STATE OF CALIFORNIA
ENVIRONMENTAL PROTECTION
AGENCY
OFFICE OF ENVIRONMENTAL
HEALTH HAZARD ASSESSMENT
SAFE DRINKING WATER AND
TOXIC ENFORCEMENT ACT OF 1986
CHEMICALS KNOWN TO THE STATE
TO CAUSE CANCER OR REPRODUCTIVE TOXICITY
FEBRUARY 14, 2003
The Safe Drinking Water and Toxic Enforcement
Act of 1986 requires that the Governor revise and republish at least once per
year the list of chemicals known to the State to cause cancer or reproductive
toxicity. The identification number
indicated in the following list is the Chemical Abstracts Service (CAS)
Registry Number. No CAS number is given
when several substances are presented as a single listing. The date refers to the initial appearance of
the chemical on the list. For easy
reference, chemicals which are shown underlined are newly added. Chemicals which are shown with a strikeout
were placed on the list with the date noted, and have subsequently been
removed.
CHEMICALS KNOWN TO THE STATE TO CAUSE CANCER
|
Chemical |
CAS Number |
Date |
|
|
|
|
|
A-alpha-C
(2-Amino-9H-pyrido[2,3-b]indole) |
26148685 |
January 1, 1990 |
|
Acetaldehyde |
75070 |
April 1, 1988 |
|
Acetamide |
60355 |
January 1, 1990 |
|
Acetochlor |
34256821 |
January 1, 1989 |
|
2-Acetylaminofluorene |
53963 |
July 1, 1987 |
|
Acifluorfen |
62476599 |
January 1, 1990 |
|
Acrylamide |
79061 |
January 1, 1990 |
|
Acrylonitrile |
107131 |
July 1, 1987 |
|
Actinomycin D |
50760 |
October 1, 1989 |
|
Adriamycin (Doxorubicin
hydrochloride) |
23214928 |
July 1, 1987 |
|
AF-2;[2-(2-furyl)-3-(5-nitro-2-furyl)]acrylamide |
3688537 |
July 1, 1987 |
|
Aflatoxins |
--- |
January 1, 1988 |
|
Alachlor |
15972608 |
January 1, 1989 |
|
Alcoholic beverages, when
associated with alcohol abuse |
--- |
July 1, 1988 |
|
Aldrin |
309002 |
July 1, 1988 |
|
|
|
|
|
2-Aminoanthraquinone |
117793 |
October 1, 1989 |
|
p-Aminoazobenzene |
60093 |
January 1, 1990 |
|
ortho-Aminoazotoluene |
97563 |
July 1, 1987 |
|
4-Aminobiphenyl (4-aminodiphenyl) |
92671 |
February 27, 1987 |
|
1-Amino-2,4-dibromoanthraquinone |
81492 |
August 26, 1997 |
|
3-Amino-9-ethylcarbazole
hydrochloride |
6109973 |
July 1, 1989 |
|
2-Aminofluorene |
153786 |
January 29, 1999 |
|
1-Amino-2-methylanthraquinone |
82280 |
October 1, 1989 |
|
2-Amino-5-(5-nitro-2-furyl)-1,3,4-thiadiazole |
712685 |
July 1, 1987 |
|
4-Amino-2-nitrophenol |
119346 |
January 29, 1999 |
|
Amitrole |
61825 |
July 1, 1987 |
|
Analgesic mixtures containing
phenacetin |
--- |
February 27, 1987 |
|
Aniline |
62533 |
January 1, 1990 |
|
Aniline hydrochloride |
142041 |
May 15, 1998 |
|
ortho-Anisidine |
90040 |
July 1, 1987 |
|
ortho-Anisidine
hydrochloride |
134292 |
July 1, 1987 |
|
Antimony oxide (Antimony
trioxide) |
1309644 |
October 1, 1990 |
|
Aramite |
140578 |
July 1, 1987 |
|
Arsenic (inorganic arsenic
compounds) |
--- |
February 27, 1987 |
|
Asbestos |
1332214 |
February 27, 1987 |
|
Auramine |
492808 |
July 1, 1987 |
|
Azacitidine |
320672 |
January 1, 1992 |
|
Azaserine |
115026 |
July 1, 1987 |
|
Azathioprine |
446866 |
February 27, 1987 |
|
Azobenzene |
103333 |
January 1, 1990 |
|
|
|
|
|
Benz[a]anthracene |
56553 |
July 1, 1987 |
|
Benzene |
71432 |
February 27, 1987 |
|
Benzidine [and its salts] |
92875 |
February 27, 1987 |
|
Benzidine-based dyes |
--- |
October 1, 1992 |
|
Benzo[b]fluoranthene |
205992 |
July 1, 1987 |
|
Benzo[j]fluoranthene |
205823 |
July 1, 1987 |
|
Benzo[k]fluoranthene |
207089 |
July 1, 1987 |
|
Benzofuran |
271896 |
October 1, 1990 |
|
Benzo[a]pyrene |
50328 |
July 1, 1987 |
|
Benzotrichloride |
98077 |
July 1, 1987 |
|
Benzyl chloride |
100447 |
January 1, 1990 |
|
Benzyl violet 4B |
1694093 |
July 1, 1987 |
|
Beryllium and beryllium
compounds |
--- |
October 1, 1987 |
|
Betel quid with tobacco |
--- |
January 1, 1990 |
|
2,2-Bis(bromomethyl)-1,3-propanediol |
3296900 |
May 1, 1996 |
|
Bis(2-chloroethyl)ether |
111444 |
April 1, 1988 |
|
N,N-Bis(2-chloroethyl)-2-naphthylamine
(Chlornapazine) |
494031 |
February 27, 1987 |
|
Bischloroethyl nitrosourea
(BCNU) (Carmustine) |
154938 |
July 1, 1987 |
|
Bis(chloromethyl)ether |
542881 |
February 27, 1987 |
Bis(2-chloro-1-methylethyl)ether,
technical grade
|
---
|
October
29, 1999
|
|
Bitumens, extracts of
steam-refined and air refined |
--- |
January 1, 1990 |
|
Bracken fern |
--- |
January 1, 1990 |
|
Bromate |
15541454 |
May 31, 2002 |
|
Bromodichloromethane |
75274 |
January 1, 1990 |
Bromoethane
|
74964
|
December
22, 2000
|
|
Bromoform |
75252 |
April 1, 1991 |
|
1,3-Butadiene |
106990 |
April 1, 1988 |
|
1,4-Butanediol
dimethanesulfonate (Busulfan) |
55981 |
February 27, 1987 |
|
Butylated hydroxyanisole |
25013165 |
January 1, 1990 |
|
beta-Butyrolactone |
3068880 |
July 1, 1987 |
|
|
|
|
|
Cacodylic acid |
75605 |
May 1, 1996 |
|
Cadmium and cadmium
compounds |
--- |
October 1, 1987 |
|
Caffeic
acid |
331395 |
October
1, 1994 |
|
Captafol |
2425061 |
October 1, 1988 |
|
Captan |
133062 |
January 1, 1990 |
|
Carbazole |
86748 |
May 1, 1996 |
|
Carbon tetrachloride |
56235 |
October 1, 1987 |
|
Carbon-black extracts |
--- |
January 1, 1990 |
|
N-Carboxymethyl-N-nitrosourea |
60391926 |
January 25, 2002 |
|
Ceramic fibers (airborne
particles of respirable size) |
--- |
July 1, 1990 |
|
Certain combined
chemotherapy for lymphomas |
--- |
February 27, 1987 |
|
Chlorambucil |
305033 |
February 27, 1987 |
|
Chloramphenicol |
56757 |
October 1, 1989 |
|
Chlordane |
57749 |
July 1, 1988 |
|
Chlordecone (Kepone) |
143500 |
January 1, 1988 |
|
Chlordimeform |
6164983 |
January 1, 1989 |
|
Chlorendic acid |
115286 |
July 1, 1989 |
|
Chlorinated paraffins (Average chain length, C12; approximately 60 percent chlorine by weight) |
108171262 |
July 1, 1989 |
|
p-Chloroaniline |
106478 |
October 1, 1994 |
|
p-Chloroaniline
hydrochloride |
20265967 |
May 15, 1998 |
|
|
|
|
|
Chloroethane (Ethyl
chloride) |
75003 |
July 1, 1990 |
|
1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea
(CCNU) (Lomustine) |
13010474 |
January 1, 1988 |
|
1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-
nitrosourea (Methyl-CCNU) |
13909096 |
October 1, 1988 |
|
Chloroform |
67663 |
October 1, 1987 |
|
Chloromethyl methyl ether
(technical grade) |
107302 |
February 27, 1987 |
|
3-Chloro-2-methylpropene |
563473 |
July 1, 1989 |
|
1-Chloro-4-nitrobenzene |
100005 |
October 29, 1999 |
|
4-Chloro-ortho-phenylenediamine |
95830 |
January 1, 1988 |
|
p-Chloro-o-toluidine |
95692 |
January 1, 1990 |
|
p-Chloro-o-toluidine,
strong acid salts of |
--- |
May 15, 1998 |
|
5-Chloro-o-toluidine and
its strong acid salts |
--- |
October 24, 1997 |
|
Chloroprene |
126998 |
June 2, 2000 |
|
Chlorothalonil |
1897456 |
January 1, 1989 |
|
Chlorotrianisene |
569573 |
September 1, 1996 |
|
Chlorozotocin |
54749905 |
January 1, 1992 |
|
Chromium (hexavalent
compounds) |
--- |
February 27, 1987 |
|
Chrysene |
218019 |
January 1, 1990 |
|
C.I. Acid Red 114 |
6459945 |
July 1, 1992 |
|
C.I. Basic Red 9
monohydrochloride |
569619 |
July 1, 1989 |
|
C.I. Direct Blue 15 |
2429745 |
August 26, 1997 |
|
C.I. Direct Blue 218 |
28407376 |
August 26, 1997 |
|
C.I. Solvent Yellow 14 |
842079 |
May 15, 1998 |
|
Ciclosporin (Cyclosporin
A; Cyclosporine) |
59865133, 79217600 |
January 1, 1992 |
|
|
|
|
|
Cidofovir |
113852372 |
January 29, 1999 |
|
Cinnamyl anthranilate |
87296 |
July 1, 1989 |
|
Cisplatin |
15663271 |
October 1, 1988 |
|
Citrus Red No. 2 |
6358538 |
October 1, 1989 |
|
Clofibrate |
637070 |
September 1, 1996 |
|
Cobalt metal powder |
7440484 |
July 1, 1992 |
|
Cobalt [II] oxide |
1307966 |
July 1, 1992 |
|
Cobalt sulfate
heptahydrate |
10026241 |
June 2, 2000 |
|
Coke oven emissions |
--- |
February 27, 1987 |
|
Conjugated estrogens |
--- |
February 27, 1987 |
|
Creosotes |
--- |
October 1, 1988 |
|
para-Cresidine |
120718 |
January 1, 1988 |
|
Cupferron |
135206 |
January 1, 1988 |
|
Cycasin |
14901087 |
January 1, 1988 |
|
Cyclophosphamide
(anhydrous) |
50180 |
February 27, 1987 |
|
Cyclophosphamide
(hydrated) |
6055192 |
February 27, 1987 |
|
Cytembena |
21739913 |
May 15, 1998 |
|
|
|
|
|
D&C Orange No. 17 |
3468631 |
July 1, 1990 |
|
D&C Red No. 8 |
2092560 |
October 1, 1990 |
|
D&C Red No. 9 |
5160021 |
July 1, 1990 |
|
D&C Red No. 19 |
81889 |
July 1, 1990 |
|
Dacarbazine |
4342034 |
January 1, 1988 |
|
Daminozide |
1596845 |
January 1, 1990 |
|
Dantron (Chrysazin;
1,8-Dihydroxyanthraquinone) |
117102 |
January 1, 1992 |
|
Daunomycin |
20830813 |
January 1, 1988 |
|
DDD
(Dichlorodiphenyldichloroethane) |
72548 |
January 1, 1989 |
|
DDE
(Dichlorodiphenyldichloroethylene) |
72559 |
January 1, 1989 |
|
DDT (Dichlorodiphenyltrichloroethane) |
50293 |
October 1, 1987 |
|
DDVP (Dichlorvos) |
62737 |
January 1, 1989 |
|
N,N'-Diacetylbenzidine |
613354 |
October 1, 1989 |
|
2,4-Diaminoanisole |
615054 |
October 1, 1990 |
|
2,4-Diaminoanisole sulfate |
39156417 |
January 1, 1988 |
|
4,4'-Diaminodiphenyl ether
(4,4'-Oxydianiline) |
101804 |
January 1, 1988 |
|
2,4-Diaminotoluene |
95807 |
January 1, 1988 |
|
Diaminotoluene (mixed) |
--- |
January 1, 1990 |
|
Dibenz[a,h]acridine |
226368 |
January 1, 1988 |
|
Dibenz[a,j]acridine |
224420 |
January 1, 1988 |
|
Dibenz[a,h]anthracene |
53703 |
January 1, 1988 |
|
7H-Dibenzo[c,g]carbazole |
194592 |
January 1, 1988 |
|
Dibenzo[a,e]pyrene |
192654 |
January 1, 1988 |
|
Dibenzo[a,h]pyrene |
189640 |
January 1, 1988 |
|
Dibenzo[a,i]pyrene |
189559 |
January 1, 1988 |
|
Dibenzo[a,l]pyrene |
191300 |
January 1, 1988 |
|
1,2-Dibromo-3-chloropropane
(DBCP) |
96128 |
July 1, 1987 |
|
2,3-Dibromo-1-propanol |
96139 |
October 1, 1994 |
|
Dichloroacetic acid |
79436 |
May 1, 1996 |
|
p-Dichlorobenzene |
106467 |
January 1, 1989 |
|
3,3'-Dichlorobenzidine |
91941 |
October 1, 1987 |
|
3,3'-Dichlorobenzidine
dihydrochloride |
612839 |
May 15, 1998 |
|
1,4-Dichloro-2-butene |
764410 |
January 1, 1990 |
|
3,3'-Dichloro-4,4'-diaminodiphenyl
ether |
28434868 |
January 1, 1988 |
|
1,1-Dichloroethane |
75343 |
January 1, 1990 |
|
Dichloromethane (Methylene
chloride) |
75092 |
April 1, 1988 |
|
1,2-Dichloropropane |
78875 |
January 1, 1990 |
|
1,3-Dichloropropene |
542756 |
January 1, 1989 |
|
Dieldrin |
60571 |
July 1, 1988 |
|
Dienestrol |
84173 |
January 1, 1990 |
|
Diepoxybutane |
1464535 |
January 1, 1988 |
|
Diesel engine exhaust |
--- |
October 1, 1990 |
|
Di(2-ethylhexyl)phthalate |
117817 |
January 1, 1988 |
|
1,2-Diethylhydrazine |
1615801 |
January 1, 1988 |
|
Diethyl sulfate |
64675 |
January 1, 1988 |
|
Diethylstilbestrol (DES) |
56531 |
February 27, 1987 |
|
Diglycidyl resorcinol
ether (DGRE) |
101906 |
July 1, 1989 |
|
Dihydrosafrole |
94586 |
January 1, 1988 |
|
Diisopropyl sulfate |
2973106 |
April 1, 1993 |
|
3,3'-Dimethoxybenzidine
(ortho-Dianisidine) |
119904 |
January 1, 1988 |
|
3,3'-Dimethoxybenzidine
dihydrochloride (ortho-Dianisidine dihydrochloride) |
20325400 |
October 1, 1990 |
|
Dimethyl sulfate |
77781 |
January 1, 1988 |
|
4-Dimethylaminoazobenzene |
60117 |
January 1, 1988 |
|
trans-2-[(Dimethylamino)methylimino]-5-[2-(5-nitro-2- furyl)vinyl]-1,3,4-oxadiazole |
55738540 |
January 1, 1988 |
|
7,12-Dimethylbenz(a)anthracene |
57976 |
January 1, 1990 |
|
3,3'-Dimethylbenzidine
(ortho-Tolidine) |
119937 |
January 1, 1988 |
|
3,3'-Dimethylbenzidine
dihydrochloride |
612828 |
April 1, 1992 |
|
Dimethylcarbamoyl chloride |
79447 |
January 1, 1988 |
|
1,1-Dimethylhydrazine
(UDMH) |
57147 |
October 1, 1989 |
|
1,2-Dimethylhydrazine |
540738 |
January 1, 1988 |
|
Dimethylvinylchloride |
513371 |
July 1, 1989 |
|
3,7-Dinitrofluoranthene |
105735715 |
August 26, 1997 |
|
3,9-Dinitrofluoranthene |
22506532 |
August 26, 1997 |
|
1,6-Dinitropyrene |
42397648 |
October 1, 1990 |
|
1,8-Dinitropyrene |
42397659 |
October 1, 1990 |
|
Dinitrotoluene mixture,
2,4-/2,6- |
--- |
May 1, 1996 |
|
2,4-Dinitrotoluene |
121142 |
July 1, 1988 |
|
2,6-Dinitrotoluene |
606202 |
July 1, 1995 |
|
Di-n-propyl
isocinchomeronate (MGK Repellent 326) |
136458 |
May 1, 1996 |
|
1,4-Dioxane |
123911 |
January 1, 1988 |
|
Diphenylhydantoin
(Phenytoin) |
57410 |
January 1, 1988 |
|
Diphenylhydantoin
(Phenytoin), sodium salt |
630933 |
January 1, 1988 |
|
Direct Black 38 (technical
grade) |
1937377 |
January 1, 1988 |
|
Direct Blue 6 (technical
grade) |
2602462 |
January 1, 1988 |
|
Direct Brown 95 (technical
grade) |
16071866 |
October 1, 1988 |
|
Disperse Blue 1 |
2475458 |
October 1, 1990 |
|
Diuron |
330541 |
May 31, 2002 |
|
|
|
|
|
Epichlorohydrin |
106898 |
October 1, 1987 |
|
Erionite |
12510428 |
October 1, 1988 |
|
Estradiol 17B |
50282 |
January 1, 1988 |
Estragole
|
140670
|
October
29, 1999
|
|
Estrone |
53167 |
January 1, 1988 |
|
Estropipate |
7280377 |
August 26, 1997 |
|
Ethinylestradiol |
57636 |
January 1, 1988 |
|
Ethoprop |
13194484 |
February 27, 2001 |
|
Ethyl acrylate |
140885 |
July 1, 1989 |
|
Ethyl methanesulfonate |
62500 |
January 1, 1988 |
|
Ethyl-4,4'-dichlorobenzilate |
510156 |
January 1, 1990 |
|
Ethylene dibromide |
106934 |
July 1, 1987 |
|
Ethylene dichloride
(1,2-Dichloroethane) |
107062 |
October 1, 1987 |
|
Ethylene oxide |
75218 |
July 1, 1987 |
|
Ethylene thiourea |
96457 |
January 1, 1988 |
|
Ethyleneimine |
151564 |
January 1, 1988 |
|
|
|
|
|
Fenoxycarb |
72490018 |
June 2, 2000 |
|
Folpet |
133073 |
January 1, 1989 |
|
Formaldehyde (gas) |
50000 |
January 1, 1988 |
|
2-(2-Formylhydrazino)-4-(5-nitro-2-furyl)thiazole |
3570750 |
January 1, 1988 |
|
Furan |
110009 |
October 1, 1993 |
|
Furazolidone |
67458 |
January 1, 1990 |
|
Furmecyclox |
60568050 |
January 1, 1990 |
|
Fusarin C |
79748815 |
July 1, 1995 |
|
|
|
|
|
Ganciclovir sodium |
82410320 |
August 26, 1997 |
|
Gasoline engine exhaust
(condensates/extracts) |
--- |
October 1, 1990 |
Gemfibrozil
|
25812300
|
December
22, 2000
|
|
Glasswool fibers (airborne
particles of respirable size) |
--- |
July 1, 1990 |
|
Glu-P-1
(2-Amino-6-methyldipyrido[1,2- a:3',2'-d]imidazole) |
67730114 |
January 1, 1990 |
|
Glu-P-2
(2-Aminodipyrido[1,2-a:3',2'-d]imidazole) |
67730103 |
January 1, 1990 |
|
Glycidaldehyde |
765344 |
January 1, 1988 |
|
Glycidol |
556525 |
July 1, 1990 |
|
Griseofulvin |
126078 |
January 1, 1990 |
|
Gyromitrin (Acetaldehyde
methylformylhydrazone) |
16568028 |
January 1, 1988 |
|
|
|
|
|
HC Blue 1 |
2784943 |
July 1, 1989 |
|
Heptachlor |
76448 |
July 1, 1988 |
|
Heptachlor epoxide |
1024573 |
July 1, 1988 |
|
Hexachlorobenzene |
118741 |
October 1, 1987 |
|
Hexachlorocyclohexane
(technical grade) |
--- |
October 1, 1987 |
|
Hexachlorodibenzodioxin |
34465468 |
April 1, 1988 |
|
Hexachloroethane |
67721 |
July 1, 1990 |
|
Hexamethylphosphoramide |
680319 |
January 1, 1988 |
|
Hydrazine |
302012 |
January 1, 1988 |
|
Hydrazine sulfate |
10034932 |
January 1, 1988 |
|
Hydrazobenzene
(1,2-Diphenylhydrazine) |
122667 |
January 1, 1988 |
|
|
|
|
|
Indeno [1,2,3-cd]pyrene |
193395 |
January 1, 1988 |
Indium
phosphide
|
22398807
|
February
27, 2001
|
|
IQ
(2-Amino-3-methylimidazo[4,5-f]quinoline) |
76180966 |
April 1, 1990 |
|
Iprodione |
36734197 |
May 1, 1996 |
|
Iron dextran complex |
9004664 |
January 1, 1988 |
|
Isobutyl nitrite |
542563 |
May 1, 1996 |
|
Isoprene |
78795 |
May 1, 1996 |
|
Isosafrole |
120581 |
October 1, 1989 |
Isoxaflutole
|
141112290
|
December
22, 2000
|
|
|
|
|
|
Lactofen |
77501634 |
January 1, 1989 |
|
Lasiocarpine |
303344 |
April 1, 1988 |
|
Lead acetate |
301042 |
January 1, 1988 |
|
Lead and lead compounds |
--- |
October 1, 1992 |
|
Lead phosphate |
7446277 |
April 1, 1988 |
|
Lead subacetate |
1335326 |
October 1, 1989 |
|
Lindane and other
hexachlorocyclohexane isomers |
--- |
October 1, 1989 |
Lynestrenol
|
52766
|
February
27, 2001
|
|
|
|
|
|
Mancozeb |
8018017 |
January 1, 1990 |
|
Maneb |
12427382 |
January 1, 1990 |
|
Me-A-alpha-C
(2-Amino-3-methyl-9H-pyrido[2,3-b]indole) |
68006837 |
January 1, 1990 |
|
Medroxyprogesterone
acetate |
71589 |
January 1, 1990 |
|
MeIQ(2-Amino-3,4-dimethylimidazo[4,5-f]quinoline) |
77094112 |
October 1, 1994 |
|
MeIQx(2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline) |
77500040 |
October 1, 1994 |
|
Melphalan |
148823 |
February 27, 1987 |
|
Merphalan |
531760 |
April 1, 1988 |
|
Mestranol |
72333 |
April 1, 1988 |
|
Metham sodium |
137428 |
November 6, 1998 |
|
8-Methoxypsoralen with
ultraviolet A therapy |
298817 |
February 27, 1987 |
|
5-Methoxypsoralen with
ultraviolet A therapy |
484208 |
October 1, 1988 |
|
2-Methylaziridine
(Propyleneimine) |
75558 |
January 1, 1988 |
|
Methylazoxymethanol |
590965 |
April 1, 1988 |
|
Methylazoxymethanol
acetate |
592621 |
April 1, 1988 |
|
Methyl carbamate |
598550 |
May 15, 1998 |
|
3-Methylcholanthrene |
56495 |
January 1, 1990 |
|
5-Methylchrysene |
3697243 |
April 1, 1988 |
|
4,4'-Methylene
bis(2-chloroaniline) |
101144 |
July 1, 1987 |
|
4,4'-Methylene
bis(N,N-dimethyl)benzenamine |
101611 |
October 1, 1989 |
|
4,4'-Methylene
bis(2-methylaniline) |
838880 |
April 1, 1988 |
|
4,4'-Methylenedianiline |
101779 |
January 1, 1988 |
|
4,4'-Methylenedianiline
dihydrochloride |
13552448 |
January 1, 1988 |
|
Methyleugenol |
93152 |
November 16, 2001 |
|
Methylhydrazine and its
salts |
--- |
July 1, 1992 |
|
Methyl iodide |
74884 |
April 1, 1988 |
|
Methylmercury compounds |
--- |
May 1, 1996 |
|
Methyl methanesulfonate |
66273 |
April 1, 1988 |
|
2-Methyl-1-nitroanthraquinone
(of uncertain purity) |
129157 |
April 1, 1988 |
|
N-Methyl-N'-nitro-N-nitrosoguanidine |
70257 |
April 1, 1988 |
|
N-Methylolacrylamide |
924425 |
July 1, 1990 |
|
Methylthiouracil |
56042 |
October 1, 1989 |
|
Metiram |
9006422 |
January 1, 1990 |
|
Metronidazole |
443481 |
January 1, 1988 |
|
Michler's ketone |
90948 |
January 1, 1988 |
|
Mirex |
2385855 |
January 1, 1988 |
|
Mitomycin C |
50077 |
April 1, 1988 |
|
Monocrotaline |
315220 |
April 1, 1988 |
|
5-(Morpholinomethyl)-3-[(5-nitro-furfurylidene)-
amino] -2-oxazolidinone |
139913 |
April 1, 1988 |
|
Mustard Gas |
505602 |
February 27, 1987 |
MX
(3-chloro-4-dichloromethyl-5-hydroxy-2(5H)-furanone)
|
77439760
|
December
22, 2000
|
|
|
|
|
|
Nafenopin |
3771195 |
April 1, 1988 |
|
Nalidixic acid |
389082 |
May 15, 1998 |
|
Naphthalene |
91203 |
April 19, 2002 |
|
1-Naphthylamine |
134327 |
October 1, 1989 |
|
2-Naphthylamine |
91598 |
February 27, 1987 |
|
Nickel and certain nickel
compounds |
--- |
October 1, 1989 |
|
Nickel carbonyl |
13463393 |
October 1, 1987 |
|
Nickel refinery dust from
the pyrometallurgical process |
--- |
October 1, 1987 |
|
Nickel subsulfide |
12035722 |
October 1, 1987 |
|
Niridazole |
61574 |
April 1, 1988 |
|
Nitrilotriacetic acid |
139139 |
January 1, 1988 |
|
Nitrilotriacetic acid,
trisodium salt monohydrate |
18662538 |
April 1, 1989 |
|
5-Nitroacenaphthene |
602879 |
April 1, 1988 |
|
5-Nitro-o-anisidine |
99592 |
October 1, 1989 |
|
o-Nitroanisole |
91236 |
October 1, 1992 |
|
Nitrobenzene |
98953 |
August 26, 1997 |
|
4-Nitrobiphenyl |
92933 |
April 1, 1988 |
|
6-Nitrochrysene |
7496028 |
October 1, 1990 |
|
Nitrofen (technical grade) |
1836755 |
January 1, 1988 |
|
2-Nitrofluorene |
607578 |
October 1, 1990 |
|
Nitrofurazone |
59870 |
January 1, 1990 |
|
1-[(5-Nitrofurfurylidene)-amino]-2-imidazolidinone |
555840 |
April 1, 1988 |
|
N-[4-(5-Nitro-2-furyl)-2-thiazolyl]acetamide |
531828 |
April 1, 1988 |
|
Nitrogen mustard
(Mechlorethamine) |
51752 |
January 1, 1988 |
|
Nitrogen mustard
hydrochloride (Mechlorethamine hydrochloride) |
55867 |
April 1, 1988 |
|
Nitrogen mustard N-oxide |
126852 |
April 1, 1988 |
|
Nitrogen mustard N-oxide
hydrochloride |
302705 |
April 1, 1988 |
|
Nitromethane |
75525 |
May 1, 1997 |
|
2-Nitropropane |
79469 |
January 1, 1988 |
|
1-Nitropyrene |
5522430 |
October 1, 1990 |
|
4-Nitropyrene |
57835924 |
October 1, 1990 |
|
N-Nitrosodi-n-butylamine |
924163 |
October 1, 1987 |
|
N-Nitrosodiethanolamine |
1116547 |
January 1, 1988 |
|
N-Nitrosodiethylamine |
55185 |
October 1, 1987 |
|
N-Nitrosodimethylamine |
62759 |
October 1, 1987 |
|
p-Nitrosodiphenylamine |
156105 |
January 1, 1988 |
|
N-Nitrosodiphenylamine |
86306 |
April 1, 1988 |
|
N-Nitrosodi-n-propylamine |
621647 |
January 1, 1988 |
|
N-Nitroso-N-ethylurea |
759739 |
October 1, 1987 |
|
3-(N-Nitrosomethylamino)propionitrile |
60153493 |
April 1, 1990 |
|
4-(N-Nitrosomethylamino)-1-(3-pyridyl)1-butanone |
64091914 |
April 1, 1990 |
|
N-Nitrosomethylethylamine |
10595956 |
October 1, 1989 |
|
N-Nitroso-N-methylurea |
684935 |
October 1, 1987 |
|
N-Nitroso-N-methylurethane |
615532 |
April 1, 1988 |
|
N-Nitrosomethylvinylamine |
4549400 |
January 1, 1988 |
|
N-Nitrosomorpholine |
59892 |
January 1, 1988 |
|
N-Nitrosonornicotine |
16543558 |
January 1, 1988 |
|
N-Nitrosopiperidine |
100754 |
January 1, 1988 |
|
N-Nitrosopyrrolidine |
930552 |
October 1, 1987 |
|
N-Nitrososarcosine |
13256229 |
January 1, 1988 |
|
o-Nitrotoluene |
88722 |
May 15, 1998 |
|
Norethisterone
(Norethindrone) |
68224 |
October 1, 1989 |
|
Norethynodrel |
68235 |
February 27, 2001 |
|
|
|
|
|
Ochratoxin A |
303479 |
July 1, 1990 |
|
Oil Orange SS |
2646175 |
April 1, 1988 |
|
Oral contraceptives,
combined |
--- |
October 1, 1989 |
|
Oral contraceptives,
sequential |
--- |
October 1, 1989 |
|
Oxadiazon |
19666309 |
July 1, 1991 |
|
Oxazepam |
604751 |
October 1, 1994 |
|
Oxymetholone |
434071 |
January 1, 1988 |
Oxythioquinox
|
2439012
|
August 20, 1999
|
|
|
|
|
|
Palygorskite
fibers (> 5mm in length) |
12174117 |
December
28, 1999 |
|
Panfuran S |
794934 |
January 1, 1988 |
|
Pentachlorophenol |
87865 |
January 1, 1990 |
|
Phenacetin |
62442 |
October 1, 1989 |
|
Phenazopyridine |
94780 |
January 1, 1988 |
|
Phenazopyridine
hydrochloride |
136403 |
January 1, 1988 |
|
Phenesterin |
3546109 |
July 1, 1989 |
|
Phenobarbital |
50066 |
January 1, 1990 |
|
Phenolphthalein |
77098 |
May 15, 1998 |
|
Phenoxybenzamine |
59961 |
April 1, 1988 |
|
Phenoxybenzamine
hydrochloride |
63923 |
April 1, 1988 |
|
o-Phenylenediamine and its
salts |
95545 |
May 15, 1998 |
|
Phenyl glycidyl ether |
122601 |
October 1, 1990 |
|
Phenylhydrazine and its
salts |
--- |
July 1, 1992 |
|
o-Phenylphenate, sodium |
132274 |
January 1, 1990 |
|
o-Phenylphenol |
90437 |
August 4, 2000 |
|
PhiP(2-Amino-1-methyl-6-phenylimidazol[4,5-b]pyridine) |
105650235 |
October 1, 1994 |
|
Polybrominated biphenyls |
--- |
January 1, 1988 |
|
Polychlorinated biphenyls |
--- |
October 1, 1989 |
|
Polychlorinated biphenyls
(containing 60 or more percent chlorine by molecular weight) |
--- |
January 1, 1988 |
|
Polychlorinated
dibenzo-p-dioxins |
--- |
October 1, 1992 |
|
Polychlorinated
dibenzofurans |
--- |
October 1, 1992 |
|
Polygeenan |
53973981 |
January 1, 1988 |
|
Ponceau MX |
3761533 |
April 1, 1988 |
|
Ponceau 3R |
3564098 |
April 1, 1988 |
|
Potassium bromate |
7758012 |
January 1, 1990 |
|
Primidone |
125337 |
August 20, 1999 |
|
Procarbazine |
671169 |
January 1, 1988 |
|
Procarbazine hydrochloride |
366701 |
January 1, 1988 |
|
Procymidone |
32809168 |
October 1, 1994 |
|
Progesterone |
57830 |
January 1, 1988 |
|
Pronamide |
23950585 |
May 1, 1996 |
Propachlor
|
1918167
|
February
27, 2001
|
|
1,3-Propane sultone |
1120714 |
January 1, 1988 |
|
Propargite |
2312358 |
October 1, 1994 |
|
beta-Propiolactone |
57578 |
January 1, 1988 |
|
Propylene oxide |
75569 |
October 1, 1988 |
|
Propylthiouracil |
51525 |
January 1, 1988 |
|
Pyridine |
110861 |
May 17, 2002 |
|
|
|
|
|
Quinoline and its strong
acid salts |
--- |
October 24, 1997 |
|
|
|
|
|
Radionuclides |
--- |
July 1, 1989 |
|
Reserpine |
50555 |
October 1, 1989 |
|
Residual (heavy) fuel oils |
--- |
October 1, 1990 |
|
|
|
|
|
|
|
|
|
|
|
|
|
Safrole |
94597 |
January 1, 1988 |
|
Salicylazosulfapyridine |
599791 |
May 15, 1998 |
|
Selenium sulfide |
7446346 |
October 1, 1989 |
|
Shale-oils |
68308349 |
April 1, 1990 |
|
Silica, crystalline
(airborne particles of respirable size) |
--- |
October 1, 1988 |
|
Soots, tars, and mineral
oils (untreated and mildly treated oils and used engine oils) |
--- |
February 27, 1987 |
|
Spironolactone |
52017 |
May 1, 1997 |
|
Stanozolol |
10418038 |
May 1, 1997 |
|
Sterigmatocystin |
10048132 |
April 1, 1988 |
|
Streptozotocin
(streptozocin) |
18883664 |
January 1, 1988 |
|
Styrene oxide |
96093 |
October 1, 1988 |
|
Sulfallate |
95067 |
January 1, 1988 |
|
|
|
|
|
Talc containing
asbestiform fibers |
--- |
April 1, 1990 |
|
Tamoxifen and its salts |
10540291 |
September 1, 1996 |
|
Terrazole |
2593159 |
October 1, 1994 |
|
Testosterone and its
esters |
58220 |
April 1, 1988 |
|
2,3,7,8-Tetrachlorodibenzo-para-dioxin
(TCDD) |
1746016 |
January 1, 1988 |
|
1,1,2,2-Tetrachloroethane |
79345 |
July 1, 1990 |
|
Tetrachloroethylene
(Perchloroethylene) |
127184 |
April 1, 1988 |
|
p-a,a,a-Tetrachlorotoluene |
5216251 |
January 1, 1990 |
|
Tetrafluoroethylene |
116143 |
May 1, 1997 |
|
Tetranitromethane |
509148 |
July 1, 1990 |
|
Thioacetamide |
62555 |
January 1, 1988 |
|
4,4'-Thiodianiline |
139651 |
April 1, 1988 |
|
Thiodicarb |
59669260 |
August 20, 1999 |
|
Thiourea |
62566 |
January 1, 1988 |
|
Thorium dioxide |
1314201 |
February 27, 1987 |
|
Tobacco, oral use of
smokeless products |
--- |
April 1, 1988 |
|
Tobacco smoke |
--- |
April 1, 1988 |
|
Toluene diisocyanate |
26471625 |
October 1, 1989 |
|
ortho-Toluidine |
95534 |
January 1, 1988 |
|
ortho-Toluidine
hydrochloride |
636215 |
January 1, 1988 |
|
|
|
|
|
Toxaphene (Polychlorinated
camphenes) |
8001352 |
January 1, 1988 |
|
Treosulfan |
299752 |
February 27, 1987 |
|
Trichlormethine
(Trimustine hydrochloride) |
817094 |
January 1, 1992 |
|
Trichloroethylene |
79016 |
April 1, 1988 |
|
2,4,6-Trichlorophenol |
88062 |
January 1, 1988 |
|
1,2,3-Trichloropropane |
96184 |
October 1,1992 |
|
Trimethyl phosphate |
512561 |
May 1, 1996 |
|
2,4,5-Trimethylaniline and
its strong acid salts |
--- |
October 24, 1997 |
|
Triphenyltin hydroxide |
76879 |
July 1, 1992 |
|
|
|
|
|
Tris(aziridinyl)-para-benzoquinone
(Triaziquone) |
68768 |
October 1, 1989 |
|
Tris(1-aziridinyl)phosphine
sulfide (Thiotepa) |
52244 |
January 1, 1988 |
|
Tris(2-chloroethyl)
phosphate |
115968 |
April 1, 1992 |
|
Tris(2,3-dibromopropyl)phosphate |
126727 |
January 1, 1988 |
|
Trp-P-1 (Tryptophan-P-1) |
62450060 |
April 1, 1988 |
|
Trp-P-2 (Tryptophan-P-2) |
62450071 |
April 1, 1988 |
|
Trypan blue (commercial
grade) |
72571 |
October 1, 1989 |
|
|
|
|
|
Unleaded gasoline (wholly
vaporized) |
--- |
April 1, 1988 |
|
Uracil mustard |
66751 |
April 1, 1988 |
|
Urethane (Ethyl carbamate) |
51796 |
January 1, 1988 |
|
|
|
|
|
Vinclozolin |
50471448 |
August 20, 1999 |
|
Vinyl bromide |
593602 |
October 1, 1988 |
|
Vinyl chloride |
75014 |
February 27, 1987 |
|
4-Vinylcyclohexene |
100403 |
May 1, 1996 |
|
4-Vinyl-1-cyclohexene
diepoxide (Vinyl cyclohexenedioxide) |
106876 |
July 1, 1990 |
|
Vinyl fluoride |
75025 |
May 1, 1997 |
|
Vinyl trichloride
(1,1,2-Trichloroethane) |
79005 |
October 1, 1990 |
|
|
|
|
|
2,6-Xylidine
(2,6-Dimethylaniline) |
87627 |
January 1, 1991 |
|
|
|
|
Zileuton
|
111406872
|
December
22, 2000
|
|
|
|
|
CHEMICALS KNOWN TO THE STATE TO CAUSE REPRODUCTIVE
TOXICITY
|
Chemical |
Type of Reproductive
Toxicity |
CAS No. |
Date Listed |
|
|
|
|
|
|
Acetazolamide |
developmental |
59665 |
August 20, 1999 |
|
Acetohydroxamic acid |
developmental |
546883 |
April 1, 1990 |
|
Actinomycin D |
developmental |
50760 |
October 1, 1992 |
|
All-trans retinoic acid |
developmental |
302794 |
January 1, 1989 |
|
Alprazolam |
developmental |
28981977 |
July 1, 1990 |
|
Altretamine |
developmental, male |
645056 |
August 20, 1999 |
Amantadine
hydrochloride
|
developmental
|
665667
|
February
27, 2001
|
|
Amikacin sulfate |
developmental |
39831555 |
July 1, 1990 |
|
Aminoglutethimide |
developmental |
125848 |
July 1, 1990 |
|
Aminoglycosides |
developmental |
--- |
October 1, 1992 |
|
Aminopterin |
developmental, female |
54626 |
July 1, 1987 |
|
Amiodarone hydrochloride |
developmental, female,
male |
19774824 |
August 26, 1997 |
|
Amitraz |
developmental |
33089611 |
March 30, 1999 |
|
Amoxapine |
developmental |
14028445 |
May 15, 1998 |
|
Anabolic steroids |
female, male |
--- |
April 1, 1990 |
|
Angiotensin converting enzyme
(ACE) inhibitors |
developmental |
--- |
October 1, 1992 |
|
|
|
|
|
|
Anisindione |
developmental |
117373 |
October 1, 1992 |
|
Arsenic (inorganic oxides)
|
developmental |
--- |
May 1, 1997 |
|
Aspirin (NOTE: It is especially important not to use aspirin during the last three months of pregnancy, unless specifically directed to do so by a physician because it may cause problems in the unborn child or complications during delivery) |
developmental, female |
50782 |
July 1, 1990 |
|
Atenolol |
developmental |
29122687 |
August 26, 1997 |
|
Auranofin |
developmental |
34031328 |
January 29, 1999 |
|
Azathioprine |
developmental |
446866 |
September 1, 1996 |
|
|
|
|
|
|
Barbiturates |
developmental |
--- |
October 1, 1992 |
|
Beclomethasone
dipropionate |
developmental |
5534098 |
May 15, 1998 |
|
Benomyl |
developmental, male |
17804352 |
July 1, 1991 |
|
Benzene |
developmental, male |
71432 |
December 26, 1997 |
|
Benzodiazepines |
developmental |
--- |
October 1, 1992 |
|
Benzphetamine
hydrochloride |
developmental |
5411223 |
April 1, 1990 |
|
Bischloroethyl nitrosourea
(BCNU) (Carmustine) |
developmental |
154938 |
July 1, 1990 |
|
Bromacil lithium salt |
developmental |
53404196 |
May 18, 1999 |
|
|
male |
|
January 17, 2003 |
|
Bromoxynil |
developmental |
1689845 |
October 1, 1990 |
|
Bromoxynil octanoate |
developmental |
1689992 |
May 18, 1999 |
|
Butabarbital sodium |
developmental |
143817 |
October 1, 1992 |
|
1,4-Butanediol
dimethane-sulfonate (Busulfan) |
developmental |
55981 |
January 1, 1989 |
|
|
|
|
|
|
Cadmium |
developmental, male |
--- |
May 1, 1997 |
|
Carbamazepine |
developmental |
298464 |
January 29, 1999 |
|
Carbon disulfide |
developmental, female,
male |
75150 |
July 1, 1989 |
|
Carbon monoxide |
developmental |
630080 |
July 1, 1989 |
|
Carboplatin |
developmental |
41575944 |
July 1, 1990 |
|
Chenodiol |
developmental |
474259 |
April 1, 1990 |
|
Chinomethionat
(Oxythioquinox)
|
developmental |
2439012 |
November
6, 1998 |
|
Chlorambucil |
developmental |
305033 |
January 1, 1989 |
|
Chlorcyclizine
hydrochloride |
developmental |
1620219 |
July 1, 1987 |
|
Chlordecone (Kepone) |
developmental |
143500 |
January 1, 1989 |
|
Chlordiazepoxide |
developmental |
58253 |
January 1, 1992 |
|
Chlordiazepoxide hydrochloride
|
developmental |
438415 |
January 1, 1992 |
|
1-(2-Chloroethyl)-3-cyclohexyl-1-
nitrosourea (CCNU) (Lomustine) |
developmental |
13010474 |
July 1, 1990 |
|
Chlorsulfuron |
developmental, female,
male |
64902723 |
May 14, 1999 |
|
Cidofovir |
developmental, female,
male |
113852372 |
January 29, 1999 |
|
Cladribine |
developmental |
4291638 |
September 1, 1996 |
|
Clarithromycin |
developmental |
81103119 |
May 1, 1997 |
|
Clobetasol propionate |
developmental, female |
25122467 |
May 15, 1998 |
|
Clomiphene citrate |
developmental |