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The California Environmental Protection Agency’s Office of Environmental
Health Hazard Assessment (OEHHA), as lead agency for the implementation
of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition
65), has developed a procedure for prioritizing chemicals for consideration
under Proposition 65 by the "State’s qualified experts".
Two committees of the Science Advisory Board (SAB), known as the
Carcinogen Identification Committee (CIC) and the Developmental
and Reproductive Toxicant (DART) Identification Committee, serve
as the State’s qualified experts for rendering an opinion whether
a chemical is known to the State to cause cancer or reproductive
toxicity.
The procedure used by OEHHA to identify, prioritize and select
candidate chemicals for evaluation by the SAB Committees is described
in, "Procedure
for Prioritizing Candidate Chemicals for Consideration Under Proposition
65 by the States Qualified Experts," May 1997, and
is available on the Internet at www.oehha.ca.gov.
On February 18,
1999, OEHHA announced the release of draft priority assignments
and draft data summaries for 59 of 60 chemicals selected for
prioritization with respect to their potential to cause cancer.
The prioritization of one chemical, bis(4-chlorophenyl)sulfone,
has been postponed pending the results of a bioassay expected in
the next one to two years from the National Toxicology Program.
The February 18,
1999, announcement initiated a 60-day public comment period,
which included a public workshop held April 9, 1999. After review
and careful consideration of the comments received, the priority
assignments have been finalized for 54 of the 59 chemicals. OEHHA
staff are evaluating the comments received on the remaining five
chemicals: lovastatin, methylphenidate and its hydrochloride (ritalin),
phenelzine and its acid salts, styrene, and tetrachlorvinphos. The
priority status of these chemicals will remain "draft"
until that process is completed. Some data summaries have been revised
as a result of comments, although the comments did not lead to a
change to the final priority assignments for any of the chemicals.
In accordance with OEHHA’s prioritization procedure, all chemicals
with final priority assignments of "high" carcinogenicity
concern are placed on the final Candidate List (see table below).
All other final prioritized chemicals will be placed in Category
II, which means they will not be the subject of further consideration
at this time. Chemicals are selected from the Candidate List for
the development of draft hazard identification documents and subsequent
consideration for listing by the CIC of OEHHA’s Science Advisory
Board. The final priority assignments for the 54 chemicals are given
below.
Final Priority Assignments
| Name of Chemical |
CAS No. |
| On Candidate List due to HIGH CARCINOGENICITY
CONCERN |
|
Allyl isovalerate
|
2835-39-4 |
|
4-Bis(2-hydroxyethyl)amino-2-(5-nitro-2-thienyl)-quinazoline
|
33372-39-3 |
|
Bleomycin
|
11056-06-7 |
|
1-Butylhydrazine hydrochloride
|
56795-65-4 |
|
Carboxymethylnitrosourea
|
60391-92-6 |
|
3-Chloromethylpyridine hydrochloride
|
6959-48-4 |
|
Chrysoidine
|
532-82-1 |
|
N,N'-Diethylthiourea
|
105-55-5 |
|
3,3'-Dimethoxybenzidine-4,4'-diisocyanate
|
91-93-0 |
|
Dimethyldiazene-1-oxide (methylazoxymethane / azoxymethane)
|
25843-45-2 |
|
N'-Ethyl-N-methyl-N-nitrosourea
|
72479-13-1 |
|
N'-Ethyl-N-nitrosobutylamine
|
4549-44-4 |
|
Estradiol mustard
|
22966-79-6 |
|
4-Ethylsulfonylnaphthalene-1-sulfonamide
|
842-00-2 |
|
Hexachlorobutadiene
|
87-68-3 |
|
ICRF-159
|
21416-87-5 |
|
Isophosphamide
|
3778-73-2 |
|
N-(2-Methoxyethyl)-N-nitrosourea
|
108278-70-2 |
|
3'-Methyl-4-dimethylaminoazobenzene
|
55-80-1 |
|
4-Methylquinoline
|
491-35-0 |
|
MX (3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone)
|
77439-76-0 |
|
6-Nitrobenzimidazole
|
94-52-0 |
|
N-Nitrosomethyl-N-heptylamine
|
16338-99-1 |
|
N-Nitroso-N-pentylurea (N-amyl-N-nitrosurea)
|
10589-74-9 |
|
Petasitenine
|
60102-37-6 |
|
Pivalolactone
|
1955-45-9 |
|
Pyrrolizidine alkaloids which are metabolized to dehydroretronecine
or dehydroheliotridine
|
--- |
|
Sesamol
|
533-31-3 |
|
2,4,6-Trimethylaniline and its hydrochloride (aminomesitylene)
|
88-05-1 |
| Name of Chemical |
CAS No. |
| Category II (Not HIGH CARCINOGENICITY
CONCERN) |
|
2-Amino-5-nitrothiazole
|
121-66-4 |
|
11-Aminoundecanoic acid
|
2432-99-7 |
|
Antipyrine (phenazone)
|
60-80-0 |
|
p-Benzoquinone dioxime
|
105-11-3 |
|
C.I. acid blue 9 and its salts
|
2650-18-2 |
|
C.I. acid red 51
|
16423-68-0 |
|
Chlorinated paraffins (C23; 43% chlorine)
|
108171-27-3 |
|
4-Chloro-4'-aminodiphenyl ether
|
101-79-1 |
|
4-Chloro-m-phenylenediamine
|
5131-60-2 |
|
Dibromomannitol
|
488-41-5 |
|
Diclofop-methyl
|
51338-27-3 |
|
Diltiazem
|
42399-41-7 |
|
FD&C blue no. 2
|
860-22-0 |
|
Malathion
|
121-75-5 |
|
6-Methoxy-2-nitronaphtho[1,8-bc]pyran
|
10502-39-9 |
|
Mexacarbate
|
315-18-4 |
|
Omeprazole
|
73590-58-6 |
|
Tocopherol mix (E-mix 80)
|
1406-66-2 |
|
Triadimenol
|
55219-65-3 |
|
Tribenuron methyl
|
101200-48-0 |
|
Trimethylthiourea
|
2489-77-2 |
|
Tris(2-ethylhexyl)phosphate (trioctyl phosphate)
|
78-42-2 |
|
Troysan polyphase (IPBC)
|
55406-53-6 |
| INADEQUATE DATA to establish level
of concern |
|
1-Butanol (n-butanol, n-butyl alcohol)
|
71-36-3 |
|
2-Bromo-2-methylpropane (tert-butyl bromide)
|
507-19-7 |
Copies of the final data summaries and priority assignments for
these chemicals are available from the Proposition 65 Implementation
Office at the address and telephone number indicated below, or from
the download area below.
Follow this
link to download this Notice in PDF format. (recommended for
printing)
Follow this link to download
a copy of the final data summaries and priority assignments for
the above chemicals in PDF format.
Cynthia Oshita
Office of Environmental Health Hazard Assessment
Post Office Box 4010
Sacramento, CA 95812-4010
Fax (916) 327-1097
(916) 445-6900
You will need the free program Adobe Acrobat Reader to view or
print PDF files 
For questions regarding Proposition 65, please contact the Cynthia
Oshita in the Proposition 65 Implementation Program
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