|
The California Environmental Protection Agency’s Office of
Environmental Health Hazard Assessment (OEHHA), as lead agency for
the implementation of the Safe Drinking Water and Toxic Enforcement
Act of 1986 (Proposition 65), has developed a procedure for prioritizing
chemicals for consideration under Proposition 65 by the "State’s
qualified experts". Two committees of the Science Advisory
Board (SAB), known as the Carcinogen Identification Committee, and
the Developmental and Reproductive Toxicant (DART) Identification
Committee, serve as the State’s qualified experts for rendering
an opinion as to whether a chemical is known to the State to cause
cancer, birth defects or other reproductive harm.
The procedure used by OEHHA to identify, prioritize and select
candidate chemicals for evaluation by the SAB Committees is described
in, "Procedure for Prioritizing Candidate Chemicals for Consideration
Under Proposition 65 by the State’s Qualified Experts,"
May 1997 and is available on the Internet at /prop65/policy_procedure/prioproc.html.
In accordance with this procedure, prioritized chemicals with a
final priority of High Carcinogenicity
Concern are assigned to the Candidate List, from which chemicals
will be chosen for the preparation of hazard identification documents,
and subsequent evaluation by the Carcinogen Identification Committee.
All chemicals not assigned a final "high" level of carcinogenicity
concern are assigned to Category II.
In a slight change from previous releases, where draft priorities
of Medium High, Medium, and Low Carcinogenicity Concern were stated
explicitly in the data summaries, here draft priorities are identified
as either "High" Carcinogenicity
Concern, or "Not High"
enough to merit placement on the Candidate List. We are implementing
this change following the recognition that considerable resources
have been expended by both the interested public and the State in
the course of providing and responding to comments not pertinent
to the placement of chemicals on or off the Candidate List. The
main purpose of this phase of the prioritization process is to decide
which chemicals should appear on the Candidate List; many of the
comments received on previous releases focused on refining the priority
of chemicals within Category II. We welcome comments from the public
on this change.
The data summaries are available for download as an Adobe Acrobat
PDF file.
Download the draft data summaries.
With this notice we are announcing the release of draft data summaries
and draft priorities concerning the potential for the chemicals
indicated below to cause cancer. This notice initiates a 60-day
public comment period. These 60 chemicals were selected for prioritization
as described in OEHHA’s Notice to Interested Parties: Results
of the Second Round Pilot Random Selection of the Chemicals Eligible
for Prioritization For Consideration of Carcinogenicity Evaluation,
published in the California Regulatory Notice Register on April
3, 1998. The chemicals and their draft priorities are as follows:
| Name of Chemical |
CAS No.
|
| On Candidate List
due to High Carcinogenicity Concern
|
|
allyl isovalerate
|
2835-39-4
|
|
4-bis(2-hydroxyethyl)amino-2-(5-nitro-2-thienyl)-quinazoline
|
33372-39-3
|
|
bleomycin
|
11056-06-7
|
|
1-butylhydrazine hydrochloride
|
56795-65-4
|
|
carboxymethylnitrosourea
|
60391-92-6
|
|
3-chloromethylpyridine hydrochloride
|
6959-48-4
|
|
chrysoidine
|
532-82-1
|
|
N,N'-diethylthiourea
|
105-55-5
|
|
3,3'-dimethoxybenzidine-4,4'-diisocyanate
|
91-93-0
|
|
dimethyldiazene-1-oxide (methylazoxymethane / azoxymethane)
|
25843-45-2
|
|
estradiol mustard
|
22966-79-6
|
|
N'-ethyl-N-methyl-N-nitrosourea
|
72479-13-1
|
|
N'-ethyl-N-nitrosobutylamine
|
4549-44-4
|
|
4-ethylsulfonylnaphthalene-1-sulfonamide
|
842-00-2
|
|
hexachlorobutadiene
|
87-68-3
|
|
ICRF-159
|
21416-87-5
|
|
isophosphamide
|
3778-73-2
|
|
lovastatin
|
75330-75-5
|
|
N-(2-methoxyethyl)-N-nitrosourea
|
108278-70-2
|
|
3'-methyl-4-dimethylaminoazobenzene
|
55-80-1
|
|
methylphenidate and its hydrochloride (Ritalin)
|
113-45-1
|
|
4-methylquinoline
|
491-35-0
|
|
MX (3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone)
|
77439-76-0
|
|
6-nitrobenzimidazole
|
94-52-0
|
|
N-nitrosomethyl-N-heptylamine
|
16338-99-1
|
|
N-nitroso-N-pentylurea (N-amyl-N-nitrosurea)
|
10589-74-9
|
|
petasitenine
|
60102-37-6
|
|
phenelzine and its acid salts
|
156-51-4
|
|
pivalolactone
|
1955-45-9
|
|
pyrrolizidine alkaloids which are metabolized to dehydroretronecine
or dehydroheliotridine
|
---
|
|
sesamol
|
533-31-3
|
|
styrene
|
100-42-5
|
|
tetrachlorvinphos
|
22248-79-9
|
|
2,4,6-trimethylaniline and its hydrochloride (aminomesitylene)
|
88-05-1
|
| Name of Chemical |
CAS No.
|
Category II
(Not High Carcinogenicity Concern) |
|
2-amino-5-nitrothiazole
|
121-66-4
|
|
11-aminoundecanoic acid
|
2432-99-7
|
|
antipyrine (phenazone)
|
60-80-0
|
|
p-benzoquinone dioxime
|
105-11-3
|
|
C.I. acid blue 9 and its salts
|
2650-18-2
|
|
C.I. acid red 51
|
16423-68-0
|
|
chlorinated paraffins (C23; 43% chlorine)
|
108171-27-3
|
|
4-chloro-4'-aminodiphenyl ether
|
101-79-1
|
|
4-chloro-m-phenlyenediamine
|
5131-60-2
|
|
dibromomannitol
|
488-41-5
|
|
diclofop-methyl
|
51338-27-3
|
|
diltiazem
|
42399-41-7
|
|
FD&C blue no. 2
|
860-22-0
|
|
malathion
|
121-75-5
|
|
6-methoxy-2-nitronaphtho[1,8-bc]pyran
|
10502-39-9
|
|
mexacarbate
|
315-18-4
|
|
omeprazole
|
73590-58-6
|
|
tocopherol mix (E-mix 80)
|
1406-66-2
|
|
triadimenol
|
55219-65-3
|
|
tribenuron methyl
|
101200-48-0
|
|
trimethylthiourea
|
2489-77-2
|
|
tris(2-ethylhexyl)phosphate (trioctyl phosphate)
|
78-42-2
|
|
troysan polyphase (IPBC)
|
55406-53-6
|
| Inadequate
Data to establish level of concern |
|
1-butanol (n-butanol, n-butyl alcohol)
|
71-36-3
|
|
2-bromo-2-methylpropane (tert-butyl bromide)
|
507-19-7
|
| Postponed |
|
bis(4-chlorophenyl)sulfone (p,p'-dichlorophenylsulfone)
|
80-07-9
|
OEHHA also announces that a public workshop to receive external
scientific peer review and public comments on the draft data summaries
and draft priority assignments for these chemicals will be held
on Friday, April 9, 1999. The workshop will commence at 10:00 a.m.
in Conference Room A, Elihu Harris State Building, 1515 Clay
Street, Oakland California, and will last until all business has
been conducted or until 5:00 p.m.
OEHHA is committed to public participation and external scientific
peer review in its implementation of Proposition 65, and welcomes
public input. The draft data summaries and draft priority assignments
for these chemicals are available from the Proposition 65 Implementation
Office at the address and telephone number indicated below, or from
the Internet at the following address:
Download the draft data summaries.
Written comments may be submitted in triplicate to:
Cynthia Oshita
Office of Environmental Health Hazard Assessment
301 Capitol Mall, 2nd Floor
Sacramento, California 95814
FAX (916) 327-1097
(916) 445-6900
In order to be considered, comments must be postmarked (if sent
by mail) or received at OEHHA (if delivered in person or sent by
FAX) by 5 p.m. Tuesday, April 20, 1999.
You will need the free program Adobe Acrobat Reader to view or
print PDF files 
For questions regarding Proposition 65, please contact the Cynthia
Oshita in the Proposition 65 Implementation Program
For help with this web site please contact the Web
Mistress
|
Conditions of Use/Privacy