The Safe Drinking Water and Toxic Enforcement Act
of 1986 (Proposition 65) provides two mechanisms for administratively
listing chemicals which are known to the State to cause cancer
or reproductive toxicity (Health and Safety Code Section 25249.8(b)).
One such mechanism by which a chemical may be listed is if a body
considered to be authoritative by the states qualified experts
has formally identified it as causing cancer or reproductive toxicity.
The following are identified as authoritative bodies for purposes
of Proposition 65 as it pertains to chemicals known to cause reproductive
toxicity: the US Environmental Protection Agency (US EPA), the
International Agency for Research on Cancer (IARC) (for transplacental
carcinogenicity only), the US Food and Drug Administration (FDA),
and the National Institute for Occupational Safety and Health
(NIOSH). The criteria for listing chemicals through the authoritative
bodies mechanism are set forth in Title 22, California Code
of Regulations (22 CCR), Section 12306.
As the lead agency for the implementation of Proposition
65, the Office of Environmental Health Hazard Assessment (OEHHA)
of the California Environmental Protection Agency intends to list
the chemicals identified below as known to the State to cause
reproductive toxicity, pursuant to this administrative mechanism
as provided in Health and Safety Code Section 25249.8(b)
and 22 CCR, Section 12306.
Three of the chemicals in todays notice, nitrapyrin,
triadimefon and triphenyltin hydroxide, were announced in a public
notice published on October 9, 1998 requesting relevant information.
The other 8 chemicals included in todays notice were announced
in a public notice published on October 30, 1998 requesting relevant
information. Public forums were held on November 20, 1998
and December 18, 1998, respectively. Public comments were received
on only one of these chemicals, nitrapyrin. OEHHA has completed
its review of the comments and has determined the chemicals meet
the criteria for listing under 22 CCR, Section 12306.
OEHHA is issuing this notice of intent to list for the chemicals
identified in the table below. A document providing more detail
on the basis for the listing can be obtained from OEHHAs
Proposition 65 Implementation Office at the address and telephone
number indicated below, or from the OEHHA Home Page at: http://www.oehha.ca.gov.
Anyone objecting to the listing of the chemicals identified below
as causing reproductive toxicity on the basis that there is no
substantial evidence that the criteria of sufficiency of evidence
of reproductive toxicity identified in 22 CCR, Section 12306
have been satisfied should provide written comments in triplicate,
along with supporting documentation, by mail or by fax to:
Ms. Cynthia Oshita
Office of Environmental Health Hazard Assessment
301 Capitol Mall, 2nd Floor, Room 205
Sacramento, California 95814
Fax No.: (916) 327-1097
Telephone: (916) 445-6900
Comments may also be hand-delivered to Ms. Oshita
at the Office of Environmental Health Hazard Assessment at the
same address.
In order to be considered, comments must be received
at OEHHA by 5:00 p.m. on Monday, March 1, 1999.
The following chemicals have been determined by
OEHHA to meet the criteria set forth in 22 CCR, Section 12306
for listing as causing reproductive toxicity under the authoritative
bodies mechanism:
|
Chemical
|
CAS No.
|
Toxicological
Endpoint |
Referencea
|
| Amitraz |
33089-61-1
|
developmental
toxicity |
US EPA (1994a,b) |
| Disodium cyanodithio-midocarbonate |
138-93-2
|
developmental
toxicity |
US EPA (1994a,b) |
| Fenbutatin oxide |
13356-08-6
|
developmental
toxicity |
US EPA (1994a,b) |
| Metiram |
9006-42-2
|
developmental
toxicity |
US EPA (1994a,b) |
| Metribuzin |
21087-64-9
|
developmental
toxicity |
US EPA (1994a,b) |
| Nabam |
142-59-6
|
developmental
toxicity |
US EPA (1994a,b) |
| Nitrapyrin |
1929-82-4 |
developmental
toxicity |
US EPA (1994a,b) |
| Potassium dimethyl-dithiocarbamate |
128-03-0
|
developmental
toxicity |
US EPA (1994a,b) |
| Sodium dimethyl-dithiocarbamate |
128-04-1
|
developmental
toxicity |
US EPA (1994a,b) |
| Triadimefon |
43121-43-3 |
developmental
toxicity
male reproductive toxicity
Female reproductive toxicity |
US EPA (1994a,b) |
| Triphenyltin
hydroxide |
76-87-9 |
Developmental
toxicity |
US EPA (1994a,b) |
a Formal identification by US EPA of chemicals
causing reproductive toxicity is provided in US EPA (1994b)
below, while additional information on the basis for such identification
is provided in US EPA (1994a).
References
US Environmental Protection Agency (US EPA, 1994a) Proposed Rule:
Addition of Certain Chemicals; Toxic Chemical Release Reporting;
Community Right to Know. Federal Register (59 FR 1788).
US Environmental Protection Agency (US EPA, 1994b).
Final Rule: Addition of Certain Chemicals; Toxic Chemical Release
Reporting; Community Right to Know. Federal Register (59 FR 61432).
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For questions regarding Proposition 65, please contact the Cynthia
Oshita in the Proposition 65 Implementation Program
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