, 1987 |
|
Hexachlorocyclohexane (technical grade) |
--- |
October 1, 1987 |
|
Hexachlorodibenzodioxin |
34465468 |
April 1, 1988 |
|
Hexachloroethane |
67721 |
July 1, 1990 |
|
Hexamethylphosphoramide |
680319 |
January 1, 1988 |
|
Hydrazine |
302012 |
January 1, 1988 |
|
Hydrazine sulfate |
10034932 |
January 1, 1988 |
|
Hydrazobenzene (1,2-Diphenylhydrazine) |
122667 |
January 1, 1988 |
|
Indeno [1,2,3-cd]pyrene |
193395 |
January 1, 1988 |
|
Indium phosphide |
22398807 |
February 27, 2001 |
|
IQ (2-Amino-3-methylimidazo[4,5-f]quinoline) |
76180966 |
April 1, 1990 |
|
Iprodione |
36734197 |
May 1, 1996 |
|
Iron dextran complex |
9004664 |
January 1, 1988 |
|
Isobutyl nitrite |
542563 |
May 1, 1996 |
|
Isoprene |
78795 |
May 1, 1996 |
|
Isosafrole |
120581 |
October 1, 1989 |
|
Isoxaflutole |
141112290 |
December 22, 2000 |
|
Lactofen |
77501634 |
January 1, 1989 |
|
Lasiocarpine |
303344 |
April 1, 1988 |
|
Lead acetate |
301042 |
January 1, 1988 |
|
Lead and lead compounds |
--- |
October 1, 1992 |
|
Lead phosphate |
7446277 |
April 1, 1988 |
|
Lead subacetate |
1335326 |
October 1, 1989 |
|
Lindane and other hexachlorocyclohexane isomers |
--- |
October 1, 1989 |
| Lynestrenol |
52766 |
February 27, 2001 |
|
Mancozeb |
8018017 |
January 1, 1990 |
|
Maneb |
12427382 |
January 1, 1990 |
|
Me-A-alpha-C (2-Amino-3-methyl-9H-pyrido[2,3-b]indole) |
68006837 |
January 1, 1990 |
|
Medroxyprogesterone acetate |
71589 |
January 1, 1990 |
|
MeIQ(2-Amino-3,4-dimethylimidazo[4,5-f]quinoline) |
77094112 |
October 1, 1994 |
|
MeIQx(2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline) |
77500040 |
October 1, 1994 |
|
Melphalan |
148823 |
February 27, 1987 |
|
Merphalan |
531760 |
April 1, 1988 |
|
Mestranol |
72333 |
April 1, 1988 |
|
Metham sodium |
137428 |
November 6, 1998 |
|
8-Methoxypsoralen with ultraviolet A therapy |
298817 |
February 27, 1987 |
|
5-Methoxypsoralen with ultraviolet A therapy |
484208 |
October 1, 1988 |
|
2-Methylaziridine (Propyleneimine) |
75558 |
January 1, 1988 |
|
Methylazoxymethanol |
590965 |
April 1, 1988 |
|
Methylazoxymethanol acetate |
592621 |
April 1, 1988 |
|
Methyl carbamate |
598550 |
May 15, 1998 |
|
3-Methylcholanthrene |
56495 |
January 1, 1990 |
|
5-Methylchrysene |
3697243 |
April 1, 1988 |
|
4,4'-Methylene bis(2-chloroaniline) |
101144 |
July 1, 1987 |
|
4,4'-Methylene bis(N,N-dimethyl)benzenamine |
101611 |
October 1, 1989 |
|
4,4'-Methylene bis(2-methylaniline) |
838880 |
April 1, 1988 |
|
4,4'-Methylenedianiline |
101779 |
January 1, 1988 |
|
4,4'-Methylenedianiline dihydrochloride |
13552448 |
January 1, 1988 |
|
Methyleugenol |
93152 |
November 16, 2001 |
|
Methylhydrazine and its salts |
--- |
July 1, 1992 |
|
Methyl iodide |
74884 |
April 1, 1988 |
|
Methylmercury compounds |
--- |
May 1, 1996 |
|
Methyl methanesulfonate |
66273 |
April 1, 1988 |
|
2-Methyl-1-nitroanthraquinone (of uncertain purity) |
129157 |
April 1, 1988 |
|
N-Methyl-N'-nitro-N-nitrosoguanidine |
70257 |
April 1, 1988 |
|
N-Methylolacrylamide |
924425 |
July 1, 1990 |
|
Methylthiouracil |
56042 |
October 1, 1989 |
|
Metiram |
9006422 |
January 1, 1990 |
|
Metronidazole |
443481 |
January 1, 1988 |
|
Michler's ketone |
90948 |
January 1, 1988 |
|
Mirex |
2385855 |
January 1, 1988 |
|
Mitomycin C |
50077 |
April 1, 1988 |
|
Monocrotaline |
315220 |
April 1, 1988 |
|
5-(Morpholinomethyl)-3-[(5-nitro-furfurylidene)-amino]-2-oxazolidinone |
139913 |
April 1, 1988 |
|
Mustard Gas |
505602 |
February 27, 1987 |
|
MX (3-chloro-4-dichloromethyl-5-hydroxy-2(5H)-furanone) |
77439760 |
December 22, 2000 |
| N-Carboxymethyl-N-nitrosourea | 60391926 | January 25, 2002 |
|
Nafenopin |
3771195 |
April 1, 1988 |
|
Nalidixic acid |
389082 |
May 15, 1998 |
| Naphthalene | 91203 | April 19, 2002 |
|
1-Naphthylamine |
134327 |
October 1, 1989 |
|
2-Naphthylamine |
91598 |
February 27, 1987 |
|
Nickel and certain nickel compounds |
--- |
October 1, 1989 |
|
Nickel carbonyl |
13463393 |
October 1, 1987 |
|
Nickel refinery dust from the pyrometallurgical process |
--- |
October 1, 1987 |
|
Nickel subsulfide |
12035722 |
October 1, 1987 |
|
Niridazole |
61574 |
April 1, 1988 |
|
Nitrilotriacetic acid |
139139 |
January 1, 1988 |
|
Nitrilotriacetic acid, trisodium salt monohydrate |
18662538 |
April 1, 1989 |
|
5-Nitroacenaphthene |
602879 |
April 1, 1988 |
|
5-Nitro-o-anisidine |
99592 |
October 1, 1989 |
|
o-Nitroanisole |
91236 |
October 1, 1992 |
|
Nitrobenzene |
98953 |
August 26, 1997 |
|
4-Nitrobiphenyl |
92933 |
April 1, 1988 |
|
6-Nitrochrysene |
7496028 |
October 1, 1990 |
|
Nitrofen (technical grade) |
1836755 |
January 1, 1988 |
|
2-Nitrofluorene |
607578 |
October 1, 1990 |
|
Nitrofurazone |
59870 |
January 1, 1990 |
|
1-[(5-Nitrofurfurylidene)-amino]-2-imidazolidinone |
555840 |
April 1, 1988 |
|
N-[4-(5-Nitro-2-furyl)-2-thiazolyl]acetamide |
531828 |
April 1, 1988 |
|
Nitrogen mustard (Mechlorethamine) |
51752 |
January 1, 1988 |
|
Nitrogen mustard hydrochloride (Mechlorethamine hydrochloride) |
55867 |
April 1, 1988 |
|
Nitrogen mustard N-oxide |
126852 |
April 1, 1988 |
|
Nitrogen mustard N-oxide hydrochloride |
302705 |
April 1, 1988 |
|
Nitromethane |
75525 |
May 1, 1997 |
|
2-Nitropropane |
79469 |
January 1, 1988 |
|
1-Nitropyrene |
5522430 |
October 1, 1990 |
|
4-Nitropyrene |
57835924 |
October 1, 1990 |
|
N-Nitrosodi-n-butylamine |
924163 |
October 1, 1987 |
|
N-Nitrosodiethanolamine |
1116547 |
January 1, 1988 |
|
N-Nitrosodiethylamine |
55185 |
October 1, 1987 |
|
N-Nitrosodimethylamine |
62759 |
October 1, 1987 |
|
p-Nitrosodiphenylamine |
156105 |
January 1, 1988 |
|
N-Nitrosodiphenylamine |
86306 |
April 1, 1988 |
|
N-Nitrosodi-n-propylamine |
621647 |
January 1, 1988 |
|
N-Nitroso-N-ethylurea |
759739 |
October 1, 1987 |
|
3-(N-Nitrosomethylamino)propionitrile |
60153493 |
April 1, 1990 |
|
4-(N-Nitrosomethylamino)-1-(3-pyridyl)1-butanone |
64091914 |
April 1, 1990 |
|
N-Nitrosomethylethylamine |
10595956 |
October 1, 1989 |
|
N-Nitroso-N-methylurea |
684935 |
October 1, 1987 |
|
N-Nitroso-N-methylurethane |
615532 |
April 1, 1988 |
|
N-Nitrosomethylvinylamine |
4549400 |
January 1, 1988 |
|
N-Nitrosomorpholine |
59892 |
January 1, 1988 |
|
N-Nitrosonornicotine |
16543558 |
January 1, 1988 |
|
N-Nitrosopiperidine |
100754 |
January 1, 1988 |
|
N-Nitrosopyrrolidine |
930552 |
October 1, 1987 |
|
N-Nitrososarcosine |
13256229 |
January 1, 1988 |
|
o-Nitrotoluene |
88722 |
May 15, 1998 |
|
Norethisterone (Norethindrone) |
68224 |
October 1, 1989 |
| Norethynodrel |
68235 |
February 27, 2001 |
|
Ochratoxin A |
303479 |
July 1, 1990 |
|
Oil Orange SS |
2646175 |
April 1, 1988 |
|
Oral contraceptives, combined |
--- |
October 1, 1989 |
|
Oral contraceptives, sequential |
--- |
October 1, 1989 |
|
Oxadiazon |
19666309 |
July 1, 1991 |
|
Oxazepam |
604751 |
October 1, 1994 |
|
Oxymetholone |
434071 |
January 1, 1988 |
|
Oxythioquinox |
2439012 |
August 20, 1999 |
|
Palygorskite fibers (> 5mm in length) |
12174117 |
December 28, 1999 |
|
Panfuran S |
794934 |
January 1, 1988 |
|
Pentachlorophenol |
87865 |
January 1, 1990 |
|
Phenacetin |
62442 |
October 1, 1989 |
|
Phenazopyridine |
94780 |
January 1, 1988 |
|
Phenazopyridine hydrochloride |
136403 |
January 1, 1988 |
|
Phenesterin |
3546109 |
July 1, 1989 |
|
Phenobarbital |
50066 |
January 1, 1990 |
|
Phenolphthalein |
77098 |
May 15, 1998 |
|
Phenoxybenzamine |
59961 |
April 1, 1988 |
|
Phenoxybenzamine hydrochloride |
63923 |
April 1, 1988 |
|
o-Phenylenediamine and its salts |
95545 |
May 15, 1998 |
|
Phenyl glycidyl ether |
122601 |
October 1, 1990 |
|
Phenylhydrazine and its salts |
--- |
July 1, 1992 |
|
o-Phenylphenate, sodium |
132274 |
January 1, 1990 |
|
o-Phenylphenol |
90437 |
August 4, 2000 |
|
PhiP(2-Amino-1-methyl-6-phenylimidazol[4,5-b]pyridine) |
105650235 |
October 1, 1994 |
|
Polybrominated biphenyls |
--- |
January 1, 1988 |
|
Polychlorinated biphenyls |
--- |
October 1, 1989 |
|
Polychlorinated biphenyls (containing 60 or more percent chlorine by molecular weight) |
--- |
January 1, 1988 |
|
Polychlorinated dibenzo-p-dioxins |
--- |
October 1, 1992 |
|
Polychlorinated dibenzofurans |
--- |
October 1, 1992 |
|
Polygeenan |
53973981 |
January 1, 1988 |
|
Ponceau MX |
3761533 |
April 1, 1988 |
|
Ponceau 3R |
3564098 |
April 1, 1988 |
|
Potassium bromate |
7758012 |
January 1, 1990 |
|
Primidone |
125337 |
August 20, 1999 |
|
Procarbazine |
671169 |
January 1, 1988 |
|
Procarbazine hydrochloride |
366701 |
January 1, 1988 |
|
Procymidone |
32809168 |
October 1, 1994 |
|
Progesterone |
57830 |
January 1, 1988 |
| Propachlor |
1918167 |
February 27, 2001 |
|
1,3-Propane sultone |
1120714 |
January 1, 1988 |
|
Propargite |
2312358 |
October 1, 1994 |
|
Pronamide |
23950585 |
May 1, 1996 |
|
beta-Propiolactone |
57578 |
January 1, 1988 |
|
Propylene oxide |
75569 |
October 1, 1988 |
|
Propylthiouracil |
51525 |
January 1, 1988 |
| Pyridine | 110861 | May 17, 2002 |
|
Quinoline and its strong acid salts |
--- |
October 24, 1997 |
|
Radionuclides |
--- |
July 1, 1989 |
|
Reserpine |
50555 |
October 1, 1989 |
|
Residual (heavy) fuel oils |
--- |
October 1, 1990 |
|
|
|
|
|
Saccharin, sodium |
128449 |
January 1, 1988 |
|
Safrole |
94597 |
January 1, 1988 |
|
Salicylazosulfapyridine |
599791 |
May 15, 1998 |
|
Selenium sulfide |
7446346 |
October 1, 1989 |
|
Shale-oils |
68308349 |
April 1, 1990 |
|
Silica, crystalline (airborne particles of respirable size) |
--- |
October 1, 1988 |
|
Soots, tars, and mineral oils (untreated and mildly treated oils and used engine oils) |
--- |
February 27, 1987 |
|
Spironolactone |
52017 |
May 1, 1997 |
|
Stanozolol |
10418038 |
May 1, 1997 |
|
Sterigmatocystin |
10048132 |
April 1, 1988 |
|
Streptozotocin (streptozocin) |
18883664 |
January 1, 1988 |
|
Styrene oxide |
96093 |
October 1, 1988 |
|
Sulfallate |
95067 |
January 1, 1988 |
|
Talc containing asbestiform fibers |
--- |
April 1, 1990 |
|
Tamoxifen and its salts |
10540291 |
September 1, 1996 |
|
Terrazole |
2593159 |
October 1, 1994 |
|
Testosterone and its esters |
58220 |
April 1, 1988 |
|
2,3,7,8-Tetrachlorodibenzo-para-dioxin (TCDD) |
1746016 |
January 1, 1988 |
|
1,1,2,2-Tetrachloroethane |
79345 |
July 1, 1990 |
|
Tetrachloroethylene (Perchloroethylene) |
127184 |
April 1, 1988 |
|
p-a,a,a-Tetrachlorotoluene |
5216251 |
January 1, 1990 |
|
Tetrafluoroethylene |
116143 |
May 1, 1997 |
|
Tetranitromethane |
509148 |
July 1, 1990 |
|
Thioacetamide |
62555 |
January 1, 1988 |
|
4,4'-Thiodianiline |
139651 |
April 1, 1988 |
|
Thiodicarb |
59669260 |
August 20, 1999 |
|
Thiourea |
62566 |
January 1, 1988 |
|
Thorium dioxide |
1314201 |
February 27, 1987 |
|
Tobacco, oral use of smokeless products |
--- |
April 1, 1988 |
|
Tobacco smoke |
--- |
April 1, 1988 |
|
Toluene diisocyanate |
26471625 |
October 1, 1989 |
|
ortho-Toluidine |
95534 |
January 1, 1988 |
|
ortho-Toluidine hydrochloride |
636215 |
January 1, 1988 |
|
|
|
|
|
Toxaphene (Polychlorinated camphenes) |
8001352 |
January 1, 1988 |
|
Treosulfan |
299752 |
February 27, 1987 |
|
Trichlormethine (Trimustine hydrochloride) |
817094 |
January 1, 1992 |
|
Trichloroethylene |
79016 |
April 1, 1988 |
|
2,4,6-Trichlorophenol |
88062 |
January 1, 1988 |
|
1,2,3-Trichloropropane |
96184 |
October 1,1992 |
|
Trimethyl phosphate |
512561 |
May 1, 1996 |
|
2,4,5-Trimethylaniline and its strong acid salts |
--- |
October 24, 1997 |
|
Triphenyltin hydroxide |
76879 |
July 1, 1992 |
|
Tris(aziridinyl)-para-benzoquinone (Triaziquone) |
68768 |
October 1, 1989 |
|
Tris(1-aziridinyl)phosphine sulfide (Thiotepa) |
52244 |
January 1, 1988 |
|
Tris(2-chloroethyl) phosphate |
115968 |
April 1, 1992 |
|
Tris(2,3-dibromopropyl)phosphate |
126727 |
January 1, 1988 |
|
Trp-P-1 (Tryptophan-P-1) |
62450060 |
April 1, 1988 |
|
Trp-P-2 (Tryptophan-P-2) |
62450071 |
April 1, 1988 |
|
Trypan blue (commercial grade) |
72571 |
October 1, 1989 |
|
Unleaded gasoline (wholly vaporized) |
--- |
April 1, 1988 |
|
Uracil mustard |
66751 |
April 1, 1988 |
|
Urethane (Ethyl carbamate) |
51796 |
January 1, 1988 |
|
Vinclozolin |
50471448 |
August 20, 1999 |
|
Vinyl bromide |
593602 |
October 1, 1988 |
|
Vinyl chloride |
75014 |
February 27, 1987 |
|
4-Vinylcyclohexene |
100403 |
May 1, 1996 |
|
4-Vinyl-1-cyclohexene diepoxide (Vinyl cyclohexenedioxide) |
106876 |
July 1, 1990 |
|
Vinyl fluoride |
75025 |
May 1, 1997 |
|
Vinyl trichloride (1,1,2-Trichloroethane) |
79005 |
October 1, 1990 |
|
2,6- Xylidine (2,6-Dimethylaniline) |
87627 |
January 1, 1991 |
|
Zileuton |
111406872 |
December 22, 2000 |
|
|
|
|
CHEMICALS KNOWN TO THE STATE TO CAUSE REPRODUCTIVE TOXICITY
Developmental toxicity
| Acetazolamide |
59665 |
August 20, 1999 |
| Acetohydroxamic acid |
546883 |
April 1, 1990 |
| Actinomycin D |
50760 |
October 1, 1992 |
| All-trans retinoic acid |
302794 |
January 1, 1989 |
| Alprazolam |
28981977 |
July 1, 1990 |
| Altretamine |
645056 |
August 20, 1999 |
| Amantadine hydrochloride |
665667 |
February 27, 2001 |
| Amikacin sulfate |
39831555 |
July 1, 1990 |
| Aminoglutethimide |
125848 |
July 1, 1990 |
| Aminoglycosides |
--- |
October 1, 1992 |
| Aminopterin |
54626 |
July 1, 1987 |
| Amiodarone hydrochloride |
19774824 |
August 26, 1997 |
| Amitraz |
33089611 |
March 30, 1999 |
| Amoxapine |
14028445 |
May 15, 1998 |
| Angiotensin converting enzyme (ACE) inhibitors |
--- |
October 1, 1992 |
| Anisindione |
117373 |
October 1, 1992 |
| Arsenic (inorganic oxides) |
--- |
May 1, 1997 |
| Aspirin (NOTE: It is especially important not to use aspirin during the last three months of pregnancy, unless specifically directed to do so by a physician because it may cause problems in the unborn child or complications during delivery.) |
50782 |
July 1, 1990 |
| Atenolol |
29122687 |
August 26, 1997 |
| Auranofin |
34031328 |
January 29, 1999 |
| Azathioprine |
446866 |
September 1, 1996 |
| Barbiturates |
--- |
October 1, 1992 |
| Beclomethasone dipropionate |
5534098 |
May 15, 1998 |
| Benomyl |
17804352 |
July 1, 1991 |
| Benzene |
71432 |
December 26, 1997 |
| Benzphetamine hydrochloride |
5411223 |
April 1, 1990 |
| Benzodiazepines |
--- |
October 1, 1992 |
| Bischloroethyl nitrosourea (BCNU) (Carmustine) |
154938 |
July 1, 1990 |
| Bromacil lithium salt |
53404196 |
May 18, 1999 |
| Bromoxynil |
1689845 |
October 1, 1990 |
| Bromoxynil octanoate |
1689992 |
May 18, 1999 |
| Butabarbital sodium |
143817 |
October 1, 1992 |
| 1,4-Butanediol dimethanesulfonate (Busulfan) |
55981 |
January 1, 1989 |
| Cadmium |
--- |
May 1, 1997 |
| Carbamazepine |
298464 |
January 29, 1999 |
| Carbon disulfide |
75150 |
July 1, 1989 |
| Carbon monoxide |
630080 |
July 1, 1989 |
| Carboplatin |
41575944 |
July 1, 1990 |
| Chenodiol |
474259 |
April 1, 1990 |
| Chinomethionat (Oxythioquinox) |
2439012 |
November 6, 1998 |
| Chlorambucil |
305033 |
January 1, 1989 |
| Chlorcyclizine hydrochloride |
1620219 |
July 1, 1987 |
| Chlordecone (Kepone) |
143500 |
January 1, 1989 |
| Chlordiazepoxide |
58253 |
January 1, 1992 |
| Chlordiazepoxide hydrochloride |
438415 |
January 1, 1992 |
| 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) (Lomustine) |
13010474 |
July 1, 1990 |
| Chlorsulfuron |
64902723 |
May 14, 1999 |
| Cidofovir |
113852372 |
January 29, 1999 |
| Cladribine |
4291638 |
September 1, 1996 |
| Clarithromycin |
81103119 |
May 1, 1997 |
| Clobetasol propionate |
25122467 |
May 15, 1998 |
| Clomiphene citrate |
50419 |
April 1, 1990 |
| Clorazepate dipotassium |
57109907 |
October 1, 1992 |
| Cocaine |
50362 |
July 1, 1989 |
| Codeine phosphate |
52288 |
May 15, 1998 |
| Colchicine |
64868 |
October 1, 1992 |
| Conjugated estrogens |
--- |
April 1, 1990 |
| Cyanazine |
21725462 |
April 1, 1990 |
| Cycloate |
1134232 |
March 19, 1999 |
| Cycloheximide |
66819 |
January 1, 1989 |
| Cyclophosphamide (anhydrous) |
50180 |
January 1, 1989 |
| Cyclophosphamide (hydrated) |
6055192 |
January 1, 1989 |
| Cyhexatin |
13121705 |
January 1, 1989 |
| Cytarabine |
147944 |
January 1, 1989 |
| Dacarbazine |
4342034 |
January 29, 1999 |
| Danazol |
17230885 |
April 1, 1990 |
| Daunorubicin hydrochloride |
23541506 |
July 1, 1990 |
| |
|
|
| o,p'-DDT |
789026 |
May 15, 1998 |
| p,p'-DDT |
50293 |
May 15, 1998 |
| |
|
|
| Demeclocycline hydrochloride (internal use) |
64733 |
January 1, 1992 |
| Diazepam |
439145 |
January 1, 1992 |
| Diazoxide |
364987 |
February 27, 2001 |
| Dichlorophene |
97234 |
April 27, 1999 |
| Dichlorphenamide |
120978 |
February 27, 2001 |
| Diclofop methyl |
51338273 |
March 5, 1999 |
| Dicumarol |
66762 |
October 1, 1992 |
| Diethylstilbestrol (DES) |
56531 |
July 1, 1987 |
| Diflunisal |
22494424 |
January 29, 1999 |
| Dihydroergotamine mesylate |
6190392 |
May 1, 1997 |
| Diltiazem hydrochloride |
33286225 |
February 27, 2001 |
| Dinocap |
39300453 |
April 1, 1990 |
| Dinoseb |
88857 |
January 1, 1989 |
| Diphenylhydantoin (Phenytoin) |
57410 |
July 1, 1987 |
| Disodium cyanodithiomidocarbonate |
138932 |
March 30, 1999 |
| Doxorubicin hydrochloride |
23214928 |
January 29, 1999 |
| Doxycycline (internal use) |
564250 |
July 1, 1990 |
| Doxycycline calcium (internal use) |
94088854 |
January 1, 1992 |
| Doxycycline hyclate (internal use) |
24390145 |
October 1, 1991 |
| Doxycycline monohydrate (internal use) |
17086281 |
October 1, 1991 |
| Endrin |
72208 |
May 15, 1998 |
| Ergotamine tartrate |
379793 |
April 1, 1990 |
| Estropipate |
7280377 |
August 26, 1997 |
| Ethionamide |
536334 |
August 26, 1997 |
| Ethyl alcohol in alcoholic beverages |
--- |
October 1, 1987 |
| Ethyl dipropylthiocarbamate |
759944 |
April 27, 1999 |
| Ethylene dibromide |
106934 |
May 15, 1998 |
| Ethylene glycol monoethyl ether |
110805 |
January 1, 1989 |
| Ethylene glycol monomethyl ether |
109864 |
January 1, 1989 |
| Ethylene glycol monoethyl ether acetate |
111159 |
January 1, 1993 |
| Ethylene glycol monomethyl ether acetate |
110496 |
January 1, 1993 |
| Ethylene thiourea |
96457 |
January 1, 1993 |
| Etodolac |
41340254 |
August 20, 1999 |
| Etoposide |
33419420 |
July 1, 1990 |
| Etretinate |
54350480 |
July 1, 1987 |
| Fenoxaprop ethyl |
66441234 |
March 26, 1999 |
| Filgrastim |
121181531 |
February 27, 2001 |
| Fluazifop butyl |
69806504 |
November 6, 1998 |
| Flunisolide |
3385033 |
May 15, 1998 |
| Fluorouracil |
51218 |
January 1, 1989 |
| Fluoxymesterone |
76437 |
April 1, 1990 |
| Flurazepam hydrochloride |
1172185 |
October 1, 1992 |
| Flurbiprofen |
5104494 |
August 20, 1999 |
| Flutamide |
13311847 |
July 1, 1990 |
| Fluticasone propionate |
80474142 |
May 15, 1998 |
| Fluvalinate |
69409945 |
November 6, 1998 |
| Ganciclovir sodium |
82410320 |
August 26, 1997 |
| Goserelin acetate |
65807025 |
August 26, 1997 |
| Halazepam |
23092173 |
July 1, 1990 |
| Halobetasol propionate |
66852548 |
August 20, 1999 |
| Haloperidol |
52868 |
January 29, 1999 |
| Halothane |
151677 |
September 1, 1996 |
| Heptachlor |
76448 |
August 20, 1999 |
| Hexachlorobenzene |
118741 |
January 1, 1989 |
| Histrelin acetate |
--- |
May 15, 1998 |
| Hydramethylnon |
67485294 |
March 5, 1999 |
| Hydroxyurea |
127071 |
May 1, 1997 |
| Idarubicin hydrochloride |
57852570 |
August 20, 1999 |
| Ifosfamide |
3778732 |
July 1, 1990 |
| Iodine-131 |
10043660 |
January 1, 1989 |
| Isotretinoin |
4759482 |
July 1, 1987 |
| Lead |
--- |
February 27, 1987 |
| Leuprolide acetate |
74381536 |
August 26, 1997 |
| Levodopa |
59927 |
January 29, 1999 |
| Linuron |
330552 |
March 19, 1999 |
| Lithium carbonate |
554132 |
January 1, 1991 |
| Lithium citrate |
919164 |
January 1, 1991 |
| Lorazepam |
846491 |
July 1, 1990 |
| Lovastatin |
75330755 |
October 1, 1992 |
| Mebendazole |
31431397 |
August 20, 1999 |
| Medroxyprogesterone acetate |
71589 |
April 1, 1990 |
| Megestrol acetate |
595335 |
January 1, 1991 |
| Melphalan |
148823 |
July 1, 1990 |
| Menotropins |
9002680 |
April 1, 1990 |
| Meprobamate |
57534 |
January 1, 1992 |
| Mercaptopurine |
6112761 |
July 1, 1990 |
| Mercury and mercury compounds |
--- |
July 1, 1990 |
| Methacycline hydrochloride |
3963959 |
January 1, 1991 |
| Metham sodium |
137428 |
May 15, 1998 |
| Methazole |
20354261 |
December 1, 1999 |
| Methimazole |
60560 |
July 1, 1990 |
| Methotrexate |
59052 |
January 1, 1989 |
| Methotrexate sodium |
15475566 |
April 1, 1990 |
| Methyl bromide as a structural fumigant |
74839 |
January 1, 1993 |
| Methyl chloride |
74873 |
March 10, 2000 |
| Methyl mercury |
--- |
July 1, 1987 |
| N-Methylpyrrolidone |
872504 |
June 15, 2001 |
| Methyltestosterone |
58184 |
April 1, 1990 |
| Metiram |
9006422 |
March 30, 1999 |
| Midazolam hydrochloride |
59467968 |
July 1, 1990 |
| Minocycline hydrochloride (internal use) |
13614987 |
January 1, 1992 |
| Misoprostol |
59122462 |
April 1, 1990 |
| Mitoxantrone hydrochloride |
70476823 |
July 1, 1990 |
| Myclobutanil |
88671890 |
April 16, 1999 |
| Nabam |
142596 |
March 30, 1999 |
| Nafarelin acetate |
86220420 |
April 1, 1990 |
| Neomycin sulfate (internal use) |
1405103 |
October 1, 1992 |
| Netilmicin sulfate |
56391572 |
July 1, 1990 |
| Nickel carbonyl |
13463393 |
September 1, 1996 |
| Nicotine |
54115 |
April 1, 1990 |
| Nifedipine |
21829254 |
January 29, 1999 |
| Nimodipine |
66085594 |
April 24, 2001 |
| Nitrapyrin |
1929824 |
March 30, 1999 |
| Nitrogen mustard (Mechlorethamine) |
51752 |
January 1, 1989 |
| Nitrogen mustard hydrochloride (Mechlorethamine hydrochloride) |
55867 |
July 1, 1990 |
| Norethisterone (Norethindrone) |
68224 |
April 1, 1990 |
| Norethisterone acetate (Norethindrone acetate) |
51989 |
October 1, 1991 |
| Norethisterone (Norethindrone)/Ethinyl estradiol |
68224/57636 |
April 1, 1990 |
| Norethisterone (Norethindrone)/Mestranol |
68224/72333 |
April 1, 1990 |
| Norgestrel |
6533002 |
April 1, 1990 |
| Oxadiazon |
19666309 |
May 15, 1998 |
| Oxazepam |
604751 |
October 1, 1992 |
| Oxymetholone |
434071 |
May 1, 1997 |
| Oxytetracycline (internal use) |
79572 |
January 1, 1991 |
| Oxytetracycline hydrochloride (internal use) |
2058460 |
October 1, 1991 |
| Paclitaxel |
33069624 |
August 26, 1997 |
| Paramethadione |
115673 |
July 1, 1990 |
| Penicillamine |
52675 |
January 1, 1991 |
| Pentobarbital sodium |
57330 |
July 1, 1990 |
| Pentostatin |
53910251 |
September 1, 1996 |
| Phenacemide |
63989 |
July 1, 1990 |
| Phenprocoumon |
435972 |
October 1, 1992 |
| Pimozide |
2062784 |
August 20, 1999 |
| Pipobroman |
54911 |
July 1, 1990 |
| Plicamycin |
18378897 |
April 1, 1990 |
| Polybrominated biphenyls |
--- |
October 1, 1994 |
| Polychlorinated biphenyls |
--- |
January 1, 1991 |
| Potassium dimethyldithiocarbamate |
128030 |
March 30 1999 |
| Pravastatin sodium |
81131706 |
March 3, 2000 |
| Prednisolone sodium phosphate |
125020 |
August 20, 1999 |
| Procarbazine hydrochloride |
366701 |
July 1, 1990 |
| Propargite |
2312358 |
June 15, 1999 |
| Propylthiouracil |
51525 |
July 1, 1990 |
| Pyrimethamine |
58140 |
January 29, 1999 |
| Quazepam |
36735225 |
August 26, 1997 |
| Resmethrin |
10453868 |
November 6, 1998 |
| Retinol/retinyl esters, when in daily dosages in excess of 10,000 IU, or 3,000 retinol equivalents. (NOTE: Retinol/retinyl esters are required and essential for maintenance of normal reproductive function. The recommended daily level during pregnancy is 8,000 IU.) |
--- |
July 1, 1989 |
| Ribavirin |
36791045 |
April 1, 1990 |
| Rifampin |
13292461 |
February 27, 2001 |
| Secobarbital sodium |
309433 |
October 1, 1992 |
| Sermorelin acetate |
--- |
August 20, 1999 |
| Sodium dimethyldithiocarbamate |
128041 |
March 30 1999 |
| Streptomycin sulfate |
3810740 |
January 1, 1991 |
| Streptozocin (streptozotocin) |
18883664 |
August 20, 1999 |
| Sulindac |
38194502 |
January 29, 1999 |
| Tamoxifen citrate |
54965241 |
July 1, 1990 |
| Temazepam |
846504 |
April 1, 1990 |
| Teniposide |
29767202 |
September 1, 1996 |
| Terbacil |
5902512 |
May 18, 1999 |
| Testosterone cypionate |
58208 |
October 1, 1991 |
| Testosterone enanthate |
315377 |
April 1, 1990 |
| 2,3,7,8-Tetrachlorodibenzo-para-dioxin (TCDD) |
1746016 |
April 1, 1991 |
| Tetracycline (internal use) |
60548 |
October 1, 1991 |
| Tetracyclines (internal use) |
--- |
October 1, 1992 |
| Tetracycline hydrochloride (internal use) |
64755 |
January 1, 1991 |
| Thalidomide |
50351 |
July 1, 1987 |
| Thioguanine |
154427 |
July 1, 1990 |
| Tobacco smoke (primary) |
--- |
April 1, 1988 |
| Tobramycin sulfate |
49842071 |
July 1, 1990 |
| Toluene |
108883 |
January 1, 1991 |
| Triadimefon |
43121433 |
March 30, 1999 |
| Triazolam |
28911015 |
April 1, 1990 |
| Tributyltin methacrylate |
2155706 |
December 1, 1999 |
| Trientine hydrochloride |
38260014 |
February 27, 2001 |
| Triforine |
26644462 |
June 18, 1999 |
| Trilostane |
13647353 |
April 1, 1990 |
| Trimethadione |
127480 |
January 1, 1991 |
| Trimetrexate glucuronate |
82952645 |
August 26, 1997 |
| Triphenyltin hydroxide | 76879 | March 15, 2002 |
| Uracil mustard |
66751 |
January 1, 1992 |
| Urethane |
51796 |
October 1, 1994 |
| Urofollitropin |
26995915 |
April 1, 1990 |
| Valproate (Valproic acid) |
99661 |
July 1, 1987 |
| Vinblastine sulfate |
143679 |
July 1, 1990 |
| Vinclozolin |
50471448 |
May 15, 1998 |
| Vincristine sulfate |
2068782 |
July 1, 1990 |
| Warfarin |
81812 |
July 1, 1987 |
| Zileuton |
111406872 |
December 22, 2000 |
Female reproductive toxicity
| Aminopterin |
54626 |
July 1, 1987 |
| Amiodarone hydrochloride |
19774824 |
August 26, 1997 |
| Anabolic steroids |
--- |
April 1, 1990 |
| Aspirin (NOTE: It is especially important not to use aspirin during the last three months of pregnancy, unless specifically directed to do so by a physician because it may cause problems in the unborn child or complications during delivery.) |
50782 |
July 1, 1990 |
| Carbon disulfide |
75150 |
July 1, 1989 |
| Cidofovir |
113852372 |
January 29, 1999 |
| Chlorsulfuron |
64902723 |
May 14, 1999 |
| Clobetasol propionate |
25122467 |
May 15, 1998 |
| Cocaine |
50362 |
July 1, 1989 |
| Cyclophosphamide (anhydrous) |
50180 |
January 1, 1989 |
| Cyclophosphamide (hydrated) |
6055192 |
January 1, 1989 |
| o,p'-DDT |
789026 |
May 15, 1998 |
| p,p'-DDT |
50293 |
May 15, 1998 |
| Diflunisal |
22494424 |
January 29, 1999 |
| Dinitrotoluene (technical grade) |
--- |
August 20, 1999 |
| Ethylene oxide |
75218 |
February 27, 1987 |
| Etodolac |
41340254 |
August 20, 1999 |
| Flunisolide |
3385033 |
May 15, 1998 |
| Flurbiprofen |
5104494 |
August 20, 1999 |
| Gemfibrozil |
25812300 |
August 20, 1999 |
| Goserelin acetate |
65807025 |
August 26, 1997 |
| Haloperidol |
52868 |
January 29, 1999 |
| Lead |
--- |
February 27, 1987 |
| Leuprolide acetate |
74381536 |
August 26, 1997 |
| Levonorgestrel implants |
797637 |
May 15, 1998 |
| Nifedipine |
21829254 |
January 29, 1999 |
| Oxydemeton methyl |
301122 |
November 6, 1998 |
| Paclitaxel |
33069624 |
August 26, 1997 |
| Pimozide |
2062784 |
August 20, 1999 |
| Rifampin |
13292461 |
February 27, 2001 |
| Streptozocin (streptozotocin) |
18883664 |
August 20, 1999 |
| Sulindac |
38194502 |
January 29, 1999 |
| Thiophanate methyl |
23564058 |
May 18, 1999 |
| Tobacco smoke (primary) |
--- |
April 1, 1988 |
| Triadimefon |
43121433 |
March 30, 1999 |
| Uracil mustard |
66751 |
January 1, 1992 |
| Zileuton |
111406872 |
December 22, 2000 |
Male reproductive toxicity
| Altretamine | 645056 | August 20, 1999 |
| Amiodarone hydrochloride | 19774824 | August 26, 1997 |
| Anabolic steroids | --- | April 1, 1990 |
| Benomyl | 17804352 | July 1, 1991 |
| Benzene | 71432 | December 26, 1997 |
| Cadmium | --- | May 1, 1997 |
| Carbon disulfide | 75150 | July 1, 1989 |
| Cidofovir | 113852372 | January 29, 1999 |
| Chlorsulfuron | 64902723 | May 14, 1999 |
| Colchicine | 64868 | October 1, 1992 |
| |
|
|
| Cyclophosphamide (anhydrous) | 50180 | January 1, 1989 |
| Cyclophosphamide (hydrated) | 6055192 | January 1, 1989 |
| 2,4-D butyric acid | 94826 | June 18, 1999 |
| o,p'-DDT | 789026 | May 15, 1998 |
| p,p'-DDT | 50293 | May 15, 1998 |
| 1,2-Dibromo-3-chloropropane (DBCP) | 96128 | February 27, 1987 |
| m-Dinitrobenzene | 99650 | July 1, 1990 |
| o-Dinitrobenzene | 528290 | July 1, 1990 |
| p-Dinitrobenzene | 100254 | July 1, 1990 |
| 2,4-Dinitrotoluene | 121142 | August 20, 1999 |
| 2,6-Dinitrotoluene | 606202 | August 20, 1999 |
| Dinitrotoluene (technical grade) | --- | August 20, 1999 |
| Dinoseb | 88857 | January 1, 1989 |
| Doxorubicin hydrochloride | 23214928 | January 29, 1999 |
| Epichlorohydrin | 106898 | September 1, 1996 |
| Ethylene dibromide | 106934 | May 15, 1998 |
| Ethylene glycol monoethyl ether | 110805 | January 1, 1989 |
| Ethylene glycol monomethyl ether | 109864 | January 1, 1989 |
| Ethylene glycol monoethyl ether acetate | 111159 | January 1, 1993 |
| Ethylene glycol monomethyl ether acetate | 110496 | January 1, 1993 |
| Ganciclovir sodium | 82410320 | August 26, 1997 |
| Gemfibrozil | 25812300 | August 20, 1999 |
| Goserelin acetate | 65807025 | August 26, 1997 |
| Hexamethylphosphoramide | 680319 | October 1, 1994 |
| Hydramethylnon | 67485294 | March 5, 1999 |
| Idarubicin hydrochloride | 57852570 | August 20, 1999 |
| Lead | --- | February 27, 1987 |
| Leuprolide acetate | 74381536 | August 26, 1997 |
| Myclobutanil | 88671890 | April 16, 1999 |
| Nifedipine | 21829254 | January 29, 1999 |
| Nitrofurantoin | 67209 | April 1, 1991 |
| Oxydemeton methyl | 301122 | November 6, 1998 |
| Paclitaxel | 33069624 | August 26, 1997 |
| Quizalofop-ethyl | 76578148 | December 24, 1999 |
| Ribavirin | 36791045 | February 27, 2001 |
| Sodium fluoroacetate | 62748 | November 6, 1998 |
| Streptozocin (streptozotocin) | 18883664 | August 20, 1999 |
| Sulfasalazine | 599791 | January 29, 1999 |
| Thiophanate methyl | 23564058 | May 18, 1999 |
| Tobacco smoke (primary) | --- | April 1, 1988 |
| Triadimefon | 43121433 | March 30, 1999 |
| Uracil mustard | 66751 | January 1, 1992 |
Date: June 28, 2002