STATE OF CALIFORNIA

ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF ENVIRONMENTAL HEALTH HAZARD ASSESSMENT

SAFE DRINKING WATER AND TOXIC ENFORCEMENT ACT OF 1986

CHEMICALS KNOWN TO THE STATE TO CAUSE CANCER OR REPRODUCTIVE TOXICITY

MARCH 14, 2003

The Safe Drinking Water and Toxic Enforcement Act of 1986 requires that the Governor revise and republish at least once per year the list of chemicals known to the State to cause cancer or reproductive toxicity.  The identification number indicated in the following list is the Chemical Abstracts Service (CAS) Registry Number.  No CAS number is given when several substances are presented as a single listing.  The date refers to the initial appearance of the chemical on the list.  For easy reference, chemicals which are shown underlined are newly added.  Chemicals or endpoints shown in strikeout were placed on the Proposition 65 list on the date noted, and have subsequently been removed. 


Chemical

Type of Toxicity

CAS No.

Date Listed

       

A-alpha-C (2-Amino-9H-pyrido
   [2,3-b]indole)

cancer

26148685

January 1, 1990

Acetaldehyde

cancer

75070

April 1, 1988

Acetamide

cancer

60355

January 1, 1990

Acetazolamide

developmental

59665

August 20, 1999

Acetochlor

cancer

34256821

January 1, 1989

Acetohydroxamic acid

developmental

546883

April 1, 1990

2-Acetylaminofluorene

cancer

53963

July 1, 1987

Acifluorfen

cancer

62476599

January 1, 1990

Acrylamide

cancer

79061

January 1, 1990

Acrylonitrile

cancer

107131

July 1, 1987

Actinomycin D

cancer

50760

October 1, 1989

 

developmental

 

October 1, 1992

Adriamycin (Doxorubicin hydrochloride)

cancer

23214928

July 1, 1987

AF-2;[2-(2-furyl)-3-(5-nitro-2-furyl)] acrylamide

cancer

3688537

July 1, 1987

Aflatoxins

cancer

---

January 1, 1988

Alachlor

cancer

15972608

January 1, 1989

Alcoholic beverages, when associated
   with alcohol abuse

cancer

---

July 1, 1988

Aldrin

cancer

309002

July 1, 1988

All-trans retinoic acid

developmental

302794

January 1, 1989

Allyl chloride

Delisted October 29, 1999

cancer

107051

January 1, 1990

Alprazolam

developmental

28981977

July 1, 1990

Altretamine

developmental, male

645056

August 20, 1999

Amantadine hydrochloride

developmental

665667

February 27, 2001

Amikacin sulfate

developmental

39831555

July 1, 1990

2-Aminoanthraquinone

cancer

117793

October 1, 1989

p-Aminoazobenzene

cancer

60093

January 1, 1990

o-Aminoazotoluene

cancer

97563

July 1, 1987

4-Aminobiphenyl (4-amino-diphenyl)

cancer

92671

February 27, 1987

1-Amino-2,4-dibromo-anthraquinone

cancer

81492

August 26, 1997

3-Amino-9-ethylcarbazole hydrochloride

cancer

6109973

July 1, 1989

2-Aminofluorene

cancer

153786

January 29, 1999

Aminoglutethimide

developmental

125848

July 1, 1990

Aminoglycosides

developmental

---

October 1, 1992

1-Amino-2-methylanthraquinone

cancer

82280

October 1, 1989

2-Amino-5-(5-nitro-2-furyl)-1,3,4-thiadiazole

cancer

712685

July 1, 1987

4-Amino-2-nitrophenol

cancer

119346

January 29, 1999

Aminopterin

developmental, female

54626

July 1, 1987

Amiodarone hydrochloride

developmental, female, male

19774824

August 26, 1997

Amitraz

developmental

33089611

March 30, 1999

Amitrole

cancer

61825

July 1, 1987

Amoxapine

developmental

14028445

May 15, 1998

Anabolic steroids

female, male

---

April 1, 1990

Analgesic mixtures containing phenacetin

cancer

---

February 27, 1987

Angiotensin converting enzyme (ACE) inhibitors

developmental

---

October 1, 1992

Aniline

cancer

62533

January 1, 1990

Aniline hydrochloride

cancer

142041

May 15, 1998

o-Anisidine

cancer

90040

July 1, 1987

o-Anisidine hydrochloride

cancer

134292

July 1, 1987

Anisindione

developmental

117373

October 1, 1992

Antimony oxide (Antimony trioxide)

cancer

1309644

October 1, 1990

Aramite

cancer

140578

July 1, 1987

Arsenic (inorganic arsenic compounds)

cancer

--

February 27, 1987

Arsenic (inorganic oxides)

developmental

---

May 1, 1997

Asbestos

cancer

1332214

February 27, 1987

Aspirin (NOTE:  It is especially important not to use aspirin during the last three months of pregnancy, unless specifically directed to do so
by a physician because it may cause problems in the unborn child or complications during delivery.)

developmental, female

50782

July 1, 1990

Atenolol

developmental

29122687

August 26, 1997

Auramine

cancer

492808

July 1, 1987

Auranofin

developmental

34031328

January 29, 1999

Azacitidine

cancer

320672

January 1, 1992

Azaserine

cancer

115026

July 1, 1987

Azathioprine

cancer
developmental

446866

February 27, 1987
September 1, 1996

Azobenzene

cancer

103333

January 1, 1990

       
       

Barbiturates

developmental

---

October 1, 1992

Beclomethasone dipropionate

developmental

5534098

May 15, 1998

Benomyl

developmental, male

17804352

July 1, 1991

Benz[a]anthracene

cancer

56553

July 1, 1987

Benzene

cancer
developmental, male

71432

February 27, 1987
December 26, 1997

Benzidine [and its salts]

cancer

92875

February 27, 1987

Benzidine-based dyes

cancer

---

October 1, 1992

Benzodiazepines

developmental

---

October 1, 1992

Benzo[b]fluoranthene

cancer

205992

July 1, 1987

Benzo[j]fluoranthene

cancer

205823

July 1, 1987

Benzo[k]fluoranthene

cancer

207089

July 1, 1987

Benzofuran

cancer

271896

October 1, 1990

Benzo[a]pyrene

cancer

50328

July 1, 1987

Benzotrichloride

cancer

98077

July 1, 1987

Benzphetamine hydrochloride

developmental

5411223

April 1, 1990

Benzyl chloride

cancer

100447

January 1, 1990

Benzyl violet 4B

cancer

1694093

July 1, 1987

Beryllium and beryllium compounds

cancer

---

October 1, 1987

Betel quid with tobacco

cancer

---

January 1, 1990

2,2-Bis(bromomethyl)-1,3-propanediol

cancer

3296900

May 1, 1996

Bis(2-chloroethyl)ether

cancer

111444

April 1, 1988

N,N-Bis(2-chloroethyl)-2-naphthylamine (Chlornapazine)

cancer

494031

February 27, 1987

Bischloroethyl nitrosourea (BCNU) (Carmustine)

cancer
developmental

154938

July 1, 1987
July 1, 1990

Bis(chloromethyl)ether

cancer

542881

February 27, 1987

Bis(2-chloro-1-methylethyl)ether, technical grade

cancer

---

October 29, 1999

Bitumens, extracts of steam-refined and air refined

cancer

---

January 1, 1990

Bracken fern

cancer

---

January 1, 1990

Bromacil lithium salt

developmental

53404196

May 18, 1999

 

male

 

January 17, 2003

Bromate

cancer

15541454

May 31, 2002

Bromodichloromethane

cancer

75274

January 1, 1990

Bromoethane

cancer

74964

December 22, 2000

Bromoform

cancer

75252

April 1, 1991

Bromoxynil

developmental

1689845

October 1, 1990

Bromoxynil octanoate

developmental

1689992

May 18, 1999

Butabarbital sodium

developmental

143817

October 1, 1992

1,3-Butadiene

cancer

106990

April 1, 1988

1,4-Butanediol dimethanesulfonate(Busulfan)

cancer
developmental

55981

February 27, 1987
January 1, 1989

Butylated hydroxyanisole

cancer

25013165

January 1, 1990

beta-Butyrolactone

cancer

3068880

July 1, 1987

       

Cacodylic acid

cancer

75605

May 1, 1996

Cadmium

developmental, male

---

May 1, 1997

Cadmium and cadmium compounds

cancer

---

October 1, 1987

Caffeic acid

cancer

331395

October 1, 1994

Captafol

cancer

2425061

October 1, 1988

Captan

cancer

133062

January 1, 1990

Carbamazepine

developmental

298464

January 29, 1999

Carbazole

cancer

86748

May 1, 1996

Carbon black (airborne, unbound particles of respirable size)

cancer

1333864

February 21, 2003

Carbon disulfide

developmental, female, male

75150

July 1, 1989

Carbon monoxide

developmental

630080

July 1, 1989

Carbon tetrachloride

cancer

56235

October 1, 1987

Carbon-black extracts

cancer

---

January 1, 1990

Carboplatin

developmental

41575944

July 1, 1990

N-Carboxymethyl-N-nitrosourea

cancer

60391926

January 25, 2002

Ceramic fibers (airborne particles of respirable size)

cancer

---

July 1, 1990

Certain combined chemotherapy for lymphomas

cancer

---

February 27, 1987

Chenodiol

developmental

474259

April 1, 1990

Chinomethionat (Oxythioquinox)

developmental

2439012

November 6, 1998

Chlorambucil

cancer
developmental

305033

February 27, 1987
January 1, 1989

Chloramphenicol

cancer

56757

October 1, 1989

Chlorcyclizine hydrochloride

developmental

1620219

July 1, 1987

Chlordane

cancer

57749

July 1, 1988

Chlordecone (Kepone)

cancer
developmental

143500

January 1, 1988
January 1, 1989

Chlordiazepoxide

developmental

58253

January 1, 1992

Chlordiazepoxide hydrochloride

developmental

438415

January 1, 1992

Chlordimeform

cancer

6164983

January 1, 1989

Chlorendic acid

cancer

115286

July 1, 1989

Chlorinated paraffins (Average chain length, C12;approximately 60 percent chlorine by weight)

cancer

108171262

July 1, 1989

p-Chloroaniline

cancer

106478

October 1, 1994

p-Chloroaniline hydrochloride

cancer

20265967

May 15, 1998

Chlorodibromomethane 

   Delisted October 29, 1999

cancer

124481

January 1, 1990

Chloroethane (Ethyl chloride)

cancer

75003

July 1, 1990

1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) (Lomustine)

cancer
developmental

13010474

January 1, 1988
July 1, 1990

1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea (Methyl-CCNU)

cancer

13909096

October 1, 1988

Chloroform

cancer

67663

October 1, 1987

Chloromethyl methyl ether (technical grade)

cancer

107302

February 27, 1987

3-Chloro-2-methylpropene

cancer

563473

July 1, 1989

1-Chloro-4-nitrobenzene

cancer

100005

October 29, 1999

4-Chloro-o-phenylenediamine

cancer

95830

January 1, 1988

Chloroprene

cancer

126998

June 2, 2000

Chlorothalonil

cancer

1897456

January 1, 1989

p-Chloro-o-toluidine

cancer

95692

January 1, 1990

p-Chloro-o-toluidine, strong acid salts of

cancer

---

May 15, 1998

5-Chloro-o-toluidine and its strong acid salts

cancer

---

October 24, 1997

Chlorotrianisene

cancer

569573

September 1, 1996

Chlorozotocin

cancer

54749905

January 1, 1992

Chlorsulfuron

developmental, female, male

64902723

May 14, 1999

Chromium (hexavalent compounds)

cancer

---

February 27, 1987

Chrysene

cancer

218019

January 1, 1990

C.I. Acid Red 114

cancer

6459945

July 1, 1992

C.I. Basic Red 9 monohydrochloride

cancer

569619

July 1, 1989

C.I. Direct Blue 15

cancer

2429745

August 26, 1997

C.I. Direct Blue 218

cancer

28407376

August 26, 1997

C.I. Solvent Yellow 14

cancer

842079

May 15, 1998

Ciclosporin (Cyclosporin A; Cyclosporine)

cancer

59865133
79217600

January 1, 1992

Cidofovir

cancer, developmental,
female, male

113852372

January 29, 1999

Cinnamyl anthranilate

cancer

87296

July 1, 1989

Cisplatin

cancer

15663271

October 1, 1988

Citrus Red No. 2

cancer

6358538

October 1, 1989

Cladribine

developmental

4291638

September 1, 1996

Clarithromycin

developmental

81103119

May 1, 1997

Clobetasol propionate

developmental, female

25122467

May 15, 1998

Clofibrate

cancer

637070

September 1, 1996

Clomiphene citrate

developmental

50419

April 1, 1990

Clorazepate dipotassium

developmental

57109907

October 1, 1992

Cobalt metal powder

cancer

7440484

July 1, 1992

Cobalt [II] oxide

cancer

1307966

July 1, 1992

Cobalt sulfate heptahydrate

cancer

10026241

June 2, 2000

Cocaine

developmental, female

50362

July 1, 1989

Codeine phosphate

developmental

52288

May 15, 1998

Coke oven emissions

cancer

---

February 27, 1987

Colchicine

developmental, male

64868

October 1, 1992

Conjugated estrogens

cancer
developmental

---

February 27, 1987
April 1, 1990

Creosotes

cancer

---

October 1, 1988

p-Cresidine

cancer

120718

January 1, 1988

Cupferron

cancer

135206

January 1, 1988

Cyanazine

developmental

21725462

April 1, 1990

Cycasin

cancer

14901087

January 1, 1988

Cycloate

developmental

1134232

March 19, 1999

Cyclohexanol  Delisted January 25, 2002

male

108930

November 6, 1998

Cycloheximide

developmental

66819

January 1, 1989

Cyclophosphamide (anhydrous)

cancer
developmental, female, male

50180

February 27, 1987
January 1, 1989

Cyclophosphamide (hydrated)

cancer
developmental, female, male

6055192

February 27, 1987
January 1, 1989

Cyhexatin

developmental

13121705

January 1, 1989

Cytarabine

developmental

147944

January 1, 1989

Cytembena

cancer

21739913

May 15, 1998

       

D&C Orange No. 17

cancer

3468631

July 1, 1990

D&C Red No. 8

cancer

2092560

October 1, 1990

D&C Red No. 9

cancer

5160021

July 1, 1990

D&C Red No. 19

cancer

81889

July 1, 1990

Dacarbazine

cancer
developmental

4342034

January 1, 1988
January 29, 1999

Daminozide

cancer

1596845

January 1, 1990

Danazol

developmental

17230885

April 1, 1990

Dantron (Chrysazin; 1,8-Dihydroxy anthraquinone)

cancer

117102

January 1, 1992

Daunomycin

cancer

20830813

January 1, 1988

Daunorubicin hydrochloride

developmental

23541506

July 1, 1990

2,4-D butyric acid

developmental, male

94826

June 18, 1999

DDD (Dichlorodiphenyldichloroethane)

cancer

72548

January 1, 1989

DDE (Dichlorodiphenyldichloroethylene)

cancer

72559

January 1, 1989

DDT (Dichlorodiphenyltrichloroethane)

cancer

50293

October 1 , 1987

o,p'-DDT

developmental, female, male

789026

May 15, 1998

p,p'-DDT

developmental, female, male

50293

May 15, 1998

DDVP (Dichlorvos)

cancer

62737

January 1, 1989

2,4-DP (dichloroprop)

Delisted January 25, 2002

developmental

120365

April 27, 1999

N,N'-Diacetylbenzidine

cancer

613354

October 1, 1989

2,4-Diaminoanisole

cancer

615054

October 1, 1990

2,4-Diaminoanisole sulfate

cancer

39156417

January 1, 1988

4,4'-Diaminodiphenyl ether(4,4'-Oxydianiline)

cancer

101804

January 1, 1988

2,4-Diaminotoluene

cancer

95807

January 1, 1988

Demeclocycline hydrochloride(internal use)

developmental

64733

January 1, 1992

Diaminotoluene (mixed)

cancer

---

January 1, 1990

Diazepam

developmental

439145

January 1, 1992

Diazoxide

developmental

364987

February 27, 2001

Dibenz[a,h]acridine

cancer

226368

January 1, 1988

Dibenz[a,j]acridine

cancer

224420

January 1, 1988

Dibenz[a,h]anthracene

cancer

53703

January 1, 1988

7H-Dibenzo[c,g]carbazole

cancer

194592

January 1, 1988

Dibenzo[a,e]pyrene

cancer

192654

January 1, 1988

Dibenzo[a,h]pyrene

cancer

189640

January 1, 1988

Dibenzo[a,i]pyrene

cancer

189559

January 1, 1988

Dibenzo[a,l]pyrene

cancer

191300

January 1, 1988

1,2-Dibromo-3-chloropropane (DBCP)

cancer
male

96128

July 1, 1987
February 27, 1987

2,3-Dibromo-1-propanol

cancer

96139

October 1, 1994

Dichloroacetic acid

cancer

79436

May 1, 1996

p-Dichlorobenzene

cancer

106467

January 1, 1989

3,3'-Dichlorobenzidine

cancer

91941

October 1, 1987

3,3'-Dichlorobenzidine dihydrochloride

cancer

612839

May 15, 1998

1,4-Dichloro-2-butene

cancer

764410

January 1, 1990

3,3'-Dichloro-4,4'-diaminodiphenyl ether

cancer

28434868

January 1, 1988

1,1-Dichloroethane

cancer

75343

January 1, 1990

Dichloromethane (Methylene chloride)

cancer

75092

April 1, 1988

Dichlorophene

developmental

97234

April 27, 1999

Dichlorphenamide

developmental

120978

February 27, 2001

Diclofop methyl

developmental

51338273

March 5, 1999

1,2-Dichloropropane

cancer

78875

January 1, 1990

1,3-Dichloropropene

cancer

542756

January 1, 1989

Dicumarol

developmental

66762

October 1, 1992

Dieldrin

cancer

60571

July 1, 1988

Dienestrol

cancer

84173

January 1, 1990

Diepoxybutane

cancer

1464535

January 1, 1988

Diesel engine exhaust

cancer

---

October 1, 1990

Di(2-ethylhexyl)phthalate

cancer

117817

January 1, 1988

1,2-Diethylhydrazine

cancer

1615801

January 1, 1988

Diethylstilbestrol (DES)

cancer
developmental

56531

February 27, 1987
July 1, 1987

Diethyl sulfate

cancer

64675

January 1, 1988

Diflunisal

developmental, female

22494424

January 29, 1999

Diglycidyl resorcinol ether (DGRE)

cancer

101906

July 1, 1989

Dihydroergotamine mesylate

developmental

6190392

May 1, 1997

Dihydrosafrole

cancer

94586

January 1, 1988

Diisopropyl sulfate

cancer

2973106

April 1, 1993

Diltiazem hydrochloride

developmental

33286225

February 27, 2001

3,3'-Dimethoxybenzidine (o-Dianisidine)

cancer

119904

January 1, 1988

3,3'-Dimethoxybenzidine dihydrochloride(o-Dianisidine dihydrochloride)

cancer

20325400

October 1, 1990

4-Dimethylaminoazobenzene

cancer

60117

January 1, 1988

trans-2-[(Dimethylamino)methyl-imino]-5-[2-(5-nitro-2-furyl)vinyl]-1,3,4-oxadiazole

cancer

55738540

January 1, 1988

7,12-Dimethylbenz(a)anthracene

cancer

57976

January 1, 1990

3,3'-Dimethylbenzidine (ortho-Tolidine)

cancer

119937

January 1, 1988

3,3'-Dimethylbenzidine dihydrochloride

cancer

612828

April 1, 1992

Dimethylcarbamoyl chloride

cancer

79447

January 1, 1988

1,1-Dimethylhydrazine (UDMH)

cancer

57147

October 1, 1989

1,2-Dimethylhydrazine

cancer

540738

January 1, 1988

Dimethyl sulfate

cancer

77781

January 1, 1988

Dimethylvinylchloride

cancer

513371

July 1, 1989

m-Dinitrobenzene

male

99650

July 1, 1990

o-Dinitrobenzene

male

528290

July 1, 1990

p-Dinitrobenzene

male

100254

July 1, 1990

3,7-Dinitrofluoranthene

cancer

105735715

August 26, 1997

3,9-Dinitrofluoranthene

cancer

22506532

August 26, 1997

1,6-Dinitropyrene

cancer

42397648

October 1, 1990

1,8-Dinitropyrene

cancer

42397659

October 1, 1990

Dinitrotoluene (technical grade)

female, male

---

August 20, 1999

Dinitrotoluene mixture, 2,4-/2,6-

cancer

---

May 1, 1996

2,4-Dinitrotoluene

cancer
male

121142

July 1, 1988
August 20, 1999

2,6-Dinitrotoluene

cancer
male

606202

July 1, 1995
August 20, 1999

Dinocap

developmental

39300453

April 1, 1990