STATE OF CALIFORNIA

ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF ENVIRONMENTAL HEALTH HAZARD ASSESSMENT

SAFE DRINKING WATER AND TOXIC ENFORCEMENT ACT OF 1986

CHEMICALS KNOWN TO THE STATE TO CAUSE CANCER OR REPRODUCTIVE TOXICITY

JANUARY 17, 2003

The Safe Drinking Water and Toxic Enforcement Act of 1986 requires that the Governor revise and republish at least once per year the list of chemicals known to the State to cause cancer or reproductive toxicity. The identification number indicated in the following list is the Chemical Abstracts Service (CAS) Registry Number. No CAS number is given when several substances are presented as a single listing. The date refers to the initial appearance of the chemical on the list. For easy reference, chemicals which are shown underlined are newly added. Chemicals which are shown with a strikeout were placed on the list with the date noted, and have subsequently been removed.

CHEMICALS KNOWN TO THE STATE TO CAUSE CANCER

Chemical CAS Number Date

A-alpha-C (2-Amino-9H-pyrido[2,3-b]indole) 26148685 January 1, 1990

Acetaldehyde 75070 April 1, 1988

Acetamide 60355 January 1, 1990

Acetochlor 34256821 January 1, 1989

2-Acetylaminofluorene 53963 July 1, 1987

Acifluorfen 62476599 January 1, 1990

Acrylamide 79061 January 1, 1990

Acrylonitrile 107131 July 1, 1987

Actinomycin D 50760 October 1, 1989

Adriamycin (Doxorubicin hydrochloride) 23214928 July 1, 1987

AF-2;[2-(2-furyl)-3-(5-nitro-2-furyl)]acrylamide 3688537 July 1, 1987

Aflatoxins --- January 1, 1988

Alachlor 15972608 January 1, 1989

Alcoholic beverages, when associated with alcohol abuse --- July 1, 1988

Aldrin 309002 July 1, 1988

Allyl chloride Delisted October 29, 1999 107051 January 1, 1990

2-Aminoanthraquinone 117793 October 1, 1989

p-Aminoazobenzene 60093 January 1, 1990

ortho-Aminoazotoluene 97563 July 1, 1987

4-Aminobiphenyl (4-aminodiphenyl) 92671 February 27, 1987

1-Amino-2,4-dibromoanthraquinone 81492 August 26, 1997

3-Amino-9-ethylcarbazole hydrochloride 6109973 July 1, 1989

2-Aminofluorene 153786 January 29, 1999

1-Amino-2-methylanthraquinone 82280 October 1, 1989

2-Amino-5-(5-nitro-2-furyl)-1,3,4-thiadiazole 712685 July 1, 1987

4-Amino-2-nitrophenol 119346 January 29, 1999

Amitrole 61825 July 1, 1987

Analgesic mixtures containing phenacetin --- February 27, 1987

Aniline 62533 January 1, 1990

Aniline hydrochloride 142041 May 15, 1998

ortho-Anisidine 90040 July 1, 1987

ortho-Anisidine hydrochloride 134292 July 1, 1987

Antimony oxide (Antimony trioxide) 1309644 October 1, 1990

Aramite 140578 July 1, 1987

Arsenic (inorganic arsenic compounds) --- February 27, 1987

Asbestos 1332214 February 27, 1987

Auramine 492808 July 1, 1987

Azacitidine 320672 January 1, 1992

Azaserine 115026 July 1, 1987

Azathioprine 446866 February 27, 1987

Azobenzene 103333 January 1, 1990

Benz[a]anthracene 56553 July 1, 1987

Benzene 71432 February 27, 1987

Benzidine [and its salts] 92875 February 27, 1987

Benzidine-based dyes --- October 1, 1992

Benzo[b]fluoranthene 205992 July 1, 1987

Benzo[j]fluoranthene 205823 July 1, 1987

Benzo[k]fluoranthene 207089 July 1, 1987

Benzofuran 271896 October 1, 1990

Benzo[a]pyrene 50328 July 1, 1987

Benzotrichloride 98077 July 1, 1987

Benzyl chloride 100447 January 1, 1990

Benzyl violet 4B 1694093 July 1, 1987

Beryllium and beryllium compounds --- October 1, 1987

Betel quid with tobacco --- January 1, 1990

2,2-Bis(bromomethyl)-1,3-propanediol 3296900 May 1, 1996

Bis(2-chloroethyl)ether 111444 April 1, 1988

N,N-Bis(2-chloroethyl)-2-naphthylamine (Chlornapazine) 494031 February 27, 1987

Bischloroethyl nitrosourea (BCNU) (Carmustine) 154938 July 1, 1987

Bis(chloromethyl)ether 542881 February 27, 1987

Bis(2-chloro-1-methylethyl)ether, technical grade --- October 29, 1999

Bitumens, extracts of steam-refined and air refined --- January 1, 1990

Bracken fern --- January 1, 1990

Bromate 15541454 May 31, 2002

Bromodichloromethane 75274 January 1, 1990

Bromoethane 74964 December 22, 2000

Bromoform 75252 April 1, 1991

1,3-Butadiene 106990 April 1, 1988

1,4-Butanediol dimethanesulfonate (Busulfan) 55981 February 27, 1987

Butylated hydroxyanisole 25013165 January 1, 1990

beta-Butyrolactone 3068880 July 1, 1987

Cacodylic acid 75605 May 1, 1996

Cadmium and cadmium compounds --- October 1, 1987

Caffeic acid 331395 October 1, 1994

Captafol 2425061 October 1, 1988

Captan 133062 January 1, 1990

Carbazole 86748 May 1, 1996

Carbon tetrachloride 56235 October 1, 1987

Carbon-black extracts --- January 1, 1990

N-Carboxymethyl-N-nitrosourea 60391926 January 25, 2002

Ceramic fibers (airborne particles of respirable size) --- July 1, 1990

Certain combined chemotherapy for lymphomas --- February 27, 1987

Chlorambucil 305033 February 27, 1987

Chloramphenicol 56757 October 1, 1989

Chlordane 57749 July 1, 1988

Chlordecone (Kepone) 143500 January 1, 1988

Chlordimeform 6164983 January 1, 1989

Chlorendic acid 115286 July 1, 1989

Chlorinated paraffins (Average chain length, C12; 108171262 July 1, 1989

approximately 60 percent chlorine by weight)

p-Chloroaniline 106478 October 1, 1994

p-Chloroaniline hydrochloride 20265967 May 15, 1998

Chlorodibromomethane Delisted October 29, 1999 124481 January 1, 1990

Chloroethane (Ethyl chloride) 75003 July 1, 1990

1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) 13010474 January 1, 1988

(Lomustine)

1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1- 13909096 October 1, 1988

nitrosourea (Methyl-CCNU)

Chloroform 67663 October 1, 1987

Chloromethyl methyl ether (technical grade) 107302 February 27, 1987

3-Chloro-2-methylpropene 563473 July 1, 1989

1-Chloro-4-nitrobenzene 100005 October 29, 1999

4-Chloro-ortho-phenylenediamine 95830 January 1, 1988

p-Chloro-o-toluidine 95692 January 1, 1990

p-Chloro-o-toluidine, strong acid salts of --- May 15, 1998

5-Chloro-o-toluidine and its strong acid salts --- October 24, 1997

Chloroprene 126998 June 2, 2000

Chlorothalonil 1897456 January 1, 1989

Chlorotrianisene 569573 September 1, 1996

Chlorozotocin 54749905 January 1, 1992

Chromium (hexavalent compounds) --- February 27, 1987

Chrysene 218019 January 1, 1990

C.I. Acid Red 114 6459945 July 1, 1992

C.I. Basic Red 9 monohydrochloride 569619 July 1, 1989

C.I. Direct Blue 15 2429745 August 26, 1997

C.I. Direct Blue 218 28407376 August 26, 1997

C.I. Solvent Yellow 14 842079 May 15, 1998

Ciclosporin (Cyclosporin A; Cyclosporine) 59865133 January 1, 1992

79217600

Cidofovir 113852372 January 29, 1999

Cinnamyl anthranilate 87296 July 1, 1989

Cisplatin 15663271 October 1, 1988

Citrus Red No. 2 6358538 October 1, 1989

Clofibrate 637070 September 1, 1996

Cobalt metal powder 7440484 July 1, 1992

Cobalt [II] oxide 1307966 July 1, 1992

Cobalt sulfate heptahydrate 10026241 June 2, 2000

Coke oven emissions --- February 27, 1987

Conjugated estrogens --- February 27, 1987

Creosotes --- October 1, 1988

para-Cresidine 120718 January 1, 1988

Cupferron 135206 January 1, 1988

Cycasin 14901087 January 1, 1988

Cyclophosphamide (anhydrous) 50180 February 27, 1987

Cyclophosphamide (hydrated) 6055192 February 27, 1987

Cytembena 21739913 May 15, 1998

D&C Orange No. 17 3468631 July 1, 1990

D&C Red No. 8 2092560 October 1, 1990

D&C Red No. 9 5160021 July 1, 1990

D&C Red No. 19 81889 July 1, 1990

Dacarbazine 4342034 January 1, 1988

Daminozide 1596845 January 1, 1990

Dantron (Chrysazin; 1,8-Dihydroxyanthraquinone) 117102 January 1, 1992

Daunomycin 20830813 January 1, 1988

DDD (Dichlorodiphenyldichloroethane) 72548 January 1, 1989

DDE (Dichlorodiphenyldichloroethylene) 72559 January 1, 1989

DDT (Dichlorodiphenyltrichloroethane) 50293 October 1, 1987

DDVP (Dichlorvos) 62737 January 1, 1989

N,N'-Diacetylbenzidine 613354 October 1, 1989

2,4-Diaminoanisole 615054 October 1, 1990

2,4-Diaminoanisole sulfate 39156417 January 1, 1988

4,4'-Diaminodiphenyl ether (4,4'-Oxydianiline) 101804 January 1, 1988

2,4-Diaminotoluene 95807 January 1, 1988

Diaminotoluene (mixed) --- January 1, 1990

Dibenz[a,h]acridine 226368 January 1, 1988

Dibenz[a,j]acridine 224420 January 1, 1988

Dibenz[a,h]anthracene 53703 January 1, 1988

7H-Dibenzo[c,g]carbazole 194592 January 1, 1988

Dibenzo[a,e]pyrene 192654 January 1, 1988

Dibenzo[a,h]pyrene 189640 January 1, 1988

Dibenzo[a,i]pyrene 189559 January 1, 1988

Dibenzo[a,l]pyrene 191300 January 1, 1988

1,2-Dibromo-3-chloropropane (DBCP) 96128 July 1, 1987

2,3-Dibromo-1-propanol 96139 October 1, 1994

Dichloroacetic acid 79436 May 1, 1996

p-Dichlorobenzene 106467 January 1, 1989

3,3'-Dichlorobenzidine 91941 October 1, 1987

3,3'-Dichlorobenzidine dihydrochloride 612839 May 15, 1998

1,4-Dichloro-2-butene 764410 January 1, 1990

3,3'-Dichloro-4,4'-diaminodiphenyl ether 28434868 January 1, 1988

1,1-Dichloroethane 75343 January 1, 1990

Dichloromethane (Methylene chloride) 75092 April 1, 1988

1,2-Dichloropropane 78875 January 1, 1990

1,3-Dichloropropene 542756 January 1, 1989

Dieldrin 60571 July 1, 1988

Dienestrol 84173 January 1, 1990

Diepoxybutane 1464535 January 1, 1988

Diesel engine exhaust --- October 1, 1990

Di(2-ethylhexyl)phthalate 117817 January 1, 1988

1,2-Diethylhydrazine 1615801 January 1, 1988

Diethyl sulfate 64675 January 1, 1988

Diethylstilbestrol (DES) 56531 February 27, 1987

Diglycidyl resorcinol ether (DGRE) 101906 July 1, 1989

Dihydrosafrole 94586 January 1, 1988

Diisopropyl sulfate 2973106 April 1, 1993

3,3'-Dimethoxybenzidine (ortho-Dianisidine) 119904 January 1, 1988

3,3'-Dimethoxybenzidine dihydrochloride 20325400 October 1, 1990

(ortho-Dianisidine dihydrochloride)

Dimethyl sulfate 77781 January 1, 1988

4-Dimethylaminoazobenzene 60117 January 1, 1988

trans-2-[(Dimethylamino)methylimino]-5-[2-(5-nitro-2- 55738540 January 1, 1988

furyl)vinyl]-1,3,4-oxadiazole

7,12-Dimethylbenz(a)anthracene 57976 January 1, 1990

3,3'-Dimethylbenzidine (ortho-Tolidine) 119937 January 1, 1988

3,3'-Dimethylbenzidine dihydrochloride 612828 April 1, 1992

Dimethylcarbamoyl chloride 79447 January 1, 1988

1,1-Dimethylhydrazine (UDMH) 57147 October 1, 1989

1,2-Dimethylhydrazine 540738 January 1, 1988

Dimethylvinylchloride 513371 July 1, 1989

3,7-Dinitrofluoranthene 105735715 August 26, 1997

3,9-Dinitrofluoranthene 22506532 August 26, 1997

1,6-Dinitropyrene 42397648 October 1, 1990

1,8-Dinitropyrene 42397659 October 1, 1990

Dinitrotoluene mixture, 2,4-/2,6- --- May 1, 1996

2,4-Dinitrotoluene 121142 July 1, 1988

2,6-Dinitrotoluene 606202 July 1, 1995

Di-n-propyl isocinchomeronate (MGK Repellent 326) 136458 May 1, 1996

1,4-Dioxane 123911 January 1, 1988

Diphenylhydantoin (Phenytoin) 57410 January 1, 1988

Diphenylhydantoin (Phenytoin), sodium salt 630933 January 1, 1988

Direct Black 38 (technical grade) 1937377 January 1, 1988

Direct Blue 6 (technical grade) 2602462 January 1, 1988

Direct Brown 95 (technical grade) 16071866 October 1, 1988

Disperse Blue 1 2475458 October 1, 1990

Diuron 330541 May 31, 2002

Epichlorohydrin 106898 October 1, 1987

Erionite 12510428 October 1, 1988

Estradiol 17B 50282 January 1, 1988

Estragole 140670 October 29, 1999

Estrone 53167 January 1, 1988

Estropipate 7280377 August 26, 1997

Ethinylestradiol 57636 January 1, 1988

Ethoprop 13194484 February 27, 2001

Ethyl acrylate 140885 July 1, 1989

Ethyl methanesulfonate 62500 January 1, 1988

Ethyl-4,4'-dichlorobenzilate 510156 January 1, 1990

Ethylene dibromide 106934 July 1, 1987

Ethylene dichloride (1,2-Dichloroethane) 107062 October 1, 1987

Ethylene oxide 75218 July 1, 1987

Ethylene thiourea 96457 January 1, 1988

Ethyleneimine 151564 January 1, 1988

Fenoxycarb 72490018 June 2, 2000

Folpet 133073 January 1, 1989

Formaldehyde (gas) 50000 January 1, 1988

2-(2-Formylhydrazino)-4-(5-nitro-2-furyl)thiazole 3570750 January 1, 1988

Furan 110009 October 1, 1993

Furazolidone 67458 January 1, 1990

Furmecyclox 60568050 January 1, 1990

Fusarin C 79748815 July 1, 1995

Ganciclovir sodium 82410320 August 26, 1997

Gasoline engine exhaust (condensates/extracts) --- October 1, 1990

Gemfibrozil 25812300 December 22, 2000

Glasswool fibers (airborne particles of respirable size) --- July 1, 1990

Glu-P-1 (2-Amino-6-methyldipyrido[1,2- 67730114 January 1, 1990

a:3',2'-d]imidazole)

Glu-P-2 (2-Aminodipyrido[1,2-a:3',2'-d]imidazole) 67730103 January 1, 1990

Glycidaldehyde 765344 January 1, 1988

Glycidol 556525 July 1, 1990

Griseofulvin 126078 January 1, 1990

Gyromitrin (Acetaldehyde methylformylhydrazone) 16568028 January 1, 1988

HC Blue 1 2784943 July 1, 1989

Heptachlor 76448 July 1, 1988

Heptachlor epoxide 1024573 July 1, 1988

Hexachlorobenzene 118741 October 1, 1987

Hexachlorocyclohexane (technical grade) --- October 1, 1987

Hexachlorodibenzodioxin 34465468 April 1, 1988

Hexachloroethane 67721 July 1, 1990

Hexamethylphosphoramide 680319 January 1, 1988

Hydrazine 302012 January 1, 1988

Hydrazine sulfate 10034932 January 1, 1988

Hydrazobenzene (1,2-Diphenylhydrazine) 122667 January 1, 1988

Indeno [1,2,3-cd]pyrene 193395 January 1, 1988

Indium phosphide 22398807 February 27, 2001

IQ (2-Amino-3-methylimidazo[4,5-f]quinoline) 76180966 April 1, 1990

Iprodione 36734197 May 1, 1996

Iron dextran complex 9004664 January 1, 1988

Isobutyl nitrite 542563 May 1, 1996

Isoprene 78795 May 1, 1996

Isosafrole 120581 October 1, 1989

Isoxaflutole 141112290 December 22, 2000

Lactofen 77501634 January 1, 1989

Lasiocarpine 303344 April 1, 1988

Lead acetate 301042 January 1, 1988

Lead and lead compounds --- October 1, 1992

Lead phosphate 7446277 April 1, 1988

Lead subacetate 1335326 October 1, 1989

Lindane and other hexachlorocyclohexane isomers --- October 1, 1989

Lynestrenol 52766 February 27, 2001

Mancozeb 8018017 January 1, 1990

Maneb 12427382 January 1, 1990

Me-A-alpha-C (2-Amino-3-methyl-9H-pyrido[2,3-b]indole) 68006837 January 1, 1990

Medroxyprogesterone acetate 71589 January 1, 1990

MeIQ(2-Amino-3,4-dimethylimidazo[4,5-f]quinoline) 77094112 October 1, 1994

MeIQx(2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline) 77500040 October 1, 1994

Melphalan 148823 February 27, 1987

Merphalan 531760 April 1, 1988

Mestranol 72333 April 1, 1988

Metham sodium 137428 November 6, 1998

8-Methoxypsoralen with ultraviolet A therapy 298817 February 27, 1987

5-Methoxypsoralen with ultraviolet A therapy 484208 October 1, 1988

2-Methylaziridine (Propyleneimine) 75558 January 1, 1988

Methylazoxymethanol 590965 April 1, 1988

Methylazoxymethanol acetate 592621 April 1, 1988

Methyl carbamate 598550 May 15, 1998

3-Methylcholanthrene 56495 January 1, 1990

5-Methylchrysene 3697243 April 1, 1988

4,4'-Methylene bis(2-chloroaniline) 101144 July 1, 1987

4,4'-Methylene bis(N,N-dimethyl)benzenamine 101611 October 1, 1989

4,4'-Methylene bis(2-methylaniline) 838880 April 1, 1988

4,4'-Methylenedianiline 101779 January 1, 1988

4,4'-Methylenedianiline dihydrochloride 13552448 January 1, 1988

Methyleugenol 93152 November 16, 2001

Methylhydrazine and its salts --- July 1, 1992

Methyl iodide 74884 April 1, 1988

Methylmercury compounds --- May 1, 1996

Methyl methanesulfonate 66273 April 1, 1988

2-Methyl-1-nitroanthraquinone (of uncertain purity) 129157 April 1, 1988

N-Methyl-N'-nitro-N-nitrosoguanidine 70257 April 1, 1988

N-Methylolacrylamide 924425 July 1, 1990

Methylthiouracil 56042 October 1, 1989

Metiram 9006422 January 1, 1990

Metronidazole 443481 January 1, 1988

Michler's ketone 90948 January 1, 1988

Mirex 2385855 January 1, 1988

Mitomycin C 50077 April 1, 1988

Monocrotaline 315220 April 1, 1988

5-(Morpholinomethyl)-3-[(5-nitro-furfurylidene)- 139913 April 1, 1988

amino]-2-oxazolidinone

Mustard Gas 505602 February 27, 1987

MX (3-chloro-4-dichloromethyl-5-hydroxy-2(5H)-furanone) 77439760 December 22, 2000

Nafenopin 3771195 April 1, 1988

Nalidixic acid 389082 May 15, 1998

Naphthalene 91203 April 19, 2002

1-Naphthylamine 134327 October 1, 1989

2-Naphthylamine 91598 February 27, 1987

Nickel and certain nickel compounds --- October 1, 1989

Nickel carbonyl 13463393 October 1, 1987

Nickel refinery dust from the pyrometallurgical process --- October 1, 1987

Nickel subsulfide 12035722 October 1, 1987

Niridazole 61574 April 1, 1988

Nitrilotriacetic acid 139139 January 1, 1988

Nitrilotriacetic acid, trisodium salt monohydrate 18662538 April 1, 1989

5-Nitroacenaphthene 602879 April 1, 1988

5-Nitro-o-anisidine 99592 October 1, 1989

o-Nitroanisole 91236 October 1, 1992

Nitrobenzene 98953 August 26, 1997

4-Nitrobiphenyl 92933 April 1, 1988

6-Nitrochrysene 7496028 October 1, 1990

Nitrofen (technical grade) 1836755 January 1, 1988

2-Nitrofluorene 607578 October 1, 1990

Nitrofurazone 59870 January 1, 1990

1-[(5-Nitrofurfurylidene)-amino]-2-imidazolidinone 555840 April 1, 1988

N-[4-(5-Nitro-2-furyl)-2-thiazolyl]acetamide 531828 April 1, 1988

Nitrogen mustard (Mechlorethamine) 51752 January 1, 1988

Nitrogen mustard hydrochloride (Mechlorethamine 55867 April 1, 1988

hydrochloride)

Nitrogen mustard N-oxide 126852 April 1, 1988

Nitrogen mustard N-oxide hydrochloride 302705 April 1, 1988

Nitromethane 75525 May 1, 1997

2-Nitropropane 79469 January 1, 1988

1-Nitropyrene 5522430 October 1, 1990

4-Nitropyrene 57835924 October 1, 1990

N-Nitrosodi-n-butylamine 924163 October 1, 1987

N-Nitrosodiethanolamine 1116547 January 1, 1988

N-Nitrosodiethylamine 55185 October 1, 1987

N-Nitrosodimethylamine 62759 October 1, 1987

p-Nitrosodiphenylamine 156105 January 1, 1988

N-Nitrosodiphenylamine 86306 April 1, 1988

N-Nitrosodi-n-propylamine 621647 January 1, 1988

N-Nitroso-N-ethylurea 759739 October 1, 1987

3-(N-Nitrosomethylamino)propionitrile 60153493 April 1, 1990

4-(N-Nitrosomethylamino)-1-(3-pyridyl)1-butanone 64091914 April 1, 1990

N-Nitrosomethylethylamine 10595956 October 1, 1989

N-Nitroso-N-methylurea 684935 October 1, 1987

N-Nitroso-N-methylurethane 615532 April 1, 1988

N-Nitrosomethylvinylamine 4549400 January 1, 1988

N-Nitrosomorpholine 59892 January 1, 1988

N-Nitrosonornicotine 16543558 January 1, 1988

N-Nitrosopiperidine 100754 January 1, 1988

N-Nitrosopyrrolidine 930552 October 1, 1987

N-Nitrososarcosine 13256229 January 1, 1988

o-Nitrotoluene 88722 May 15, 1998

Norethisterone (Norethindrone) 68224 October 1, 1989

Norethynodrel 68235 February 27, 2001

Ochratoxin A 303479 July 1, 1990

Oil Orange SS 2646175 April 1, 1988

Oral contraceptives, combined --- October 1, 1989

Oral contraceptives, sequential --- October 1, 1989

Oxadiazon 19666309 July 1, 1991

Oxazepam 604751 October 1, 1994

Oxymetholone 434071 January 1, 1988

Oxythioquinox 2439012 August 20, 1999

Palygorskite fibers (> 5mm in length) 12174117 December 28, 1999

Panfuran S 794934 January 1, 1988

Pentachlorophenol 87865 January 1, 1990

Phenacetin 62442 October 1, 1989

Phenazopyridine 94780 January 1, 1988

Phenazopyridine hydrochloride 136403 January 1, 1988

Phenesterin 3546109 July 1, 1989

Phenobarbital 50066 January 1, 1990

Phenolphthalein 77098 May 15, 1998

Phenoxybenzamine 59961 April 1, 1988

Phenoxybenzamine hydrochloride 63923 April 1, 1988

o-Phenylenediamine and its salts 95545 May 15, 1998

Phenyl glycidyl ether 122601 October 1, 1990

Phenylhydrazine and its salts --- July 1, 1992

o-Phenylphenate, sodium 132274 January 1, 1990

o-Phenylphenol 90437 August 4, 2000

PhiP(2-Amino-1-methyl-6-phenylimidazol[4,5-b]pyridine) 105650235 October 1, 1994

Polybrominated biphenyls --- January 1, 1988

Polychlorinated biphenyls --- October 1, 1989

Polychlorinated biphenyls (containing 60 or more --- January 1, 1988

percent chlorine by molecular weight)

Polychlorinated dibenzo-p-dioxins --- October 1, 1992

Polychlorinated dibenzofurans --- October 1, 1992

Polygeenan 53973981 January 1, 1988

Ponceau MX 3761533 April 1, 1988

Ponceau 3R 3564098 April 1, 1988

Potassium bromate 7758012 January 1, 1990

Primidone 125337 August 20, 1999

Procarbazine 671169 January 1, 1988

Procarbazine hydrochloride 366701 January 1, 1988

Procymidone 32809168 October 1, 1994

Progesterone 57830 January 1, 1988

Pronamide 23950585 May 1, 1996

Propachlor 1918167 February 27, 2001

1,3-Propane sultone 1120714 January 1, 1988

Propargite 2312358 October 1, 1994

beta-Propiolactone 57578 January 1, 1988

Propylene oxide 75569 October 1, 1988

Propylthiouracil 51525 January 1, 1988

Pyridine 110861 May 17, 2002

Quinoline and its strong acid salts --- October 24, 1997

Radionuclides --- July 1, 1989

Reserpine 50555 October 1, 1989

Residual (heavy) fuel oils --- October 1, 1990

Saccharin Delisted April 6, 2001 81072 October 1, 1989

Saccharin, sodium Delisted January 17, 2003 128449 January 1, 1988

Safrole 94597 January 1, 1988

Salicylazosulfapyridine 599791 May 15, 1998

Selenium sulfide 7446346 October 1, 1989

Shale-oils 68308349 April 1, 1990

Silica, crystalline (airborne particles of respirable size) --- October 1, 1988

Soots, tars, and mineral oils (untreated and mildly --- February 27, 1987

treated oils and used engine oils)

Spironolactone 52017 May 1, 1997

Stanozolol 10418038 May 1, 1997

Sterigmatocystin 10048132 April 1, 1988

Streptozotocin (streptozocin) 18883664 January 1, 1988

Styrene oxide 96093 October 1, 1988

Sulfallate 95067 January 1, 1988

Talc containing asbestiform fibers --- April 1, 1990

Tamoxifen and its salts 10540291 September 1, 1996

Terrazole 2593159 October 1, 1994

Testosterone and its esters 58220 April 1, 1988

2,3,7,8-Tetrachlorodibenzo-para-dioxin (TCDD) 1746016 January 1, 1988

1,1,2,2-Tetrachloroethane 79345 July 1, 1990

Tetrachloroethylene (Perchloroethylene) 127184 April 1, 1988

p-a,a,a-Tetrachlorotoluene 5216251 January 1, 1990

Tetrafluoroethylene 116143 May 1, 1997

Tetranitromethane 509148 July 1, 1990

Thioacetamide 62555 January 1, 1988

4,4'-Thiodianiline 139651 April 1, 1988

Thiodicarb 59669260 August 20, 1999

Thiourea 62566 January 1, 1988

Thorium dioxide 1314201 February 27, 1987

Tobacco, oral use of smokeless products --- April 1, 1988

Tobacco smoke --- April 1, 1988

Toluene diisocyanate 26471625 October 1, 1989

ortho-Toluidine 95534 January 1, 1988

ortho-Toluidine hydrochloride 636215 January 1, 1988

para-Toluidine Delisted October 29, 1999 106490 January 1, 1990

Toxaphene (Polychlorinated camphenes) 8001352 January 1, 1988

Treosulfan 299752 February 27, 1987

Trichlormethine (Trimustine hydrochloride) 817094 January 1, 1992

Trichloroethylene 79016 April 1, 1988

2,4,6-Trichlorophenol 88062 January 1, 1988

1,2,3-Trichloropropane 96184 October 1,1992

Trimethyl phosphate 512561 May 1, 1996

2,4,5-Trimethylaniline and its strong acid salts --- October 24, 1997

Triphenyltin hydroxide 76879 July 1, 1992

Trichloroethylene 79016 April 1, 1988

Tris(aziridinyl)-para-benzoquinone (Triaziquone) 68768 October 1, 1989

Tris(1-aziridinyl)phosphine sulfide (Thiotepa) 52244 January 1, 1988

Tris(2-chloroethyl) phosphate 115968 April 1, 1992

Tris(2,3-dibromopropyl)phosphate 126727 January 1, 1988

Trp-P-1 (Tryptophan-P-1) 62450060 April 1, 1988

Trp-P-2 (Tryptophan-P-2) 62450071 April 1, 1988

Trypan blue (commercial grade) 72571 October 1, 1989

Unleaded gasoline (wholly vaporized) --- April 1, 1988

Uracil mustard 66751 April 1, 1988

Urethane (Ethyl carbamate) 51796 January 1, 1988

Vinclozolin 50471448 August 20, 1999

Vinyl bromide 593602 October 1, 1988

Vinyl chloride 75014 February 27, 1987

4-Vinylcyclohexene 100403 May 1, 1996

4-Vinyl-1-cyclohexene diepoxide (Vinyl cyclohexenedioxide) 106876 July 1, 1990

Vinyl fluoride 75025 May 1, 1997

Vinyl trichloride (1,1,2-Trichloroethane) 79005 October 1, 1990

2,6-Xylidine (2,6-Dimethylaniline) 87627 January 1, 1991

Zileuton 111406872 December 22, 2000

Zineb Delisted October 29, 1999 12122677 January 1, 1990

CHEMICALS KNOWN TO THE STATE TO CAUSE REPRODUCTIVE TOXICITY

Chemical Type of Reproductive Toxicity CAS No. Date Listed

Acetazolamide developmental 59665 August 20, 1999

Acetohydroxamic acid developmental 546883 April 1, 1990

Actinomycin D developmental 50760 October 1, 1992

All-trans retinoic acid developmental 302794 January 1, 1989

Alprazolam developmental 28981977 July 1, 1990

Altretamine developmental, male 645056 August 20, 1999

Amantadine hydrochloride developmental 665667 February 27, 2001

Amikacin sulfate developmental 39831555 July 1, 1990

Aminoglutethimide developmental 125848 July 1, 1990

Aminoglycosides developmental --- October 1, 1992

Aminopterin developmental, female 54626 July 1, 1987

Amiodarone hydrochloride developmental, female, male 19774824 August 26, 1997

Amitraz developmental 33089611 March 30, 1999

Amoxapine developmental 14028445 May 15, 1998

Anabolic steroids female, male --- April 1, 1990

Angiotensin converting enzyme developmental --- October 1, 1992

(ACE) inhibitors

Anisindione developmental 117373 October 1, 1992

Arsenic (inorganic oxides) developmental --- May 1, 1997

Aspirin (NOTE: It is especially developmental, female 50782 July 1, 1990

important not to use aspirin during the last three months of pregnancy, unless specifically directed to do so by a physician because it may cause problems in the unborn child or complications during delivery.)

Atenolol developmental 29122687 August 26, 1997

Auranofin developmental 34031328 January 29, 1999

Azathioprine developmental 446866 September 1, 1996

Barbiturates developmental --- October 1, 1992

Beclomethasone dipropionate developmental 5534098 May 15, 1998

Benomyl developmental, male 17804352 July 1, 1991

Benzene developmental, male 71432 December 26, 1997

Benzodiazepines developmental --- October 1, 1992

Benzphetamine hydrochloride developmental 5411223 April 1, 1990

Bischloroethyl nitrosourea developmental 154938 July 1, 1990
(BCNU) (Carmustine)

Bromacil lithium salt developmental 53404196 May 18, 1999

male January 17, 2003

Bromoxynil developmental 1689845 October 1, 1990

Bromoxynil octanoate developmental 1689992 May 18, 1999

Butabarbital sodium developmental 143817 October 1, 1992

1,4-Butanediol dimethane- developmental 55981 January 1, 1989

sulfonate (Busulfan)

Cadmium developmental, male --- May 1, 1997

Carbamazepine developmental 298464 January 29, 1999

Carbon disulfide developmental, female, male 75150 July 1, 1989

Carbon monoxide developmental 630080 July 1, 1989

Carboplatin developmental 41575944 July 1, 1990

Chenodiol developmental 474259 April 1, 1990

Chinomethionat (Oxythioquinox) developmental 2439012 November 6, 1998

Chlorambucil developmental 305033 January 1, 1989

Chlorcyclizine hydrochloride developmental 1620219 July 1, 1987

Chlordecone (Kepone) developmental 143500 January 1, 1989

Chlordiazepoxide developmental 58253 January 1, 1992

Chlordiazepoxide hydrochloride developmental 438415 January 1, 1992

1-(2-Chloroethyl)-3-cyclohexyl-1- developmental 13010474 July 1, 1990

nitrosourea (CCNU) (Lomustine)

Chlorsulfuron developmental, female, male 64902723 May 14, 1999

Cidofovir developmental, female, male 113852372 January 29, 1999

Cladribine developmental 4291638 September 1, 1996

Clarithromycin developmental 81103119 May 1, 1997

Clobetasol propionate developmental, female 25122467 May 15, 1998

Clomiphene citrate developmental 50419 April 1, 1990

Clorazepate dipotassium developmental 57109907 October 1, 1992

Cocaine developmental, female 50362 July 1, 1989

Codeine phosphate developmental 52288 May 15, 1998

Colchicine developmental, male 64868 October 1, 1992

Conjugated estrogens developmental --- April 1, 1990

Cyanazine developmental 21725462 April 1, 1990

Cycloate developmental 1134232 March 19, 1999

Cyclohexanol male 108930 November 6, 1998

Delisted January 25, 2002

Cycloheximide developmental 66819 January 1, 1989

Cyclophosphamide (anhydrous) developmental, female, male 50180 January 1, 1989

Cyclophosphamide (hydrated) developmental, female, male 6055192 January 1, 1989

Cyhexatin developmental 13121705 January 1, 1989

Cytarabine developmental 147944 January 1, 1989

Dacarbazine developmental 4342034 January 29, 1999

Danazol developmental 17230885 April 1, 1990

Daunorubicin hydrochloride developmental 23541506 July 1, 1990

2,4-D butyric acid developmental, male 94826 June 18, 1999

o,p'-DDT developmental, female, male 789026 May 15, 1998

p,p'-DDT developmental, female, male 50293 May 15, 1998

2,4-DP (dichloroprop) developmental 120365 April 27, 1999

Delisted January 25, 2002

Demeclocycline hydrochloride developmental 64733 January 1, 1992

(internal use)

Diazepam developmental 439145 January 1, 1992

Diazoxide developmental 364987 February 27, 2001

1,2-Dibromo-3-chloropropane male 96128 February 27, 1987

(DBCP)

Dichlorophene developmental 97234 April 27, 1999

Dichlorphenamide developmental 120978 February 27, 2001

Diclofop methyl developmental 51338273 March 5, 1999

Dicumarol developmental 66762 October 1, 1992

Diethylstilbestrol (DES) developmental 56531 July 1, 1987

Diflunisal developmental, female 22494424 January 29, 1999

Dihydroergotamine mesylate developmental 6190392 May 1, 1997

Diltiazem hydrochloride developmental 33286225 February 27, 2001

m-Dinitrobenzene male 99650 July 1, 1990

o-Dinitrobenzene male 528290 July 1, 1990

p-Dinitrobenzene male 100254 July 1, 1990

2,4-Dinitrotoluene male 121142 August 20, 1999

2,6-Dinitrotoluene male 606202 August 20, 1999

Dinitrotoluene (technical grade) female, male --- August 20, 1999

Dinocap developmental 39300453 April 1, 1990

Dinoseb developmental, male 88857 January 1, 1989

Diphenylhydantoin (Phenytoin) developmental 57410 July 1, 1987

Disodium cyanodithio- developmental 138932 March 30, 1999

imidocarbonate

Doxorubicin hydrochloride developmental, male 23214928 January 29, 1999

Doxycycline (internal use) developmental 564250 July 1, 1990

Doxycycline calcium (internal use) developmental 94088854 January 1, 1992

Doxycycline hyclate (internal use) developmental 24390145 October 1, 1991

Doxycycline monohydrate developmental 17086281 October 1, 1991

(internal use)

Endrin developmental 72208 May 15, 1998

Epichlorohydrin male 106898 September 1, 1996

Ergotamine tartrate developmental 379793 April 1, 1990

Estropipate developmental 7280377 August 26, 1997

Ethionamide developmental 536334 August 26, 1997

Ethyl alcohol in alcoholic developmental --- October 1, 1987

beverages

Ethyl dipropylthiocarbamate developmental 759944 April 27, 1999

Ethylene dibromide developmental, male 106934 May 15, 1998

Ethylene glycol monoethyl ether developmental, male 110805 January 1, 1989

Ethylene glycol monomethyl ether developmental, male 109864 January 1, 1989

Ethylene glycol monoethyl ether developmental, male 111159 January 1, 1993

acetate

Ethylene glycol monomethyl ether developmental, male 110496 January 1, 1993

acetate

Ethylene oxide female 75218 February 27, 1987

Ethylene thiourea developmental 96457 January 1, 1993

Etodolac developmental, female 41340254 August 20, 1999

Etoposide developmental 33419420 July 1, 1990

Etretinate developmental 54350480 July 1, 1987

Fenoxaprop ethyl developmental 66441234 March 26, 1999

Filgrastim developmental 121181531 February 27, 2001

Fluazifop butyl developmental 69806504 November 6, 1998

Flunisolide developmental, female 3385033 May 15, 1998

Fluorouracil developmental 51218 January 1, 1989

Fluoxymesterone developmental 76437 April 1, 1990

Flurazepam hydrochloride developmental 1172185 October 1, 1992

Flurbiprofen developmental, female 5104494 August 20, 1999

Flutamide developmental 13311847 July 1, 1990

Fluticasone propionate developmental 80474142 May 15, 1998

Fluvalinate developmental 69409945 November 6, 1998

Ganciclovir sodium developmental, male 82410320 August 26, 1997

Gemfibrozil female, male 25812300 August 20, 1999

Goserelin acetate developmental, female, male 65807025 August 26, 1997

Halazepam developmental 23092173 July 1, 1990

Halobetasol propionate developmental 66852548 August 20, 1999

Haloperidol developmental, female 52868 January 29, 1999

Halothane developmental 151677 September 1, 1996

Heptachlor developmental 76448 August 20, 1999

Hexachlorobenzene developmental 118741 January 1, 1989

Hexamethylphosphoramide male 680319 October 1, 1994

Histrelin acetate developmental --- May 15, 1998

Hydramethylnon developmental, male 67485294 March 5, 1999

Hydroxyurea developmental 127071 May 1, 1997

Idarubicin hydrochloride developmental, male 57852570 August 20, 1999

Ifosfamide developmental 3778732 July 1, 1990

Iodine-131 developmental 10043660 January 1, 1989

Isotretinoin developmental 4759482 July 1, 1987

Lead developmental, female, male --- February 27, 1987

Leuprolide acetate developmental, female, male 74381536 August 26, 1997

Levodopa developmental 59927 January 29, 1999

Levonorgestrel implants female 797637 May 15, 1998

Linuron developmental 330552 March 19, 1999

Lithium carbonate developmental 554132 January 1, 1991

Lithium citrate developmental 919164 January 1, 1991

Lorazepam developmental 846491 July 1, 1990

Lovastatin developmental 75330755 October 1, 1992

Mebendazole developmental 31431397 August 20, 1999

Medroxyprogesterone acetate developmental 71589 April 1, 1990

Megestrol acetate developmental 595335 January 1, 1991

Melphalan developmental 148823 July 1, 1990

Menotropins developmental 9002680 April 1, 1990

Meprobamate developmental 57534 January 1, 1992

Mercaptopurine developmental 6112761 July 1, 1990

Mercury and mercury compounds developmental --- July 1, 1990

Methacycline hydrochloride developmental 3963959 January 1, 1991

Metham sodium developmental 137428 May 15, 1998

Methazole developmental 20354261 December 1, 1999

Methimazole developmental 60560 July 1, 1990

Methotrexate developmental 59052 January 1, 1989

Methotrexate sodium developmental 15475566 April 1, 1990

Methyl bromide developmental 74839 January 1, 1993

as a structural fumigant

Methyl chloride developmental 74873 March 10, 2000

Methyl mercury developmental --- July 1, 1987

N-Methylpyrrolidone developmental 872504 June 15, 2001

Methyltestosterone developmental 58184 April 1, 1990

Metiram developmental 9006422 March 30, 1999

Midazolam hydrochloride developmental 59467968 July 1, 1990

Minocycline hydrochloride developmental 13614987 January 1, 1992

(internal use)

Misoprostol developmental 59122462 April 1, 1990

Mitoxantrone hydrochloride developmental 70476823 July 1, 1990

Myclobutanil developmental, male 88671890 April 16, 1999

Nabam developmental 142596 March 30, 1999

Nafarelin acetate developmental 86220420 April 1, 1990

Neomycin sulfate (internal use) developmental 1405103 October 1, 1992

Netilmicin sulfate developmental 56391572 July 1, 1990

Nickel carbonyl developmental 13463393 September 1, 1996

Nicotine developmental 54115 April 1, 1990

Nifedipine developmental, female, male 21829254 January 29, 1999

Nimodipine developmental 66085594 April 24, 2001

Nitrapyrin developmental 1929824 March 30, 1999

Nitrofurantoin male 67209 April 1, 1991

Nitrogen mustard developmental 51752 January 1, 1989

(Mechlorethamine)

Nitrogen mustard hydrochloride developmental 55867 July 1, 1990

(Mechlorethamine hydrochloride)

Norethisterone (Norethindrone) developmental 68224 April 1, 1990

Norethisterone acetate developmental 51989 October 1, 1991

(Norethindrone acetate)

Norethisterone (Norethindrone) developmental 68224/57636 April 1, 1990

/Ethinyl estradiol

Norethisterone (Norethindrone) developmental 68224/72333 April 1, 1990

/Mestranol

Norgestrel developmental 6533002 April 1, 1990

Oxadiazon developmental 19666309 May 15, 1998

Oxazepam developmental 604751 October 1, 1992

Oxydemeton methyl female, male 301122 November 6, 1998

Oxymetholone developmental 434071 May 1, 1997

Oxytetracycline (internal use) developmental 79572 January 1, 1991

Oxytetracycline hydrochloride developmental 2058460 October 1, 1991

(internal use)

Paclitaxel developmental, female, male 33069624 August 26, 1997

Paramethadione developmental 115673 July 1, 1990

Penicillamine developmental 52675 January 1, 1991

Pentobarbital sodium developmental 57330 July 1, 1990

Pentostatin developmental 53910251 September 1, 1996

Phenacemide developmental 63989 July 1, 1990

Phenprocoumon developmental 435972 October 1, 1992

Pimozide developmental, female 2062784 August 20, 1999

Pipobroman developmental 54911 July 1, 1990

Plicamycin developmental 18378897 April 1, 1990

Polybrominated biphenyls developmental --- October 1, 1994

Polychlorinated biphenyls developmental --- January 1, 1991

Potassium dimethyldithio- developmental 128030 March 30 1999

carbamate

Pravastatin sodium developmental 81131706 March 3, 2000

Prednisolone sodium phosphate developmental 125020 August 20, 1999

Procarbazine hydrochloride developmental 366701 July 1, 1990

Propargite developmental 2312358 June 15, 1999

Propylthiouracil developmental 51525 July 1, 1990

Pyrimethamine developmental 58140 January 29, 1999

Quazepam developmental 36735225 August 26, 1997

Quizalofop-ethyl male 76578148 December 24, 1999

Resmethrin developmental 10453868 November 6, 1998

Retinol/retinyl esters, when in developmental --- July 1, 1989

daily dosages in excess of 10,000 IU, or 3,000 retinol equivalents. (NOTE: Retinol/retinyl esters are required and essential for maintenance of normal reproductive function. The recommended daily level during pregnancy is 8,000 IU.)

Ribavirin developmental 36791045 April 1, 1990

male 36791045 February 27, 2001

Rifampin developmental, female 13292461 February 27, 2001

Secobarbital sodium developmental 309433 October 1, 1992

Sermorelin acetate developmental --- August 20, 1999

Sodium dimethyldithiocarbamate developmental 128041 March 30 1999

Sodium fluoroacetate male 62748 November 6, 1998

Streptomycin sulfate developmental 3810740 January 1, 1991

Streptozocin (streptozotocin) developmental, female, male 18883664 August 20, 1999

Sulfasalazine male 599791 January 29, 1999

Sulindac developmental, female 38194502 January 29, 1999

Tamoxifen citrate developmental 54965241 July 1, 1990

Temazepam developmental 846504 April 1, 1990

Teniposide developmental 29767202 September 1, 1996

Terbacil developmental 5902512 May 18, 1999

Testosterone cypionate developmental 58208 October 1, 1991

Testosterone enanthate developmental 315377 April 1, 1990

2,3,7,8-Tetrachlorodibenzo-para- developmental 1746016 April 1, 1991

dioxin (TCDD)

Tetracycline (internal use) developmental 60548 October 1, 1991

Tetracyclines (internal use) developmental --- October 1, 1992

Tetracycline hydrochloride developmental 64755 January 1, 1991

(internal use)

Thalidomide developmental 50351 July 1, 1987

Thioguanine developmental 154427 July 1, 1990

Thiophanate methyl female, male 23564058 May 18, 1999

Tobacco smoke (primary) developmental, female, male --- April 1, 1988

Tobramycin sulfate developmental 49842071 July 1, 1990

Toluene developmental 108883 January 1, 1991

Triadimefon developmental, female, male 43121433 March 30, 1999

Triazolam developmental 28911015 April 1, 1990

Tributyltin methacrylate developmental 2155706 December 1, 1999

Trientine hydrochloride developmental 38260014 February 27, 2001

Triforine developmental 26644462 June 18, 1999

37273840

Trilostane developmental 13647353 April 1, 1990

Trimethadione developmental 127480 January 1, 1991

Trimetrexate glucuronate developmental 82952645 August 26, 1997

Triphenyltin hydroxide developmental 76879 March 18, 2002

Uracil mustard developmental, female, male 66751 January 1, 1992

Urethane developmental 51796 October 1, 1994

Urofollitropin developmental 26995915 April 1, 1990

Valproate (Valproic acid) developmental 99661 July 1, 1987

Vinblastine sulfate developmental 143679 July 1, 1990

Vinclozolin developmental 50471448 May 15, 1998

Vincristine sulfate developmental 2068782 July 1, 1990

Warfarin developmental 81812 July 1, 1987

Zileuton developmental, female 111406872 December 22, 2000

Date: January 17, 2003