STATE OF CALIFORNIA
ENVIRONMENTAL PROTECTION AGENCY
OFFICE OF ENVIRONMENTAL HEALTH HAZARD ASSESSMENT
SAFE DRINKING WATER AND TOXIC ENFORCEMENT ACT OF 1986
CHEMICALS KNOWN TO THE STATE TO CAUSE CANCER OR REPRODUCTIVE TOXICITY
FEBRUARY 21, 2003
The Safe Drinking Water and Toxic Enforcement Act of 1986 requires that the Governor revise and republish at least once per year the list of chemicals known to the State to cause cancer or reproductive toxicity. The identification number indicated in the following list is the Chemical Abstracts Service (CAS) Registry Number. No CAS number is given when several substances are presented as a single listing. The date refers to the initial appearance of the chemical on the list. For easy reference, chemicals which are shown underlined are newly added. Chemicals which are shown with a strikeout were placed on the list with the date noted, and have subsequently been removed.
CHEMICALS KNOWN TO THE STATE TO CAUSE CANCER
|
Chemical |
CAS Number |
Date |
|
A-alpha-C (2-Amino-9H-pyrido[2,3-b]indole) |
26148685 |
January 1, 1990 |
|
Acetaldehyde |
75070 |
April 1, 1988 |
|
Acetamide |
60355 |
January 1, 1990 |
|
Acetochlor |
34256821 |
January 1, 1989 |
|
2-Acetylaminofluorene |
53963 |
July 1, 1987 |
|
Acifluorfen |
62476599 |
January 1, 1990 |
|
Acrylamide |
79061 |
January 1, 1990 |
|
Acrylonitrile |
107131 |
July 1, 1987 |
|
Actinomycin D |
50760 |
October 1, 1989 |
|
Adriamycin (Doxorubicin hydrochloride) |
23214928 |
July 1, 1987 |
|
AF-2;[2-(2-furyl)-3-(5-nitro-2-furyl)]acrylamide |
3688537 |
July 1, 1987 |
|
Aflatoxins |
--- |
January 1, 1988 |
|
Alachlor |
15972608 |
January 1, 1989 |
|
Alcoholic beverages, when associated with alcohol abuse |
--- |
July 1, 1988 |
|
Aldrin |
309002 |
July 1, 1988 |
|
|
|
|
|
2-Aminoanthraquinone |
117793 |
October 1, 1989 |
|
p-Aminoazobenzene |
60093 |
January 1, 1990 |
|
ortho-Aminoazotoluene |
97563 |
July 1, 1987 |
|
4-Aminobiphenyl (4-aminodiphenyl) |
92671 |
February 27, 1987 |
|
1-Amino-2,4-dibromoanthraquinone |
81492 |
August 26, 1997 |
|
3-Amino-9-ethylcarbazole hydrochloride |
6109973 |
July 1, 1989 |
|
2-Aminofluorene |
153786 |
January 29, 1999 |
|
1-Amino-2-methylanthraquinone |
82280 |
October 1, 1989 |
|
2-Amino-5-(5-nitro-2-furyl)-1,3,4-thiadiazole |
712685 |
July 1, 1987 |
|
4-Amino-2-nitrophenol |
119346 |
January 29, 1999 |
|
Amitrole |
61825 |
July 1, 1987 |
|
Analgesic mixtures containing phenacetin |
--- |
February 27, 1987 |
|
Aniline |
62533 |
January 1, 1990 |
|
Aniline hydrochloride |
142041 |
May 15, 1998 |
|
ortho-Anisidine |
90040 |
July 1, 1987 |
|
ortho-Anisidine hydrochloride |
134292 |
July 1, 1987 |
|
Antimony oxide (Antimony trioxide) |
1309644 |
October 1, 1990 |
|
Aramite |
140578 |
July 1, 1987 |
|
Arsenic (inorganic arsenic compounds) |
--- |
February 27, 1987 |
|
Asbestos |
1332214 |
February 27, 1987 |
|
Auramine |
492808 |
July 1, 1987 |
|
Azacitidine |
320672 |
January 1, 1992 |
|
Azaserine |
115026 |
July 1, 1987 |
|
Azathioprine |
446866 |
February 27, 1987 |
|
Azobenzene |
103333 |
January 1, 1990 |
|
Benz[a]anthracene |
56553 |
July 1, 1987 |
|
Benzene |
71432 |
February 27, 1987 |
|
Benzidine [and its salts] |
92875 |
February 27, 1987 |
|
Benzidine-based dyes |
--- |
October 1, 1992 |
|
Benzo[b]fluoranthene |
205992 |
July 1, 1987 |
|
Benzo[j]fluoranthene |
205823 |
July 1, 1987 |
|
Benzo[k]fluoranthene |
207089 |
July 1, 1987 |
|
Benzofuran |
271896 |
October 1, 1990 |
|
Benzo[a]pyrene |
50328 |
July 1, 1987 |
|
Benzotrichloride |
98077 |
July 1, 1987 |
|
Benzyl chloride |
100447 |
January 1, 1990 |
|
Benzyl violet 4B |
1694093 |
July 1, 1987 |
|
Beryllium and beryllium compounds |
--- |
October 1, 1987 |
|
Betel quid with tobacco |
--- |
January 1, 1990 |
|
2,2-Bis(bromomethyl)-1,3-propanediol |
3296900 |
May 1, 1996 |
|
Bis(2-chloroethyl)ether |
111444 |
April 1, 1988 |
|
N,N-Bis(2-chloroethyl)-2-naphthylamine (Chlornapazine) |
494031 |
February 27, 1987 |
|
Bischloroethyl nitrosourea (BCNU) (Carmustine) |
154938 |
July 1, 1987 |
|
Bis(chloromethyl)ether |
542881 |
February 27, 1987 |
| Bis(2-chloro-1-methylethyl)ether, technical grade | --- | October 29, 1999 |
|
Bitumens, extracts of steam-refined and air refined |
--- |
January 1, 1990 |
|
Bracken fern |
--- |
January 1, 1990 |
|
Bromate |
15541454 |
May 31, 2002 |
|
Bromodichloromethane |
75274 |
January 1, 1990 |
| Bromoethane | 74964 | December 22, 2000 |
|
Bromoform |
75252 |
April 1, 1991 |
|
1,3-Butadiene |
106990 |
April 1, 1988 |
|
1,4-Butanediol dimethanesulfonate (Busulfan) |
55981 |
February 27, 1987 |
|
Butylated hydroxyanisole |
25013165 |
January 1, 1990 |
|
beta-Butyrolactone |
3068880 |
July 1, 1987 |
|
Cacodylic acid |
75605 |
May 1, 1996 |
|
Cadmium and cadmium compounds |
--- |
October 1, 1987 |
|
Caffeic acid |
331395 |
October 1, 1994 |
|
Captafol |
2425061 |
October 1, 1988 |
|
Captan |
133062 |
January 1, 1990 |
|
Carbazole |
86748 |
May 1, 1996 |
|
Carbon black (airborne, unbound particles of respirable size) |
1333864 |
February 21, 2003 |
|
Carbon tetrachloride |
56235 |
October 1, 1987 |
|
Carbon-black extracts |
--- |
January 1, 1990 |
|
N-Carboxymethyl-N-nitrosourea |
60391926 |
January 25, 2002 |
|
Ceramic fibers (airborne particles of respirable size) |
--- |
July 1, 1990 |
|
Certain combined chemotherapy for lymphomas |
--- |
February 27, 1987 |
|
Chlorambucil |
305033 |
February 27, 1987 |
|
Chloramphenicol |
56757 |
October 1, 1989 |
|
Chlordane |
57749 |
July 1, 1988 |
|
Chlordecone (Kepone) |
143500 |
January 1, 1988 |
|
Chlordimeform |
6164983 |
January 1, 1989 |
|
Chlorendic acid |
115286 |
July 1, 1989 |
|
Chlorinated paraffins (Average chain length, C12; approximately 60 percent chlorine by weight) |
108171262 |
July 1, 1989 |
|
p-Chloroaniline |
106478 |
October 1, 1994 |
|
p-Chloroaniline hydrochloride |
20265967 |
May 15, 1998 |
|
|
|
|
|
Chloroethane (Ethyl chloride) |
75003 |
July 1, 1990 |
|
1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) (Lomustine) |
13010474 |
January 1, 1988 |
|
1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1- nitrosourea (Methyl-CCNU) |
13909096 |
October 1, 1988 |
|
Chloroform |
67663 |
October 1, 1987 |
|
Chloromethyl methyl ether (technical grade) |
107302 |
February 27, 1987 |
|
3-Chloro-2-methylpropene |
563473 |
July 1, 1989 |
|
1-Chloro-4-nitrobenzene |
100005 |
October 29, 1999 |
|
4-Chloro-ortho-phenylenediamine |
95830 |
January 1, 1988 |
|
p-Chloro-o-toluidine |
95692 |
January 1, 1990 |
|
p-Chloro-o-toluidine, strong acid salts of |
--- |
May 15, 1998 |
|
5-Chloro-o-toluidine and its strong acid salts |
--- |
October 24, 1997 |
|
Chloroprene |
126998 |
June 2, 2000 |
|
Chlorothalonil |
1897456 |
January 1, 1989 |
|
Chlorotrianisene |
569573 |
September 1, 1996 |
|
Chlorozotocin |
54749905 |
January 1, 1992 |
|
Chromium (hexavalent compounds) |
--- |
February 27, 1987 |
|
Chrysene |
218019 |
January 1, 1990 |
|
C.I. Acid Red 114 |
6459945 |
July 1, 1992 |
|
C.I. Basic Red 9 monohydrochloride |
569619 |
July 1, 1989 |
|
C.I. Direct Blue 15 |
2429745 |
August 26, 1997 |
|
C.I. Direct Blue 218 |
28407376 |
August 26, 1997 |
|
C.I. Solvent Yellow 14 |
842079 |
May 15, 1998 |
|
Ciclosporin (Cyclosporin A; Cyclosporine) |
59865133, 79217600 |
January 1, 1992 |
|
Cidofovir |
113852372 |
January 29, 1999 |
|
Cinnamyl anthranilate |
87296 |
July 1, 1989 |
|
Cisplatin |
15663271 |
October 1, 1988 |
|
Citrus Red No. 2 |
6358538 |
October 1, 1989 |
|
Clofibrate |
637070 |
September 1, 1996 |
|
Cobalt metal powder |
7440484 |
July 1, 1992 |
|
Cobalt [II] oxide |
1307966 |
July 1, 1992 |
|
Cobalt sulfate heptahydrate |
10026241 |
June 2, 2000 |
|
Coke oven emissions |
--- |
February 27, 1987 |
|
Conjugated estrogens |
--- |
February 27, 1987 |
|
Creosotes |
--- |
October 1, 1988 |
|
para-Cresidine |
120718 |
January 1, 1988 |
|
Cupferron |
135206 |
January 1, 1988 |
|
Cycasin |
14901087 |
January 1, 1988 |
|
Cyclophosphamide (anhydrous) |
50180 |
February 27, 1987 |
|
Cyclophosphamide (hydrated) |
6055192 |
February 27, 1987 |
|
Cytembena |
21739913 |
May 15, 1998 |
|
D&C Orange No. 17 |
3468631 |
July 1, 1990 |
|
D&C Red No. 8 |
2092560 |
October 1, 1990 |
|
D&C Red No. 9 |
5160021 |
July 1, 1990 |
|
D&C Red No. 19 |
81889 |
July 1, 1990 |
|
Dacarbazine |
4342034 |
January 1, 1988 |
|
Daminozide |
1596845 |
January 1, 1990 |
|
Dantron (Chrysazin; 1,8-Dihydroxyanthraquinone) |
117102 |
January 1, 1992 |
|
Daunomycin |
20830813 |
January 1, 1988 |
|
DDD (Dichlorodiphenyldichloroethane) |
72548 |
January 1, 1989 |
|
DDE (Dichlorodiphenyldichloroethylene) |
72559 |
January 1, 1989 |
|
DDT (Dichlorodiphenyltrichloroethane) |
50293 |
October 1, 1987 |
|
DDVP (Dichlorvos) |
62737 |
January 1, 1989 |
|
N,N'-Diacetylbenzidine |
613354 |
October 1, 1989 |
|
2,4-Diaminoanisole |
615054 |
October 1, 1990 |
|
2,4-Diaminoanisole sulfate |
39156417 |
January 1, 1988 |
|
4,4'-Diaminodiphenyl ether (4,4'-Oxydianiline) |
101804 |
January 1, 1988 |
|
2,4-Diaminotoluene |
95807 |
January 1, 1988 |
|
Diaminotoluene (mixed) |
--- |
January 1, 1990 |
|
Dibenz[a,h]acridine |
226368 |
January 1, 1988 |
|
Dibenz[a,j]acridine |
224420 |
January 1, 1988 |
|
Dibenz[a,h]anthracene |
53703 |
January 1, 1988 |
|
7H-Dibenzo[c,g]carbazole |
194592 |
January 1, 1988 |
|
Dibenzo[a,e]pyrene |
192654 |
January 1, 1988 |
|
Dibenzo[a,h]pyrene |
189640 |
January 1, 1988 |
|
Dibenzo[a,i]pyrene |
189559 |
January 1, 1988 |
|
Dibenzo[a,l]pyrene |
191300 |
January 1, 1988 |
|
1,2-Dibromo-3-chloropropane (DBCP) |
96128 |
July 1, 1987 |
|
2,3-Dibromo-1-propanol |
96139 |
October 1, 1994 |
|
Dichloroacetic acid |
79436 |
May 1, 1996 |
|
p-Dichlorobenzene |
106467 |
January 1, 1989 |
|
3,3'-Dichlorobenzidine |
91941 |
October 1, 1987 |
|
3,3'-Dichlorobenzidine dihydrochloride |
612839 |
May 15, 1998 |
|
1,4-Dichloro-2-butene |
764410 |
January 1, 1990 |
|
3,3'-Dichloro-4,4'-diaminodiphenyl ether |
28434868 |
January 1, 1988 |
|
1,1-Dichloroethane |
75343 |
January 1, 1990 |
|
Dichloromethane (Methylene chloride) |
75092 |
April 1, 1988 |
|
1,2-Dichloropropane |
78875 |
January 1, 1990 |
|
1,3-Dichloropropene |
542756 |
January 1, 1989 |
|
Dieldrin |
60571 |
July 1, 1988 |
|
Dienestrol |
84173 |
January 1, 1990 |
|
Diepoxybutane |
1464535 |
January 1, 1988 |
|
Diesel engine exhaust |
--- |
October 1, 1990 |
|
Di(2-ethylhexyl)phthalate |
117817 |
January 1, 1988 |
|
1,2-Diethylhydrazine |
1615801 |
January 1, 1988 |
|
Diethyl sulfate |
64675 |
January 1, 1988 |
|
Diethylstilbestrol (DES) |
56531 |
February 27, 1987 |
|
Diglycidyl resorcinol ether (DGRE) |
101906 |
July 1, 1989 |
|
Dihydrosafrole |
94586 |
January 1, 1988 |
|
Diisopropyl sulfate |
2973106 |
April 1, 1993 |
|
3,3'-Dimethoxybenzidine (ortho-Dianisidine) |
119904 |
January 1, 1988 |
|
3,3'-Dimethoxybenzidine dihydrochloride (ortho-Dianisidine dihydrochloride) |
20325400 |
October 1, 1990 |
|
Dimethyl sulfate |
77781 |
January 1, 1988 |
|
4-Dimethylaminoazobenzene |
60117 |
January 1, 1988 |
|
trans-2-[(Dimethylamino)methylimino]-5-[2-(5-nitro-2- furyl)vinyl]-1,3,4-oxadiazole |
55738540 |
January 1, 1988 |
|
7,12-Dimethylbenz(a)anthracene |
57976 |
January 1, 1990 |
|
3,3'-Dimethylbenzidine (ortho-Tolidine) |
119937 |
January 1, 1988 |
|
3,3'-Dimethylbenzidine dihydrochloride |
612828 |
April 1, 1992 |
|
Dimethylcarbamoyl chloride |
79447 |
January 1, 1988 |
|
1,1-Dimethylhydrazine (UDMH) |
57147 |
October 1, 1989 |
|
1,2-Dimethylhydrazine |
540738 |
January 1, 1988 |
|
Dimethylvinylchloride |
513371 |
July 1, 1989 |
|
3,7-Dinitrofluoranthene |
105735715 |
August 26, 1997 |
|
3,9-Dinitrofluoranthene |
22506532 |
August 26, 1997 |
|
1,6-Dinitropyrene |
42397648 |
October 1, 1990 |
|
1,8-Dinitropyrene |
42397659 |
October 1, 1990 |
|
Dinitrotoluene mixture, 2,4-/2,6- |
--- |
May 1, 1996 |
|
2,4-Dinitrotoluene |
121142 |
July 1, 1988 |
|
2,6-Dinitrotoluene |
606202 |
July 1, 1995 |
|
Di-n-propyl isocinchomeronate (MGK Repellent 326) |
136458 |
May 1, 1996 |
|
1,4-Dioxane |
123911 |
January 1, 1988 |
|
Diphenylhydantoin (Phenytoin) |
57410 |
January 1, 1988 |
|
Diphenylhydantoin (Phenytoin), sodium salt |
630933 |
January 1, 1988 |
|
Direct Black 38 (technical grade) |
1937377 |
January 1, 1988 |
|
Direct Blue 6 (technical grade) |
2602462 |
January 1, 1988 |
|
Direct Brown 95 (technical grade) |
16071866 |
October 1, 1988 |
|
Disperse Blue 1 |
2475458 |
October 1, 1990 |
|
Diuron |
330541 |
May 31, 2002 |
|
Epichlorohydrin |
106898 |
October 1, 1987 |
|
Erionite |
12510428 |
October 1, 1988 |
|
Estradiol 17B |
50282 |
January 1, 1988 |
| Estragole | 140670 | October 29, 1999 |
|
Estrone |
53167 |
January 1, 1988 |
|
Estropipate |
7280377 |
August 26, 1997 |
|
Ethinylestradiol |
57636 |
January 1, 1988 |
|
Ethoprop |
13194484 |
February 27, 2001 |
|
Ethyl acrylate |
140885 |
July 1, 1989 |
|
Ethyl methanesulfonate |
62500 |
January 1, 1988 |
|
Ethyl-4,4'-dichlorobenzilate |
510156 |
January 1, 1990 |
|
Ethylene dibromide |
106934 |
July 1, 1987 |
|
Ethylene dichloride (1,2-Dichloroethane) |
107062 |
October 1, 1987 |
|
Ethylene oxide |
75218 |
July 1, 1987 |
|
Ethylene thiourea |
96457 |