The California Environmental Protection Agency's Office of Environmental
Health Hazard Assessment (OEHHA) is the lead agency for the implementation
of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition
In public notices which were published on October 4, 1996 in this
register, OEHHA (1) gave notice of a public forum on November 15,
1996, to receive comments on the draft data summaries and levels
of toxicological concern for candidate chemicals to be prioritized
for possible consideration by the Developmental and Reproductive
Toxicant (DART) Identification Committee, and (2) gave notice of
a meeting of the DART Identification Committee on December 4, 1996,
at which the Committee would discuss the same list of draft prioritized
candidate chemicals. Included on the list of draft prioritized candidate
chemicals were carbamazepine and progesterone.
In order to fully explore the potential candidacy of these chemicals
for listing under administrative mechanisms, OEHHA has decided to
postpone action on carbamazepine and progesterone for prioritization
for possible consideration by the DART Identification Committee.
To this end, OEHHA will request clarification from the U.S. Food
and Drug Administration (FDA) concerning (1) the intent of their
required label with regard to communicating a risk of developmental
or reproductive harm, and (2) their findings and conclusions pertaining
to the developmental and reproductive toxicity of these two drugs.
Following receipt of relevant information from the U.S. FDA, OEHHA
will determine the appropriate course of action at that time.
Because of this postponement in consideration of carbamazepine
and progesterone , OEHHA will not be soliciting comment relative
to either of these two chemicals at the November 15, 1996 public
forum, nor will these chemicals be brought before the DART Committee
for consideration at their December 4, 1996 meeting.
Any further action taken on either carbamazepine or progesterone
will be published
in a future notice.
Questions or comments concerning this notice should be directed
Office of Environmental Health Hazard Assessment
Post Office Box 4010
Sacramento, CA 95812-4010
Fax (916) 327-1097
For questions regarding Proposition 65, please contact the Cynthia
Oshita in the Proposition 65 Implementation Program
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